Detection of nucleic acids from multiple types of human papillomavirus
First Claim
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1. A detection probe oligomer for selectively detecting HPV types in group C1 in the presence of HPV types from one or more of groups A1, A2, B, C2, and D, wherein the detection probe oligomer comprises:
- (i) a target-specific sequence consisting of a nucleotide sequence selected from the group consisting of SEQ ID NOs;
13, 46, 45, complements thereof, and RNA equivalents thereof; and
(ii) a detectable label.
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Abstract
Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.
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21 Claims
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1. A detection probe oligomer for selectively detecting HPV types in group C1 in the presence of HPV types from one or more of groups A1, A2, B, C2, and D, wherein the detection probe oligomer comprises:
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(i) a target-specific sequence consisting of a nucleotide sequence selected from the group consisting of SEQ ID NOs;
13, 46, 45, complements thereof, and RNA equivalents thereof; and(ii) a detectable label. - View Dependent Claims (2, 3, 4, 20, 21)
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5. A method of determining the presence or absence of a human papillomavirus (HPV) nucleic acid type in group C1 in a sample, comprising the steps of:
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(a) contacting a sample with a detection probe oligomer comprising; (i) a target-specific sequence consisting of a nucleotide sequence selected from the group consisting of SEQ ID NOs;
13, 46, 45, complements thereof, and RNA equivalents thereof; and(ii) a detectable label; and (b) performing a detection reaction to detect a signal from the detectable label, wherein the signal indicates the presence of a human papillomavirus (HPV) nucleic acid type in group C1 in the sample. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification