Non-faradaic, capacitively coupled measurement in a nanopore cell array
First Claim
1. A method of identifying a molecule, comprising:
- drawing a molecule to a nanopore by applying a first voltage signal to a pair of electrodes during a first period, wherein the first voltage signal causes a first ionic current through the nanopore that is indicative of a property of a portion of the molecule proximate to the nanopore;
releasing the molecule from the nanopore by applying a second voltage signal to the pair of electrodes during a second period, wherein the second voltage signal causes a second ionic current through the nanopore; and
determining the first period and the second period based at least in part on a net ionic current through the nanopore comprising the first ionic current and the second ionic current.
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Abstract
A method of identifying a molecule is disclosed. A molecule is drawn to a nanopore by applying a first voltage signal to a pair of electrodes during a first period, wherein the first voltage signal causes a first ionic current through the nanopore that is indicative of a property of a portion of the molecule proximate to the nanopore. The molecule is released from the nanopore by applying a second voltage signal to the pair of electrodes during a second period, wherein the second voltage signal causes a second ionic current through the nanopore. The first period and the second period are determined based at least in part on a net ionic current through the nanopore comprising the first ionic current and the second ionic current.
20 Citations
23 Claims
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1. A method of identifying a molecule, comprising:
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drawing a molecule to a nanopore by applying a first voltage signal to a pair of electrodes during a first period, wherein the first voltage signal causes a first ionic current through the nanopore that is indicative of a property of a portion of the molecule proximate to the nanopore; releasing the molecule from the nanopore by applying a second voltage signal to the pair of electrodes during a second period, wherein the second voltage signal causes a second ionic current through the nanopore; and determining the first period and the second period based at least in part on a net ionic current through the nanopore comprising the first ionic current and the second ionic current. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system for identifying a molecule, comprising:
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a voltage control unit controlling a voltage source; a pair of electrodes coupled to the voltage source; and a measurement circuitry; wherein the voltage control unit is configured to; draw a molecule to a nanopore by controlling the voltage source to apply a first voltage signal to the pair of electrodes during a first period, wherein the first voltage signal causes a first ionic current through the nanopore that is indicative of a property of a portion of the molecule proximate to the nanopore; release the molecule from the nanopore by controlling the voltage source to apply a second voltage signal to the pair of electrodes during a second period, wherein the second voltage signal causes a second ionic current through the nanopore; and determine the first period and the second period based at least in part on a net ionic current through the nanopore comprising the first ionic current and the second ionic current; and wherein the measurement circuitry is configured to measure the first ionic current. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification