Ear stimulation with neural feedback sensing

• US 10,039,928 B2
• Filed: 03/27/2015
• Issued: 08/07/2018
• Est. Priority Date: 03/27/2015
• Status: Expired due to Fees

• Current Assignee: Aurenar Incorporated
• Original Assignee: Equality, LLC
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Kare, Jordin T., Leuthardt, Eric C., Malamud, Mark A., Malaska, Stephen L., Myhrvold, Nathan P., Sweeney, Elizabeth A., Tegreene, Clarence T., Whitmer, Charles, Wood, Jr., Lowell L., Wood, Victoria Y. H.
• Primary Examiner(s): Matthews, Christine H
• Assistant Examiner(s): LANNU, JOSHUA DARYL DEANON
• Application Number:
  US14/670,504
• Publication Number:
  US 20160279435A1
• Time in Patent Office: 1,229 Days
• CPC Class Codes: A61H 2201/0188 Illumination related features
• CPC Class Codes: A61H 2201/02 heated or cooled
• CPC Class Codes: A61H 2201/10 with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
• CPC Class Codes: A61H 2201/1604 Head
• CPC Class Codes: A61H 2201/165 Wearable interfaces
• CPC Class Codes: A61H 2201/501 connected to external computer devices or networks
• CPC Class Codes: A61H 2201/5012 using the internet
• CPC Class Codes: A61H 2201/5046 Touch screens
• CPC Class Codes: A61H 2201/5058 Sensors or detectors
• CPC Class Codes: A61H 2201/5064 Position sensors
• CPC Class Codes: A61H 2201/5082 Temperature sensors
• CPC Class Codes: A61H 2201/5092 Optical sensor
• CPC Class Codes: A61H 2201/5097 wireless
• CPC Class Codes: A61H 2205/027 Ears
• CPC Class Codes: A61H 2230/00 Measuring physical parameters of the user
• CPC Class Codes: A61H 2230/065 used as a control parameter for the apparatus
• CPC Class Codes: A61H 2230/105 used as a control parameter for the apparatus
• CPC Class Codes: A61H 2230/305 used as a control parameter for the apparatus A61H2230/045 takes precedence
• CPC Class Codes: A61H 2230/405 used as a control parameter for the apparatus
• CPC Class Codes: A61H 2230/605 used as a control parameter for the apparatus
• CPC Class Codes: A61H 2230/655 : used as a control parameter for the apparatus
• CPC Class Codes: A61H 23/02 : with electric or magnetic drive
• CPC Class Codes: A61H 23/0236 : using sonic waves, e.g. using loudspeakers
• CPC Class Codes: A61H 23/0245 : with ultrasonic transducers, e.g. piezoelectric
• CPC Class Codes: A61N 1/0456 : Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0472 : Structure-related aspects
• CPC Class Codes: A61N 1/36021 : for treatment of pain
• CPC Class Codes: A61N 1/36025 : for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36031 : using physiological parameters for adjustment
• CPC Class Codes: A61N 1/36036 : of the outer, middle or inner ear
• CPC Class Codes: A61N 1/37247 : User interfaces, e.g. input or presentation means
• CPC Class Codes: A61N 2/002 : in combination with another treatment
• CPC Class Codes: A61N 2/006 : for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 7/00 : Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A63F 13/212 : using sensors worn by the player, e.g. for measuring heart beat or leg activity
• CPC Class Codes: A63F 13/424 : involving acoustic input signals, e.g. by using the results of pitch or rhythm extraction or voice recognition

Abstract

Systems and related methods for delivering a stimulus to a pinna of a subject with a stimulator worn on the pinna are described. A wearable stimulation device includes a mechanical, electrical, or other type of stimulator secured to a pinna of a subject. The stimulation device may be used to deliver a stimulus that modulates activity of sensory nerve fiber innervating the pinna. Stimulation may be delivered in response to a sensed neural signal indicative of a physiological status of the subject, and/or in response to sensed environmental parameters. Stimulation may be delivered in combination with other stimuli or experiences. In an aspect, a stimulator communicates with and/or is controlled by a personal computing device.

Claims

1. A neural stimulation system comprising:

a neural signal sensor adapted to sense a neural signal from a subject, the neural signal indicative of a physiological status of the subject, wherein the neural signal sensor is an electroencephalographic signal sensor or an electrooculographic signal sensor;

at least one neural stimulator adapted to produce a stimulus responsive to the sensed neural signal, the stimulus configured to activate at least one sensory nerve fiber innervating at least a portion of a pinna of the subject, the portion of the pinna including at least one of a cymba concha and a cavum concha, the at least one neural stimulator including at least one of a neural stimulator configured for placement on the cymba concha and a neural stimulator configured for placement on the cavum concha; and

a securing member configured to secure the at least one neural stimulator to the at least one of the cymba concha and the cavum concha.

2. The system of claim 1, further comprising a clock or timer.

3. The system of claim 2, wherein the at least one neural stimulator is adapted to produce the stimulus based at least in part on at least one of a time of day indicated by the clock or timer and a date indicated by the clock or timer.

4. The system of claim 1, further comprising at least one secondary stimulator adapted to deliver a secondary stimulus to the subject.

5. The system of claim 1, further comprising a sound source for delivering an auditory signal to the subject.

6. The system of claim 1, further comprising a position sensor for sensing a position of the at least one neural stimulator with respect to the pinna of the subject.

7. The system of claim 1, wherein the physiological status of the subject includes at least one of a brain-related disorder in the subject, an inflammatory condition in the subject, a depressed condition of the subject, an epileptic seizure in the subject, and a headache in the subject.

8. The system of claim 1, wherein the securing member includes at least one of a shape memory material, an ear canal insert, a concha-fitted portion, a hanger-style securing member, loop-style securing member, a clip, a housing, and an extension.

9. The system of claim 1, wherein the at least one neural stimulator includes at least one of a vibratory mechanical stimulator, a transcutaneous electrical stimulator, a transcutaneous magnetic stimulator and an ultrasonic stimulator.

10. The system of claim 1, including at least one second sensor.

11. The system of claim 10, wherein the at least one second sensor includes at least one of a secondary neural signal sensor, a physiological sensor, a motion sensor, a location sensor, and an environmental sensor.

12. The system of claim 10, wherein the at least one second sensor includes at least one physiological sensor, wherein the at least one physiological sensor includes at least one of a heart rate sensor, an electromyographic sensor, a blood pressure sensor, a perspiration sensor, a skin conductivity sensor, a respiration sensor, a pupil dilation sensor, a digestive tract activity sensor, and a piloerection sensor.

13. The system of claim 10, wherein the at least one second sensor includes at least one environmental sensor, wherein the at least one environmental sensor includes at least one of a light sensor, a temperature sensor, and an acoustic sensor.

14. The system of claim 1, wherein the at least one neural stimulator includes a neural stimulator configured for placement on the cavum concha, and wherein the securing member is configured to secure the at least one neural stimulator to the cavum concha.

15. The system of claim 1, wherein the at least one neural stimulator includes a neural stimulator configured for placement on the cymba concha, and wherein the securing member is configured to secure the at least one neural stimulator to the cymba concha.

16. The system of claim 1, wherein the at least one neural stimulator includes a first neural stimulator configured for placement on the cavum concha and a second neural stimulator configured for placement on the cymba concha, and wherein the securing member is configured to secure the first neural stimulator to the cavum concha and to secure the second neural stimulator to the cymba concha.

17. The system of claim 1, further comprising an ear canal insert configured to fit in an ear canal of the subject and having an additional neural stimulator positioned on the ear canal insert.

18. A method comprising:

sensing with a neural signal sensor a neural signal indicative of a physiological status of a subject, the neural signal sensor located in or on a portion of a body of the subject, wherein the neural signal is an electroencephalographic signal or an electrooculographic signal;

determining with signal analysis circuitry at least one parameter of the sensed neural signal; and

delivering a neural stimulus with a neural stimulation device worn on a pinna of the subject responsive to the sensed neural signal, wherein the neural stimulation device includes at least one of neural stimulator located on a cymba concha and a neural stimulator located on a cavum concha of the subject, wherein the neural stimulus is configured to modulate an activity of at least one sensory nerve fiber innervating at least a portion of the pinna of the subject including at least one of the cymba concha and the cavum concha.

