Control of a peripheral device with a bandage-type analyte sensor

• US 10,046,114 B1
• Filed: 05/22/2015
• Issued: 08/14/2018
• Est. Priority Date: 05/22/2015
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Biederman, William James, Otis, Brian, Wasson, Jaclyn Leverett, Liu, Zenghe
• Primary Examiner(s): Farrar, Lauren P
• Application Number:
  US14/719,980
• Time in Patent Office: 1,180 Days
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 5/0024 for multiple sensor units attached to the patient, e.g. using a body or personal area network
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

An example system includes a flexible substrate configured to be mounted to a skin surface. The system includes a sensor probe that has a first end attached to the flexible substrate and a second end configured to extend beneath the skin surface to contact interstitial fluid. A sensor is configured to measure a physiological property and is disposed at the second end of the sensor probe. A transmitter is attached to the flexible substrate and is configured to provide information related to sensor measurements to a controller. The controller is configured to a drug delivery rate based on the information.

Claims

1. A system comprising:

a flexible substrate configured to be mounted to a skin surface;

a sensor probe having a first end attached to the flexible substrate and a second end configured to extend beneath the skin surface to contact interstitial fluid;

a sensor configured to measure a physiological property, wherein the sensor is disposed at the second end of the sensor probe, and wherein the physiological property is related to glucose in the interstitial fluid;

a controller; and

a near field communication (NFC) device mounted to the flexible substrate and electrically coupled to the sensor, wherein the NFC device is configured to receive from the sensor one or more sensor measurements indicative of the physiological property, and wherein the NFC device is configured to detect the controller and provide information related to the one or more sensor measurements to the controller in response to detecting the controller,

wherein the controller is configured to;

(i) receive the information related to the one or more sensor measurements from the NFC device, (ii) determine a glucose concentration based on the information, (iii) obtain a target glucose concentration, (iv) compare the glucose concentration to the target glucose concentration, and (v) based on the comparing, provide instructions to an insulin delivery device to control an insulin delivery rate to a blood stream by the insulin delivery device.

2. The system of claim 1, further comprising an adhesive layer disposed on the flexible substrate, wherein the adhesive layer is configured to adhere the flexible substrate to the skin surface.

3. The system of claim 1, wherein the flexible substrate comprises polyimide.

4. The system of claim 1, wherein the NFC device includes an antenna disposed on the flexible substrate, wherein the NFC device is configured to communicate the information related to the one or more sensor measurements to the controller by way of the antenna.

5. The system of claim 1, wherein the NFC device is configured to periodically communicate the information related to the one or more sensor measurements to the controller without receiving commands from the controller.

6. The system of claim 1, wherein the controller is further configured to provide an alert after a particular period of time lapses without receiving the information from the NFC device.

7. The system of claim 1, wherein the sensor comprises two electrodes and is configured to measure the physiological property electrochemically.

8. The system of claim 1, wherein the controller is integrated into the insulin delivery device, the system further comprising:

an NFC receiver coupled to the insulin delivery device and configured to receive the information related to the one or more sensor measurements from the NFC device and provide the information to the controller.

9. A method comprising:

receiving, at a controller from a near filed communication (NFC) device, information indicative of one or more sensor measurements of a physiological property related to glucose in an interstitial fluid, wherein;

the NFC device is mounted to a flexible substrate mounted to a skin surface, the one or more sensor measurements are captured by a sensor disposed at a first end of a sensor probe, the first end being configured to extend beneath the skin surface to contact the interstitial fluid, and the sensor probe having a second end attached to the flexible substrate, and wherein the NFC device is configured to detect the controller and provide the information to the controller in response to detecting the controller;

determining a glucose concentration based on the information;

obtaining a target glucose concentration;

comparing the glucose concentration to the target glucose concentration; and

based on the comparing, providing instructions to an insulin delivery device to control an insulin delivery rate to a blood stream by the insulin delivery device.

10. The method of claim 9, further comprising:

establishing a rate of change of glucose concentration based on the one or more sensor measurements, wherein the instructions to the insulin delivery device are further based on the established rate of change of glucose concentration.

11. The method of claim 9, wherein the controller has access to patient-specific information, the method further comprising:

establishing a range of glucose concentration about the target glucose concentration based on the patient-specific information, wherein providing the instructions to the insulin delivery device comprises;

providing instructions for maintaining a predetermined insulin delivery rate by the insulin delivery device when the glucose concentration is within the range; and

providing instructions for changing the insulin delivery rate by the insulin delivery device when the glucose concentration is outside of the range.

12. The method of claim 9, further comprising:

generating an alert after a particular period of time lapses without receiving the information from the NFC device.

13. The method of claim 9, wherein the controller is integrated into the insulin delivery device, and wherein receiving the information comprises:

receiving the information from an NFC receiver coupled to the insulin delivery device and configured to receive the information from the NFC device.

14. The method of claim 9, wherein obtaining the target glucose concentration comprises obtaining the target glucose concentration based on a user input.

15. The method of claim 9, wherein the controller has access to patient-specific information, and wherein obtaining the target glucose concentration comprises determining the target glucose concentration based on the patient-specific information.

16. A system comprising:

a flexible substrate configured to be mounted to a skin surface;

a sensor probe having a first end attached to the flexible substrate and a second end configured to extend beneath the skin surface to contact interstitial fluid;

a sensor configured to measure a physiological property, wherein the sensor is disposed at the second end of the sensor probe, and wherein the physiological property is related to glucose in the interstitial fluid; and

a near field communication (NFC) device mounted to the flexible substrate and electrically coupled to the sensor, wherein the NFC device is configured to receive from the sensor one or more sensor measurements indicative of the physiological property, and wherein the NFC device is configured to detect a controller and provide information related to the one or more sensor measurements to the controller in response to detecting the controller.