Implantable prosthesis having acellular tissue attachments

• US 10,039,633 B2
• Filed: 06/18/2013
• Issued: 08/07/2018
• Est. Priority Date: 06/21/2012
• Status: Active Grant

• Current Assignee: Lifecell Corporation (Abbvie Incorporated)
• Original Assignee: Lifecell Corporation (Abbvie Incorporated)
• Inventors: Ansorge, Heather, Lapitan, Lawrence, Hayzlett, Mark, Kabaria, Nimesh, Hull, Raymond, Sun, Wenquan, Taenzer, Michael, Amato, Matthew, Roock, Timothy, Lee, Dennis
• Primary Examiner(s): IWAMAYE, ANDREW MICHAEL
• Application Number:
  US14/406,263
• Publication Number:
  US 20150150674A1
• Time in Patent Office: 1,876 Days
• CPC Class Codes: A61B 90/02 Devices for expanding tissue, e.g. skin tissue implements for holding wounds open, surgical tractors A61B17/02; implantable mammary prosthesis A61F2/12; dilators A61M29/00
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2210/009 magnetic
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0025 Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2220/0033 made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2220/0091 connected by a hinged linkage mechanism, e.g. of the single-bar or multi-bar linkage type
• CPC Class Codes: A61F 2230/0004 Rounded shapes, e.g. with rounded corners
• CPC Class Codes: A61F 2230/0045 Omega-shaped
• CPC Class Codes: A61F 2230/0086 Pyramidal, tetrahedral, or wedge-shaped
• CPC Class Codes: A61F 2230/0089 tetrahedral, i.e. having a triangular basis
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas
• CPC Class Codes: A61F 2250/0024 made from both porous and non-porous parts, e.g. adjacent parts
• CPC Class Codes: A61F 2250/0031 made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2250/0071 : breakable or frangible

Abstract

A prosthesis comprising a tissue expander and one or more samples of graft material, wherein the tissue expander is attached to the one or more samples of graft material in a manner that allows the tissue expander and the one or more samples of graft material to be implanted in a patient as a unitary prosthesis; and wherein tissue expander is attached to the one or more samples of graft material in a manner that will allow the tissue expander and the graft material to separate after a period of time following implantation to allow removal of the tissue expander from an implant sites while leaving the graft material within the implant site, the prosthesis comprises a tissue expander having molded grooves, slots, channels, or other shallow cavity spaces on a surface, and wherein the graft material is within the grooves, slots, channels, or other shallow cavity spaces, securing the graft material to the tissue expander.

Claims

1. A prosthesis comprising:

a tissue expander comprising molded grooves, slots, or channels on a surface of the tissue expander; and

one or more samples of graft material comprising adipose tissue matrix releasably coupleable to the tissue expander in a manner that allows the tissue expander and the adipose tissue matrix to be implanted in a patient as a unitary prosthesis,

wherein the adipose tissue matrix further comprises shaped protrusions that conform to the inner surfaces of the grooves, slots, or channels on the surface of the tissue expander to releasably couple the adipose tissue matrix to the tissue expander, and

wherein the adipose tissue matrix is configured to release from the tissue expander as the tissue expander is enlarged after implantation.

2. The prosthesis of claim 1, wherein the adipose tissue matrix comprises an acellular adipose tissue matrix.

3. The prosthesis of claim 2, wherein the adipose acellular tissue matrix has been treated to produce a three-dimensional porous or sponge-like material.

4. The prosthesis of claim 1, wherein the adipose tissue matrix is configured to release from the tissue expander as a frictional force holding the adipose tissue matrix in place lessens after implantation.

5. The prosthesis of claim 1, wherein the adipose tissue matrix is configured to release from the molded slots, grooves, or channels as the tissue expander is filled after implantation, thereby stretching the edges of the molded slots, grooves, or channels and removing a frictional force coupling the adipose tissue matrix to the tissue expander.

6. The prosthesis of claim 1, wherein the shaped protrusions are configured to release from the molded slots, grooves, or channels as the tissue expander or the adipose tissue matrix deforms following implantation thereby lessening a frictional force coupling the adipose tissue matrix to the tissue expander.