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Amyloid-beta binding proteins

  • US 10,047,121 B2
  • Filed: 06/22/2015
  • Issued: 08/14/2018
  • Est. Priority Date: 08/14/2010
  • Status: Active Grant
First Claim
Patent Images

1. An anti-Aβ

  • (20-42) globulomer antibody that comprises a heavy chain variable region and a light chain variable region, whereina) the heavy chain variable region comprises complementary determining region (CDR) H1, CDRH2, and CDRH3 of SEQ ID NO;

    17, SEQ ID NO;

    18, and SEQ ID NO;

    19, respectively, and the light chain variable region comprises CDRL1, CDRL2, and CDRL3 of SEQ ID NO;

    20, SEQ ID NO;

    21, and SEQ ID NO;

    22, respectively;

    b) the heavy chain variable region comprises CDRH1,CDRH2, and CDRH3 of SEQ ID NO;

    33, SEQ ID NO;

    34, and SEQ ID NO;

    35, respectively, and the light chain variable region comprises CDRL1, CDRL2, and CDRL3 of SEQ ID NO;

    36, SEQ ID NO;

    37, and SEQ ID NO;

    38, respectively;

    c) the heavy chain variable region is at least 90% identical to SEQ ID NO;

    1, 3, 4, 6, 7, 8, 9, 10, 11, 12, or 13, and the light chain variable region is at least 90% identical to SEQ ID NO;

    2, 5, 14, 15, or 16;

    ord) the heavy chain variable region is at least 90% identical to SEQ ID NO;

    25, 27, 29, or 30, and the light chain variable region is at least 96% identical to SEQ ID NO;

    26, 28, 31, or 32.

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