Neural activity recording apparatus and method of using same

• US 10,039,460 B2
• Filed: 01/22/2013
• Issued: 08/07/2018
• Est. Priority Date: 01/22/2013
• Status: Active Grant

• Current Assignee: Misleeping Incorporated
• Original Assignee: Misleeping Incorporated
• Inventors: Lang, Todd J.
• Primary Examiner(s): Stoklosa, Joseph
• Assistant Examiner(s): ANTISKAY, BRIAN MICHAEL
• Application Number:
  US13/746,335
• Publication Number:
  US 20140206975A1
• Time in Patent Office: 2,023 Days
• Field of Search: 600372-373, 600382-383, 600386-393, 600544-545
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]

Abstract

An apparatus to enable individuals to record neural activity. The apparatus is designed to be produced at a low cost and may be configured to be disposable or capable of a limited number of uses. The apparatus comprises electrodes, a flexible housing sealably enclosing an energy storage device and an integrated circuit having a memory, a processor, and on-board memory. The electrodes capture the neural activity signals. The integrated circuit samples the neural activity signals and stores corresponding data in memory.

Claims

1. A neural activity recording apparatus comprising:

at least two electrodes configured to establish an electrical path through a patient'"'"'s skin and to acquire a neural activity signal;

an amplifier circuit configured to output an amplified neural activity signal based on the neural activity signal;

an integrated circuit chip (IC) including an instrumentation amplifier to receive and amplify the amplified neural activity signal from the amplifier circuit, a processor, an analog-to-digital converter (ADC), an on-board memory, and a line frequency filter algorithm embedded in the on-board memory, the ADC configured to digitize an amplified neural activity signal from the instrumentation amplifier to produce a sample stream, and the line frequency filter algorithm configured to cancel a substantial portion of a line frequency signal embedded in the sample stream to generate a neural activity data;

a removable memory configured to store the neural activity data;

an energy storage device configured to energize the IC; and

a housing sealingly enclosing the IC, the amplifier circuit, the removable memory and the energy storage device, the housing configured to be unsealed to enable removal of the removable memory,

wherein the neural activity recording apparatus is sized to be attached to and supported by the patient'"'"'s forehead and energized solely by the energy storage device, and

wherein the activity recording apparatus is devoid of an isolation circuit, wherein the IC is directly electrically coupled to the patient'"'"'s skin and to the energy storage device and to the removable memory, without an external connection to power the activity recording apparatus and store the neural activity data, wherein the neural activity data is configured to diagnose sleep/wake patterns during a time period limited by the energy stored in the energy storage device.

2. A neural activity recording apparatus as in claim 1, wherein the IC includes two or more amplifier circuits, and the instrumentation amplifier circuit is configured with the two or more amplifier circuits.

3. A neural activity recording apparatus as in claim 1, wherein the amplifier circuit is positioned near one of the at least two electrodes.

5. A neural activity recording apparatus as in claim 1, wherein the IC further includes an analog-to-digital converter (ADC) configured to generate and provide a common mode feedback signal to the instrumentation amplifier to substantially cancel a common mode signal in the neural activity signal.

6. A neural activity recording apparatus as in claim 1, further comprising an indicator device configured to provide a sleep quality feedback, wherein the indicator device is integrated with the neural activity recording apparatus, and wherein the IC comprises an algorithm configured to determine the sleep quality feedback and to provide an indication thereof with the indicator device.

7. A neural activity recording apparatus as in claim 6, where the indicator device is configured to continuously provide the sleep quality feedback.

8. A neural activity recording apparatus as in claim 6, further comprising a transducer outputting transducer signals, wherein the transducer is integrated with the neural activity recording apparatus, and wherein the IC correlates the transducer signals with the neural activity data to determine the sleep quality feedback.

9. A neural activity recording apparatus as in claim 8, wherein the transducer comprises at least one of a motion transducer and an air flow transducer.

10. A neural activity recording apparatus as in claim 1, further comprising an adhesive material on one side of the housing, the adhesive material configured to adhere the housing to the patient'"'"'s skin, wherein the activity recording apparatus is sized and configured to be entirely supported by the adhesive material adhered to the patient'"'"'s skin.

18. A neural activity recording apparatus as in claim 1, wherein configured to be unsealed comprises configured to be permanently damaged in order to remove the removable memory.

19. A neural activity recording apparatus as in claim 1, further comprising a conductor connecting the IC to the amplifier circuit to provide a common-mode reference signal thereto.

20. A neural activity recording apparatus as in claim 1, wherein the amplifier circuit is positioned in the housing near one of the at least two electrodes and the IC is positioned in the housing near another of the at least two electrodes to reduce noise.

21. A neural activity recording apparatus as in claim 1, wherein the neural activity recording apparatus comprises physiologically relevant signature patterns and is configured to compare the physiologically relevant signature patterns to the neural activity data to identify physiologically relevant data, and wherein the neural activity recording apparatus is configured to only store in the removable memory the physiologically relevant data.

