Methods for reducing noise in optical biological sensors

• US 10,039,491 B2
• Filed: 06/30/2014
• Issued: 08/07/2018
• Est. Priority Date: 06/30/2014
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Thompson, Jason Donald, Bajaj, Vikram Singh, Acosta, Victor Marcel, Troy, Tamara Lynn
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US14/319,182
• Publication Number:
  US 20150382105A1
• Time in Patent Office: 1,499 Days
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6801 specially adapted to be attached to or worn on the body surface
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick

Abstract

Optical measurement of physiological parameters with wearable devices often includes measuring signals in the presence of significant noise sources. These noise sources include, but are not limited to, noise associated with: variable optical coupling to skin or tissue, variations in tissue optical properties with time due to changes in humidity, temperature, hydration, variations in tissue optical properties between individuals, variable coupling of ambient light sources into detectors, and instrument and detector noise, including electrical noise, radio frequency or magnetic interference, or noise caused by mechanical movement of the detector or its components. The present disclosure includes devices and methods configured to produce representations of the raw data in which noise, broadly defined, is separated from the data of interest. The disclosed devices and methods may include subtracting or calibrating out these noise sources and other spurious fluctuations in wearable devices with optical sensors.

Claims

1. A method comprising:

detecting, by at least one optical detector of a medical diagnostic device, a first optical signal transmitted through a skin surface from within a first portion of a lumen of subsurface vasculature, wherein the first optical signal comprises an unfiltered target signal and a first noise signal;

detecting, by the at least one optical detector of the device, a second optical signal transmitted through the skin surface from within a second portion of the lumen of the subsurface vasculature, wherein the second optical signal comprises a second noise signal, and wherein the first and second noise signals are correlated and wherein a quotient of the unfiltered target signal and the first noise signal comprises an unfiltered signal to noise ratio; and

determining a filtered signal, based at least on the unfiltered target signal, the first noise signal, and the second noise signal, wherein the filtered signal comprises a filtered target signal and a filtered noise signal, wherein a quotient of the filtered target signal and the filtered noise signal comprises a filtered signal to noise ratio, wherein determining the filtered signal based at least on the unfiltered target signal, the first noise signal, and the second noise signal comprises determining the filtered signal such that the filtered signal to noise ratio is higher than the unfiltered signal to noise ratio.

2. The method of claim 1 wherein the medical diagnostic device comprises a source configured to illuminate an analyte within the lumen such that the analyte emits emission light, and the method further comprising:

spectrally separating at least a portion of the emission light into at least a first spectral band and a second spectral band, wherein the first optical signal comprises at least a portion of the first spectral band, wherein detecting the first optical signal comprises using the optical detector to detect the first optical signal.

3. The method of claim 2 wherein the analyte comprises at least one fluorophore that fluoresces within the first spectral band when illuminated by the source.

4. The method of claim 1 wherein the medical diagnostic device comprises a source, the method further comprising:

illuminating the lumen with the source; and

modulating the first and second noise signals.

5. The method of claim 1, wherein detecting, by the at least one optical detector, the first optical signal comprises operating a first optical detector at a first location to detect the first optical signal, wherein detecting, by the at least one optical detector, the second optical signal comprises operating a second optical detector at a second location to detect the second optical signal, and wherein the first and second locations differ.

6. The method of claim 1, wherein detecting, by the at least one optical detector, the first optical signal comprises operating a first light source of the device to illuminate the first portion of the lumen of subsurface vasculature, and wherein detecting, by the at least one optical detector, the second optical signal comprises operating a second light source of the device to illuminate the second portion of the lumen of subsurface vasculature.

