Bioproduction of chemicals
First Claim
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1. A genetically modified E. coli capable of producing a chemical product of interest, wherein the genetic modification includes introduction of heterologous nucleic acid sequences coding for:
- an acetyl-CoA carboxylase; and
one or more polypeptides selected from the group consisting of BicA from Synechococcus species, ychM gene product of E. coli, and yidE gene product of E. coli to facilitate importation of bicarbonate from an extracellular media to within the E. coli.
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Abstract
The present invention provides various combinations of genetic modifications to a transformed host cell that provide increase conversion of carbon to a chemical product. The present invention also provides methods of fermentation and methods of making various chemical products.
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Citations
2 Claims
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1. A genetically modified E. coli capable of producing a chemical product of interest, wherein the genetic modification includes introduction of heterologous nucleic acid sequences coding for:
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an acetyl-CoA carboxylase; and one or more polypeptides selected from the group consisting of BicA from Synechococcus species, ychM gene product of E. coli, and yidE gene product of E. coli to facilitate importation of bicarbonate from an extracellular media to within the E. coli. - View Dependent Claims (2)
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Specification