Fibronectin type III domain based scaffold compositions, methods and uses
First Claim
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1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding a protein scaffold comprising the amino acid sequence of SEQ ID NO:
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Abstract
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
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Citations
12 Claims
- 1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding a protein scaffold comprising the amino acid sequence of SEQ ID NO:
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9. An isolated nucleic acid molecule comprising a nucleotide sequence encoding a protein scaffold based on a fibronectin type III (FN3) domain comprising:
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a backbone portion having an amino acid sequence identical to SEQ ID NO;
16 at residues 1-21, 29-74, and 82-89;a B;
C loop portion between residues 21 and 29 of SEQ ID NO;
16 having at least 75% identity to residues 22-28 of the amino acid sequence of SEQ ID NO;
16; andan F;
G loop portion between residues 74 and 82 of SEQ ID NO;
16 having at least 75% identity to residues 75-81 of the amino acid sequence of SEQ ID NO;
16. - View Dependent Claims (10, 11, 12)
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Specification