7. A medical diagnostic device, comprising:

at least one optical detector configured to detect an unfiltered target signal, a first noise signal, and a second noise signal, wherein the unfiltered target signal and first noise signal are transmitted through a skin surface from within a first portion of a lumen of subsurface vasculature, wherein the second noise signal is transmitted through the skin surface from within a second portion of the lumen of subsurface vasculature, wherein the first and second noise signals are correlated, and wherein a quotient of the unfiltered target signal and the first noise signal comprises an unfiltered signal to noise ratio; and

a computing device configured to;

determine a filtered signal, based at least on the unfiltered target signal, the first noise signal, and the second noise signal, wherein the filtered signal comprises a filtered target signal and a filtered noise signal, and wherein a quotient of the filtered target signal and the filtered noise signal comprises a filtered signal to noise ratio, wherein determining the filtered signal based at least on the unfiltered target signal, the first noise signal, and the second noise signal comprises determining the filtered signal such that the filtered signal to noise ratio is higher than the unfiltered signal to noise ratio.

8. The medical diagnostic device of claim 7, wherein the medical diagnostic device further comprises:

a source configured to illuminate an analyte within the lumen such that the analyte emits emission light, wherein the medical diagnostic device is further configured to;

spectrally separate at least a portion of the emission light from the first portion of the lumen of subsurface vasculature into at least a first spectral band and a second spectral band, wherein the computing device is further configured to detect at least a portion of the first spectral band with the at least one optical detector.

9. The medical diagnostic device of claim 7, wherein the at least one optical detector comprises a first optical detector that receives, at a first location, the unfiltered target signal and first noise signal from the first portion of the lumen of subsurface vasculature, wherein the at least one optical detector further comprises a second optical detector that receives, at a second location, the second noise signal from the second portion of the lumen of subsurface vasculature, and wherein the first and second locations differ.

10. The medical diagnostic device of claim 7, further comprising a first light source configured to illuminate the first portion of the lumen of subsurface vasculature and a second light source configured to illuminate the second portion of the lumen of subsurface vasculature.

11. A non-transitory computer readable medium having stored therein instructions executable by a computing device to cause the computing device to perform operations comprising:

detecting, by at least one optical detector in a medical diagnostic device, a first optical signal transmitted through a skin surface from within a first portion of a lumen of subsurface vasculature and a second optical signal transmitted through the skin surface from within a second portion of the lumen of subsurface vasculature, wherein the first optical signal comprises an unfiltered target signal and a first noise signal and the second optical signal comprises a second noise signal, wherein the first and second noise signals are correlated and wherein a quotient of the unfiltered target signal and the first noise signal comprises an unfiltered signal to noise ratio; and

determining a filtered signal, based at least on the unfiltered target signal, the first noise signal, and the second noise signal, wherein the filtered signal comprises a filtered target signal and a filtered noise signal, and wherein a quotient of the filtered target signal and the filtered noise signal comprises a filtered signal to noise ratio, wherein determining the filtered signal based at least on the unfiltered target signal, the first noise signal, and the second noise signal comprises determining the filtered signal such that the filtered signal to noise ratio is higher than the unfiltered signal to noise ratio.

12. The non-transitory computer readable medium of claim 11, wherein the medical diagnostic device comprises a source configured to illuminate an analyte within the lumen such that the analyte emits emission light, and the operations further comprising:

causing at least a portion of the emission light to be spectrally separated into at least a first spectral band and a second spectral band; and

detecting the first optical signal using the optical detector, wherein the first optical signal comprises at least a portion of the first spectral band.

13. The non-transitory computer readable medium of claim 11, wherein detecting, by the at least one optical detector, the first optical signal comprises operating a first optical detector at a first location to detect the first optical signal, wherein detecting, by the at least one optical detector, the second optical signal comprises operating a second optical detector at a second location to detect the second optical signal, and wherein the first and second locations differ.

14. The non-transitory computer readable medium of claim 11, wherein detecting, by the at least one optical detector, the first optical signal comprises operating a first light source of the device to illuminate the first portion of the lumen of subsurface vasculature, and wherein detecting, by the at least one optical detector, the second optical signal comprises operating a second light source of the device to illuminate the second portion of the lumen of subsurface vasculature.