Imaging through scattering media with high signal to noise ratio and resolution
First Claim
1. A method for sub-acoustic focusing, the method comprising:
- illuminating a sample through a scatterer using a light source and at least one spatial light modulator;
receiving a photoacoustic signal from a transducer;
determining an optimized wavefront from the photoacoustic signal;
modifying a configuration of the spatial light modulator based on the optimized wavefront; and
illuminating the sample through the scatterer using the light source and the spatial light modulator with the modified configuration, wherein the modified configuration produces an optical focus that is smaller than an acoustic focus of the transducer.
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Accused Products
Abstract
Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Some embodiments can increase the optical fluence in an ultrasound transducer focus and/or enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium can serve as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, the object can be scanned in two dimensions and/or a spot can be scanned by re-optimizing the wavefront before post-processing of the data to reconstruct the image. The temporal photoacoustic signal provides information to reconstruct the third-dimensional information.
69 Citations
20 Claims
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1. A method for sub-acoustic focusing, the method comprising:
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illuminating a sample through a scatterer using a light source and at least one spatial light modulator; receiving a photoacoustic signal from a transducer; determining an optimized wavefront from the photoacoustic signal; modifying a configuration of the spatial light modulator based on the optimized wavefront; and illuminating the sample through the scatterer using the light source and the spatial light modulator with the modified configuration, wherein the modified configuration produces an optical focus that is smaller than an acoustic focus of the transducer. - View Dependent Claims (2, 3, 4)
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5. A sub-acoustic resolution imaging system comprising:
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a pulsed light source; an optical system configured to direct light from the light source toward a sample through a scatterer; one or more acoustic transducers configured to record acoustic signals from the sample; and a controller coupled with at least a portion of the optical system and the one or more acoustic transducers, wherein the controller is configured to modify a phase and/or amplitude of the light directed by the optical system through the scatterer using data from the one or more acoustic transducers. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
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13. A method for focusing with sub-acoustic resolution, the method comprising:
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illuminating a sample inside a scatterer with a plurality of optical wavefronts modulated by a spatial light modulator, each of the plurality of optical wavefronts produced modulated by the spatial light modulator using one of a plurality of SLM matrices selected from a population of SLM matrices; receiving a plurality of electric signals from a transducer, wherein each of the plurality of electric signals correspond with a photoacoustic signal received at the transducer for each of the plurality of optical wavefronts such that the transducer receives a plurality of photoacoustic signals; and determining an optimum SLM matrix from the population of SLM matrices based on the plurality of electric signals, wherein the optimum SLM matrix produces an optical focus at or near the sample that is smaller than an acoustic focus of the transducer. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification