Zwitterion surface modifications for continuous sensors
First Claim
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1. A device for measurement of a glucose concentration, the device comprising:
- a sensor configured to generate a signal indicative of a glucose concentration; and
a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain, wherein the outermost domain comprises a copolymer, wherein the copolymer comprises at least one betaine compound or a derivative thereof, wherein the copolymer comprises both hydrophilic and hydrophobic regions, wherein an amount of the at least one betaine compound or the derivative thereof in the outermost domain is from about 1% wt. to about 50% wt. of the outermost domain.
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Abstract
Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.
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Citations
24 Claims
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1. A device for measurement of a glucose concentration, the device comprising:
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a sensor configured to generate a signal indicative of a glucose concentration; and a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain, wherein the outermost domain comprises a copolymer, wherein the copolymer comprises at least one betaine compound or a derivative thereof, wherein the copolymer comprises both hydrophilic and hydrophobic regions, wherein an amount of the at least one betaine compound or the derivative thereof in the outermost domain is from about 1% wt. to about 50% wt. of the outermost domain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A device for measurement of a glucose concentration, the device comprising:
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a sensor configured to generate a signal indicative of a glucose concentration; and a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain, wherein the outermost domain comprises a copolymer, wherein the copolymer comprises at least one betaine compound or a derivative thereof, wherein the copolymer comprises both hydrophilic and hydrophobic regions, wherein an amount of the at least one betaine compound or the derivative thereof in the outermost domain is from about 10% wt. to about 40% wt. of the outermost domain. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification