Methods and kits for predicting a response to an erythropoietic agent
First Claim
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1. A method for predicting a response to an erythropoietic agent in a subject, comprising:
- (a) providing a biological sample from a subject who has been previously administered a dose amount of an erythropoietic agent;
(b) measuring an amount in the sample of the peptide consisting of SEQ ID NO;
15;
(c) comparing the amount of the peptide in the sample to a control level of the peptide;
(d) predicting that the subject will have a poor response to the erythropoietic agent when there is a measurable increase in the amount of the peptide consisting of SEQ ID NO;
15 in the sample as compared to the control level; and
(e) modifying the dose amount of the erythropoietic agent being administered to the subject by administering an increased dose amount of the erythropoietic agent to the subject predicted to have a poor response to the erythropoietic agent in (d), wherein the increased dose amount of the erythropoietic agent is increased as compared to the dose amount of the erythropoietic agent previously administered to the subject.
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Abstract
Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent.
9 Citations
13 Claims
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1. A method for predicting a response to an erythropoietic agent in a subject, comprising:
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(a) providing a biological sample from a subject who has been previously administered a dose amount of an erythropoietic agent; (b) measuring an amount in the sample of the peptide consisting of SEQ ID NO;
15;(c) comparing the amount of the peptide in the sample to a control level of the peptide; (d) predicting that the subject will have a poor response to the erythropoietic agent when there is a measurable increase in the amount of the peptide consisting of SEQ ID NO;
15 in the sample as compared to the control level; and(e) modifying the dose amount of the erythropoietic agent being administered to the subject by administering an increased dose amount of the erythropoietic agent to the subject predicted to have a poor response to the erythropoietic agent in (d), wherein the increased dose amount of the erythropoietic agent is increased as compared to the dose amount of the erythropoietic agent previously administered to the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for determining whether to modify an amount of an erythropoietic agent administered to a subject, comprising:
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(a) providing a series of biological samples over a time period from a subject who has been previously administered a dose amount of an erythropoietic agent; (b) analyzing the series of biological samples to measure an amount of the peptide consisting of SEQ ID NO;
15 in each of the biological samples;(c) comparing any measurable change in amounts of the peptide in each of the biological samples over the time period; (d) identifying the subject as being in need of an administration of an increased amount of the erythropoietic agent if there is a measurable increase in the amount of the peptide over the time period; and (e) modifying the amount of the erythropoietic agent being administered to the subject by administering an increased dose amount of the erythropoietic agent to the subject identified as being in need in (d), wherein the increased dose amount of the erythropoietic agent is increased as compared to the dose amount of the erythropoietic agent previously administered to the subject. - View Dependent Claims (9, 10, 11, 12, 13)
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Specification