Process and device for delivery of fluid by chemical reaction

• US 10,046,116 B2
• Filed: 04/06/2016
• Issued: 08/14/2018
• Est. Priority Date: 10/12/2012
• Status: Active Grant

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Bennison, Corrie, Muenzer, Christopher H., Blum, Timothy M., McKenzie, Christopher P., Madland, Steven M., Ellis, Jeffrey L., Heintz, Amy M., Kaseman, Brian J.
• Primary Examiner(s): Buechner, Patrick M
• Assistant Examiner(s): Zadeh, Bob
• Application Number:
  US15/091,863
• Publication Number:
  US 20160213847A1
• Time in Patent Office: 860 Days
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/2026 Semi-automatic, e.g. user activated piston is assisted by additional source of energy
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: B65D 83/14 for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
• CPC Class Codes: B65D 83/60 Contents and propellant separated
• CPC Class Codes: B65D 83/64 by piston
• CPC Class Codes: B65D 83/643 the propellant being generated by a chemical or electrochemical reaction for pressure gas in portable fire extinguishers A62C13/02

Abstract

Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. An exemplary device may include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a one-way valve between the upper chamber and the lower chamber.

Claims

1. A device for delivering a fluid by chemical reaction, comprising:

a reagent chamber containing at least one of a solvent and a reagent and having a plunger at an upper end and a one-way valve at a lower end, the one-way valve permitting exit of the at least one of the solvent and the reagent from the reagent chamber;

a reaction chamber having the one-way valve at an upper end and a piston at a lower end; and

a fluid chamber having the piston at an upper end, wherein the piston moves in response to pressure generated in the reaction chamber such that the volume of the reaction chamber increases and the volume of the fluid chamber decreases;

wherein the reaction chamber contains at least one of a dry powder reagent and a release agent.

2. The device of claim 1, wherein the dry powder reagent is citrate and the release agent is sodium chloride.

3. The device of claim 1, wherein a needle is fluidly connected to an outlet of the fluid chamber;

and wherein the reaction chamber is located on top of the fluid chamber.

4. The device of claim 1, wherein the reagent chamber contains a first reagent and the reaction chamber contains a second reagent, and a movement of the plunger towards the one-way valve causes a mixing of the first reagent and the second reagent to initiate a gas-generating chemical reaction in the reaction chamber.

5. A device for delivering a fluid by chemical reaction, comprising:

an upper chamber containing at least one of a solvent and a reagent and having a stationary one-way valve at a lower end, the one-way valve permitting exit of the at least one of the solvent and the reagent from the upper chamber;

a plunger configured to travel through only the upper chamber;

a lower chamber having the stationary one-way valve at an upper end and a piston at a lower end, the lower chamber containing at least one reagent; and

a fluid chamber having the piston at an upper end;

wherein a movement of the plunger towards the one-way valve causes the at least one of the solvent and the reagent to exit the upper chamber to initiate a gas-generating chemical reaction in the lower chamber, and the piston moves in response to pressure generated in the lower chamber such that the volume of the lower chamber increases and the volume of the fluid chamber decreases.

6. The device of claim 5, wherein the fluid chamber contains a high-viscosity fluid having a viscosity of at least 40 centipoise.

7. The device of claim 5, wherein the upper chamber contains only the solvent and the lower chamber contains at least two reagents.

8. The device of claim 5, wherein the plunger includes a thumbrest and a pressure lock that cooperates with the upper chamber to lock the plunger in place after being depressed.

9. The device of claim 8, wherein the pressure lock is proximate the thumbrest and cooperates with an upper surface of the upper chamber.

10. The device of claim 5, wherein the lower chamber is defined by the one-way valve, a continuous sidewall, and the piston, the one-way valve and the sidewall being fixed relative to each other such that the volume of the lower chamber changes only through movement of the piston.

11. The device of claim 5, wherein the upper chamber, the lower chamber, and the fluid chamber are cylindrical and are coaxial.

12. The device of claim 5, wherein the upper chamber, the lower chamber, and the fluid chamber are separate pieces that are joined together to make the device.

13. The device of claim 5, wherein the upper chamber contains a first reagent and the lower chamber contains a second reagent, and a movement of the plunger towards the one-way valve causes a mixing of the first reagent and the second reagent to initiate a gas-generating chemical reaction in the lower chamber.