22. A neural activity recording apparatus as in claim 1, wherein the ADC samples the amplified neural activity signal at an integer multiple of a power line frequency, the multiple being greater than 2, and wherein to cancel a substantial portion of a line frequency signal embedded in the sample stream the line frequency filter algorithm is configured to divide the sample stream into a number of sub-streams corresponding to the line frequency multiple, to compute moving averages for each sub-stream, and to subtract the moving averages from each sub-stream to cancel the residual line noise from each sub-stream.

4. A neural activity recording apparatus comprising:

at least two electrodes configured to establish an electrical path through a patient'"'"'s skin and to acquire a neural activity signal;

an amplifier circuit configured to output an amplified neural activity signal based on the neural activity signal;

an integrated circuit chip (IC) including an instrumentation amplifier to receive and amplify the amplified neural activity signal from the amplifier circuit, a processor, an analog-to-digital converter (ADC), an on-board memory, and a line frequency filter algorithm embedded in the on-board memory, the ADC configured to digitize an amplified neural activity signal from the instrumentation amplifier to produce a sample stream, and the line frequency filter algorithm configured to cancel a substantial portion of a line frequency signal embedded in the sample stream to generate a neural activity data;

a removable memory configured to store the neural activity data;

an energy storage device configured to energize the IC; and

a housing sealingly enclosing the IC, the amplifier circuit, the removable memory and the energy storage device, the housing configured to be unsealed to enable removal of the removable memory,

wherein the neural activity recording apparatus is sized to be attached to and supported by the patient'"'"'s forehead and energized solely by the energy storage device, and

wherein the ADC samples the amplified neural activity signal at an integer multiple of a power line frequency, the multiple being greater than 2, and wherein to cancel a substantial portion of a line frequency signal embedded in the sample stream the line frequency filter algorithm is configured to divide the sample stream into a number of sub-streams corresponding to the line frequency multiple, to compute moving averages for each sub-stream, and to subtract the moving averages from each sub-stream to cancel the residual line noise from each sub-stream.

11. A method of recording neural activity with a neural activity recording apparatus, the method comprising:

attaching the neural activity recording apparatus to the patient, the neural activity recording apparatus including at least two electrodes configured to establish an electrical path through a patient'"'"'s skin and to acquire a neural activity signal;

an amplifier circuit configured to output an amplified neural activity signal based on the neural activity signal;

an integrated circuit chip (IC) including a processor, an instrumentation amplifier to receive and amplify the amplified neural activity signal from the amplifier circuit, an analog-to-digital converter (ADC), an on-board memory, and a line frequency filter algorithm embedded in the on-board memory, and the ADC configured to digitize an amplified neural activity signal from the instrumentation amplifier to produce a sample stream;

a removable memory configured to store the neural activity data;

an energy storage device configured to energize the IC; and

a housing sealingly enclosing the IC, the instrumentation amplifier, the removable memory and the energy storage device, the housing configured to be unsealed to enable removal of the removable memory, wherein the neural activity recording apparatus is sized to be attached to and supported by the patient'"'"'s forehead and energized solely by the energy storage device, wherein the activity recording apparatus is devoid of an isolation circuit, wherein the IC is directly electrically coupled to the patient'"'"'s skin and to the energy storage device and to the removable memory, without an external connection to power the activity recording apparatus and store the neural activity data, and wherein the neural activity data is configured to diagnose sleep/wake patterns during a time period limited by the energy stored in the energy storage device;

powering the neural activity recording apparatus with the energy storage device;

amplifying the amplified neural activity signal from the amplifier circuit to generate an amplified neural activity signal by the instrumentation amplifier;

generating a sample stream from the amplified neural activity signal from the instrumentation amplifier circuit;

canceling, with the line frequency filter algorithm, a substantial portion of a line frequency noise signal embedded in the sample stream to generate a neural activity data substantially free of the line frequency noise signal;

storing the neural activity data in a removable memory;

unsealing the housing to enable removal of the removable memory; and

removing the removable memory.

12. A neural activity recording method as in claim 11, wherein unsealing comprises permanently damaging the housing.

13. A neural activity recording method as in claim 11, further comprising discarding the neural activity recording apparatus after a single use.

14. A neural activity recording method as in claim 11, further comprising sampling the amplified neural activity signal at an integer multiple of a power line frequency, the multiple being greater than 0.

15. A neural activity recording method as in claim 14, further comprising dividing the sample stream into at least two sub-streams, computing moving averages for each sub-stream, and computing the neural activity data based on the moving averages of the at least two sub-streams.

16. A neural activity recording method as in claim 11, further comprising providing a common mode feedback signal to the instrumentation amplifier to cancel a common mode signal embedded in the neural activity signal.

17. A neural activity recording method as in claim 16, further comprising an indicator device configured to provide a sleep quality feedback.