Drive control mechanisms and automatic injectors for injectable cartridges

• US 10,046,115 B2
• Filed: 12/16/2014
• Issued: 08/14/2018
• Est. Priority Date: 07/05/2012
• Status: Active Grant

• Current Assignee: UNL Holdings, LLC
• Original Assignee: UNL Holdings, LLC
• Inventors: Bokelman, Kevin, Wohlhieter, George M., McGee, Thomas F., Marlin, Arthur G., Hurowitz, Stefanie A., Jansen, David R., Ni Chathail, Ellen
• Primary Examiner(s): BOUCHELLE, LAURA A
• Application Number:
  US14/572,161
• Publication Number:
  US 20150174326A1
• Time in Patent Office: 1,337 Days
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2414 from the side
• CPC Class Codes: A61M 2005/31588 electrically driven
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding
• CPC Class Codes: A61M 5/31515 Connection of piston with piston rod
• CPC Class Codes: A61M 5/31581 performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001

Abstract

An automatic injector includes a housing having a guide, a drive control mechanism, a transmission assembly, a motor, and an energy source. The housing may further include a cartridge cover. A drive control mechanism includes a drive screw, a cartridge carrier, a plunger carrier, and one or more control transfer instruments, such as a puck or cylinder. The drive screw interfaces and connects with the plunger carrier. The automatic injector is configured to accept a variety of syringes as cartridges for drug delivery. The cartridges may be ejected from the injector and safely disposed after use, making the injector a reusable automatic injector. The reusable automatic injector may further include one or more sensors, such as a cartridge sensor and a patient sensor. The novel incorporation of the drive control mechanisms into the automatic injectors of the present invention enables a single motor and transmission assembly to drive the function of multiple components, which may include the steps of: preparation and alignment of a cartridge for injection, removal of a safety cap or needle shield, needle injection, drug dose delivery, and syringe and/or needle retraction. Methods of manufacture and methods of use are also disclosed.

Claims

1. An automatic injector comprising a distal end and a proximal end, and adapted to receive a cartridge including a barrel, a needle, and a plunger assembly including a plunger seal, the cartridge defining a longitudinal axis, the injector comprising:

a housing,

a cartridge carrier adapted to receive at least a portion of the cartridge, the cartridge carrier being disposed for movement relative to the housing in a direction parallel to the longitudinal axis of the cartridge,

a plunger carrier disposed for movement relative to the cartridge carrier, the plunger carrier including an elongated plunger rod being disposed to confront at least a portion of the plunger assembly and impart axial movement to the plunger seal,

an elongated drive device coupled to the plunger carrier, the elongated drive device being disposed to provide movement of the plunger rod relative to the cartridge carrier in a direction parallel to the longitudinal axis of the cartridge toward the distal end to impart axial movement to the plunger seal, and

a single drive mechanism disposed to provide movement of the plunger rod and the cartridge carrier to advance the cartridge in the direction parallel to the longitudinal axis of the cartridge toward the distal end.

2. The automatic injector of claim 1 wherein the plunger rod includes an interface feature that directly confronts the plunger seal.

3. The automatic injector of claim 2 wherein the plunger rod is at least partially disposed within the barrel during movement of the plunger rod in the direction parallel to the longitudinal axis of the cartridge during axial movement of the plunger seal.

4. The automatic injector of claim 1 wherein the plunger rod is at least partially supported for movement in the direction parallel to the longitudinal axis of the cartridge by a plunger nut having an aperture, the plunger rod being disposed for axial movement through the aperture of the plunger nut.

5. The automatic injector of claim 4 wherein the plunger rod includes an externally threaded portion and at least a portion of the aperture of the plunger nut includes an internal thread engagable with the externally threaded portion of the plunger rod.

6. The automatic injector of claim 5 wherein the plunger rod is disposed to rotate when the externally threaded portion engages the internal thread.

7. The automatic injector of claim 6 wherein the plunger rod includes an interface feature that directly confronts the plunger seal, and rotation of the plunger rod in the plunger nut causes the interface feature to rotate into the plunger seal.

8. The automatic injector of claim 7 wherein axial movement of the plunger rod in a proximal direction causes the plunger rod to rotate in an opposite direction when the externally threaded portion engages the internal thread.

9. The automatic injector of claim 1 further including a motor, and a transmission assembly coupling the motor to the elongated drive device.

10. The automatic injector of claim 1 further including at least one transfer instrument disposed to selectively couple the cartridge carrier to the plunger carrier for movement therewith, and wherein at least one of the plunger carrier and the cartridge carrier includes an opening that selectively receives the at least one transfer instrument to removably couple the cartridge carrier to the plunger carrier.

11. The automatic injector of claim 10 wherein the at least one transfer instrument is disposed within the openings in both the plunger carrier and the cartridge carrier to couple the plunger carrier and the cartridge carrier together.

12. The automatic injector of claim 1 further including at least one transfer instrument disposed to selectively couple the cartridge carrier to the plunger rod for movement therewith, and wherein the transfer instrument is disposed for movement between a first position wherein the transfer instrument engages only one of the either the cartridge carrier or the plunger carrier, and a second position wherein the transfer instrument engages both of the cartridge carrier and the plunger carrier to couple the cartridge carrier and the plunger carrier together for contemporaneous movement.

13. The automatic injector of claim 9 wherein the elongated drive device includes a rack coupled to the plunger carrier, and the transmission assembly includes a pinion gear disposed to engage and impart motion to the rack.

14. The automatic injector of claim 1 wherein the elongated drive device includes a threaded drive screw mounted for rotation by the motor, and the plunger carrier includes a threaded surface disposed to engage the drive screw.

15. The automatic injector of claim 14 further comprising a gear train including at least one gear disposed to transmit rotary motion from the motor to the drive screw.

16. The automatic injector of claim 1 further including an energy source coupled to the motor.

17. The automatic injector of claim 1 further including a user interface whereby a user may initiate operation of the automatic injector.

18. The automatic injector of claim 1 further including a cartridge ejector.

19. The automatic injector of claim 1 including at least one sensor.

20. A method of operating an automatic injector having a distal end and a proximal end to inject a fluid from a cartridge including a barrel with a needle end and a plunger seal disposed at least partially within the barrel, the method comprising

disposing the cartridge in the automatic injector with at least a portion of the barrel disposed within a cartridge carrier, and the plunger seal disposed for confrontation with a distal end of a plunger rod,

utilizing a single drive mechanism to move the plunger rod and the cartridge carrier to advance the cartridge in an axial direction toward the distal end,

decoupling the cartridge carrier from the plunger rod,

utilizing the drive mechanism to move the plunger rod in the axial direction toward the distal end to dispense the fluid, and

retracting the plunger rod in an axial direction toward the proximal end.