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Method for formulating large diameter synthetic membrane vesicles

  • US 10,045,941 B2
  • Filed: 03/06/2013
  • Issued: 08/14/2018
  • Est. Priority Date: 04/09/2010
  • Status: Active Grant
First Claim
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1. A process for preparing droplets using an atomizing nozzle apparatus, wherein the apparatus comprises:

  • a first fluid conduit, a second fluid conduit, a third fluid conduit, and a fourth fluid conduit each having at least one entrance orifice and at least one exit orifice;

    a first fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and said at least one entrance orifice connecting to the at least one exit orifice of the first fluid conduit and the at least one exit orifice of the second fluid conduit, wherein the second fluid conduit annularly surrounds a portion of the first fluid conduit, wherein the first fluid contacting chamber conically tapers from the top of the first fluid contacting chamber to the bottom of the first fluid contacting chamber;

    a second fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and said at least one entrance orifice connecting to the at least one exit orifice of the first fluid contacting chamber and the at least one exit orifice of the third fluid conduit, wherein the third fluid conduit annularly surrounds a portion of the first fluid contacting chamber and wherein the diameter of the second fluid contacting chamber conically tapers from its top to its bottom, wherein the first and second fluid contacting chambers are hydraulic extrusion cones; and

    the fourth fluid conduit, wherein the fourth fluid conduit annularly surrounds a portion of the second fluid contacting chamber,wherein the process for preparing droplets comprises;

    applying a first liquid to the first fluid conduit;

    applying a second liquid to the second fluid conduit;

    applying a third liquid to the third fluid conduit; and

    applying a gas to the fourth fluid conduit,wherein the gas exiting the fourth fluid conduit exit orifice impinges the liquid exiting the at least one exit orifice of the second fluid contacting chamber, providing atomized droplets, wherein the droplets have an average diameter from about 100 nm to about 100 μ

    M.

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