19. The method of claim 18, wherein the neural stimulus is configured to activate the at least one sensory nerve fiber innervating the at least a portion of the pinna of the subject.

20. The method of claim 18, including modulating delivery of the neural stimulus responsive to the at least one sensed neural signal parameter.

21. The method of claim 18, including sensing at least one secondary signal with a secondary sensor and controlling the delivery of the neural stimulus based at least in part on the sensed secondary signal.

22. The method of claim 21, wherein controlling the delivery of the neural stimulus based at least in part on the sensed secondary signal includes at least one of modulating delivery of the neural stimulus in response to the sensed secondary signal, initiating delivery of the neural stimulus in response to the sensed secondary signal, and discontinuing delivery of the neural stimulus in response to the sensed secondary signal.

23. The method of claim 21, wherein the at least one secondary signal includes at least one of a secondary neural signal, a physiological signal, a heart rate signal, an electromyographic signal, a blood pressure signal, a signal indicative of perspiration or skin conductivity of the subject, a signal indicative of respiration of the subject, a signal indicative of dilation of a pupil of the subject, a signal indicative of digestive tract activity of the subject, a signal indicative of piloerection of the subject, a signal from a motion sensor, a signal from a location sensor, an environmental signal from an environmental sensor, an environmental signal indicative of a light level, an environmental signal indicative of a length of a day, an environmental signal indicative of a temperature, an environmental signal indicative of an ambient noise level, a signal indicative of delivery of a pharmaceutical to a user, a signal indicative of delivery of a nutraceutical to a user, a signal indicative of a user input to a computing device, a signal indicative of a user input to a computing device in response to a query or prompt, a signal indicative of a user input to a game, a signal indicative of an event in a game played by the subject, a signal indicative of a user input provided to a virtual reality system by the subject, a signal indicative of an event experienced by the subject in a virtual reality system, a signal indicative of a user input to a computing device, a signal indicative of health-related information of the subject, a signal indicative of genome information of the subject, and a signal indicative of microbiome information of the subject.

24. The method of claim 18, further comprising receiving a secondary signal from a secondary signal input.

25. The method of claim 18, including delivering at least one secondary stimulus to the subject.

26. The method of claim 25, wherein the at least one secondary stimulus includes at least one of a secondary neural stimulus, a mechanical stimulus, music, an auditory stimulus, a virtual reality experience, an augmented reality experience, a visual stimulus, a tactile stimulus, a haptic stimulus, an olfactory stimulus, an interaction of the subject with a virtual therapist, an interaction of the subject with a therapy provider, delivery of a drug to the subject, and delivery of a nutraceutical to the subject.

27. The method of claim 18, including sensing a position of the neural stimulation device relative to the pinna of subject with a position sensor operatively connected to the neural stimulation device.

28. The method of claim 18, including detecting at least one symptom of a brain-related disorder in the subject based upon the at least one parameter of the sensed neural signal and delivering the neural stimulus in response to detection of the at least one symptom of the brain-related disorder.

29. The method of claim 18, wherein the physiological status of the subject includes at least one of a brain-related disorder in the subject, an inflammatory condition in the subject, a depressed condition of the subject, an epileptic seizure in the subject, and a headache in the subject.

30. The method of claim 18, wherein the at least one parameter of the sensed neural signal includes at least one of a frequency content of an electroencephalographic signal, an amplitude of an electroencephalographic signal, a rate of eye movement determined from an electrooculographic signal, and a gaze direction determined from an electrooculographic signal.

31. The method of claim 18, wherein at least one of the neural stimulus and the neural stimulation device is configured to activate at least one of cranial nerve, a vagus nerve, a facial nerve, a trigeminal nerve, and a glossopharyngeal nerve.

32. The method of claim 18, wherein the neural stimulus includes at least one of a mechanical stimulus, a vibratory mechanical stimulus, a transcutaneous electrical stimulus, a transcutaneous magnetic stimulus, and an ultrasonic stimulus.

33. The method of claim 18, wherein the neural stimulus has a frequency between 1 Hz and 1000 Hz, between 10 Hz and 500 Hz, between 30 Hz and 40 Hz, between 10 Hz and 50 Hz, between 10 Hz and 80 Hz, between 50 Hz and 100 Hz, or between 200 and 300 Hz.

34. The method of claim 18, wherein the neural stimulus includes at least one of a stimulus delivered according to a programmed pattern, a continuously-delivered stimulus, an intermittently-delivering stimulus, a time-varying stimulus, and a pulsed stimulus.

35. The method of claim 18, including at least one of controlling the neural stimulation device with control circuitry located at least in part on the neural stimulation device worn on the pinna of the subject, controlling the neural stimulation device with control circuitry located at least in part on a personal computing device in communication with the neural stimulation device worn on the pinna of the subject, sending a signal from the neural stimulation device worn on the pinna of the subject to a personal computing device, receiving a signal from a personal computing device at the neural stimulation device worn on the pinna of the subject, delivering an auditory instruction to the subject with a sound source operatively connected to the neural stimulation device, delivering an auditory alert to the subject with a sound source operatively connected to the neural stimulation device, and delivering a visual alert to the subject.

36. A neural stimulation system comprising:

a wearable neural stimulation device including

a neural stimulator configured to activate at least one sensory nerve fiber innervating at least a portion of a pinna of a subject using a stimulus;

a securing member configured to secure the neural stimulator to the pinna;

first control circuitry incorporated into the wearable neural stimulation device for controlling operation of the neural stimulator; and

first communication circuitry incorporated into the wearable neural stimulation device and operatively connected to the control circuitry, the first communication circuitry configured for at least one of sending a signal to and receiving a signal from a personal computing device; and

the personal computing device, wherein the personal computing device includes

a user interface for at least one of presenting information to and receiving information from a user;

second control circuitry operatively connected to the user interface;

second communication circuitry configured for at least one of sending a signal to and receiving a signal from the first communication circuitry; and

instructions that when executed on the personal computing device cause the personal computing device to perform at least one of sending a signal to and receiving a signal from the wearable neural stimulation device via the second communication circuitry.

37. The neural stimulation system of claim 36, including a housing, wherein at least one of the neural stimulator, the first control circuitry, and the first communication circuitry is housed within the housing.

38. The neural stimulation system of claim 36, further comprising at least one sensor.

39. The neural stimulation system of claim 38, wherein the at least one sensor includes at least one of a neural signal sensor, a physiological sensor, a motion sensor, a location sensor, an environmental sensor, a light sensor, a temperature sensor, and an acoustic sensor.

40. The neural stimulation system of claim 36, further comprising a secondary signal input, wherein the neural stimulator is adapted to produce the stimulus based at least in part on a signal received at the secondary signal input.

41. The neural stimulation system of claim 36, further comprising at least one secondary stimulator adapted to deliver a secondary stimulus to the subject.

42. The neural stimulation system of claim 41, wherein the at least one secondary stimulator includes at least one of a neural stimulator, a mechanical stimulator, an audio player, an auditory stimulus source, a virtual reality system, augmented reality system, a visual stimulus source, a tactile stimulator, a haptic stimulator, an odorant source, a computing system configured to deliver a virtual therapist experience, a drug delivery device, and a nutraceutical delivery device.

43. The neural stimulation system of claim 36, wherein the first control circuitry incorporated into the wearable neural stimulation device is carried by the securing member.

44. The neural stimulation system of claim 36, further comprising a sound source for delivering an auditory signal to the subject.

45. The neural stimulation system of claim 36, wherein the personal computing device includes at least one of a personal digital assistant, a personal entertainment device, a mobile phone, a laptop computer, a wearable computing device, a tablet personal computer, a networked computer, a cluster of processors, a cluster of servers, a workstation computer, and a desktop computer.