Method for formulating large diameter synthetic membrane vesicles
First Claim
1. A process for preparing droplets using an atomizing nozzle apparatus, wherein the apparatus comprises:
- a first fluid conduit, a second fluid conduit, a third fluid conduit, and a fourth fluid conduit each having at least one entrance orifice and at least one exit orifice;
a first fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and said at least one entrance orifice connecting to the at least one exit orifice of the first fluid conduit and the at least one exit orifice of the second fluid conduit, wherein the second fluid conduit annularly surrounds a portion of the first fluid conduit, wherein the first fluid contacting chamber conically tapers from the top of the first fluid contacting chamber to the bottom of the first fluid contacting chamber;
a second fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and said at least one entrance orifice connecting to the at least one exit orifice of the first fluid contacting chamber and the at least one exit orifice of the third fluid conduit, wherein the third fluid conduit annularly surrounds a portion of the first fluid contacting chamber and wherein the diameter of the second fluid contacting chamber conically tapers from its top to its bottom, wherein the first and second fluid contacting chambers are hydraulic extrusion cones; and
the fourth fluid conduit, wherein the fourth fluid conduit annularly surrounds a portion of the second fluid contacting chamber,wherein the process for preparing droplets comprises;
applying a first liquid to the first fluid conduit;
applying a second liquid to the second fluid conduit;
applying a third liquid to the third fluid conduit; and
applying a gas to the fourth fluid conduit,wherein the gas exiting the fourth fluid conduit exit orifice impinges the liquid exiting the at least one exit orifice of the second fluid contacting chamber, providing atomized droplets, wherein the droplets have an average diameter from about 100 nm to about 100 μ
M.
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Accused Products
Abstract
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
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Citations
26 Claims
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1. A process for preparing droplets using an atomizing nozzle apparatus, wherein the apparatus comprises:
- a first fluid conduit, a second fluid conduit, a third fluid conduit, and a fourth fluid conduit each having at least one entrance orifice and at least one exit orifice;
a first fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and said at least one entrance orifice connecting to the at least one exit orifice of the first fluid conduit and the at least one exit orifice of the second fluid conduit, wherein the second fluid conduit annularly surrounds a portion of the first fluid conduit, wherein the first fluid contacting chamber conically tapers from the top of the first fluid contacting chamber to the bottom of the first fluid contacting chamber; a second fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and said at least one entrance orifice connecting to the at least one exit orifice of the first fluid contacting chamber and the at least one exit orifice of the third fluid conduit, wherein the third fluid conduit annularly surrounds a portion of the first fluid contacting chamber and wherein the diameter of the second fluid contacting chamber conically tapers from its top to its bottom, wherein the first and second fluid contacting chambers are hydraulic extrusion cones; and the fourth fluid conduit, wherein the fourth fluid conduit annularly surrounds a portion of the second fluid contacting chamber, wherein the process for preparing droplets comprises; applying a first liquid to the first fluid conduit; applying a second liquid to the second fluid conduit; applying a third liquid to the third fluid conduit; and applying a gas to the fourth fluid conduit, wherein the gas exiting the fourth fluid conduit exit orifice impinges the liquid exiting the at least one exit orifice of the second fluid contacting chamber, providing atomized droplets, wherein the droplets have an average diameter from about 100 nm to about 100 μ
M. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
- a first fluid conduit, a second fluid conduit, a third fluid conduit, and a fourth fluid conduit each having at least one entrance orifice and at least one exit orifice;
Specification