System and method for motion-robust 3D magnetic resonance imaging of vessel walls

• US 10,052,033 B2
• Filed: 02/08/2016
• Issued: 08/21/2018
• Est. Priority Date: 03/12/2015
• Status: Active Grant

• Current Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System), Siemens Healthineers AG (Siemens AG)
• Original Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System), Siemens Healthcare GMBH (Siemens AG)
• Inventors: Bi, Xiaoming, Natsuaki, Yutaka, Fan, Zhaoyang, Li, Debiao, Laub, Gerhard
• Primary Examiner(s): BONNETTE, RODNEY ANDREW
• Application Number:
  US15/017,788
• Publication Number:
  US 20160266223A1
• Time in Patent Office: 925 Days
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: G01R 33/4826 in three dimensions
• CPC Class Codes: G01R 33/5607 by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

A magnetic resonance method and system are provided for providing improved 3D imaging of blood vessels and the like, which provides suppression of both blood and fat signals and is insensitive to subject motion, thereby facilitating improved visualization of vessel walls. The image data pulse sequence includes a plurality of pulse series, where each series includes a dark-blood sequence, a fat-suppression sequence, and a data readout sequence. Each data readout sequence samples a particular radial direction within each partition (Kz value) that passes through the Kz axis, and different radial orientations are sampled in subsequent series to provide a stack-of-stars sampling scheme.

Claims

1. A method for 3D imaging of blood vessels in a magnetic resonance (MR) system, comprising the steps of:

(a) generating a 3D image data set from a volume of a subject to be imaged using an imaging pulse sequence, wherein;

(i) the imaging pulse sequence comprises a plurality of imaging series;

(ii) each imaging series comprises a dark-blood sequence, a fat-suppression sequence, and a data readout sequence that follows both the dark-blood sequence and the fat-suppression sequence;

(iii) each data readout sequence samples data along a plurality of lines in k-space, wherein each line of the plurality of lines has a common radial direction in the Kx-Ky plane and a different Kz value, and passes through the Kz axis; and

(iv) data readout sequences corresponding to different series of the imaging pulse sequence sample lines in k-space having different radial directions in the Kx-Ky plane, and

(b) generating an image of at least a portion of the volume based at least in part on the 3D image data set.

2. The method of claim 1, wherein the dark-blood sequence precedes the fat-suppression sequence in each imaging series.

3. The method of claim 1, wherein the fat-suppression sequence precedes the dark-blood sequence in each imaging series.

4. The method of claim 1, wherein the dark-blood sequence is a flow-sensitive dephasing sequence.

5. The method of claim 1, wherein the dark-blood sequence is a delay alternating with nutation for tailored excitation (DANTE) sequence.

6. The method of claim 1, wherein each data readout sequence samples data along a further plurality of lines in k-space, wherein each line of the further plurality of lines has a second common radial direction in the Kx-Ky plane and a different Kz value, and passes through the Kz axis.

7. The method of claim 1, wherein the data readout sequences of the imaging pulse sequence sample lines in k-space having different radial directions in a sequential radial order.

8. The method of claim 1, wherein the data readout sequences of the imaging pulse sequence sample lines in k-space having different radial directions in an interleaved radial order.

9. The method of claim 1, wherein the plurality of radial lines sampled within each data readout sequence are sampled in an order of increasing distance from Kz=0 in k-space.

10. The method of claim 1, wherein the data readout sequences are spoiled gradient-echo readout sequences.

11. A magnetic resonance (MR) system for 3D imaging of blood vessels in a magnetic resonance (MR) system, comprising:

a radio frequency (RF) signal generator and a magnetic field gradient generator which are together configured to provide a an imaging pulse sequence comprising a plurality of RF pulse sequences and magnetic field gradient sequences for acquisition of 3D image data; and

an image processing unit configured to generate MR images of a volume of interest based on the 3D image data,

wherein;

the imaging pulse sequence comprises a plurality of imaging series;

each imaging series comprises a dark-blood sequence, a fat-suppression sequence, and a data readout sequence that follows both the dark-blood sequence and the fat-suppression sequence;

each data readout sequence samples data along a plurality of lines in k-space, wherein each line of the plurality of lines has a common radial direction in the Kx-Ky plane and a different Kz value, and passes through the Kz axis; and

data readout sequences corresponding to different series of the imaging pulse sequence sample lines in k-space having different radial directions in the Kx-Ky plane.

12. The system of claim 11, wherein the dark-blood sequence precedes the fat-suppression sequence in each imaging series.

13. The system of claim 11, wherein the fat-suppression sequence precedes the dark-blood sequence in each imaging series.

14. The system of claim 11, wherein the dark-blood sequence is a flow-sensitive dephasing sequence.

15. The system of claim 11, wherein the dark-blood sequence is a delay alternating with nutation for tailored excitation (DANTE) sequence.

16. The system of claim 11, wherein each data readout sequence samples data along a further plurality of lines in k-space, wherein each line of the further plurality of lines has a second common radial direction in the Kx-Ky plane and a different Kz value, and passes through the Kz axis.

17. The system of claim 11, wherein the data readout sequences of the imaging pulse sequence sample lines in k-space having different radial directions in a sequential radial order.

18. The system of claim 11, wherein the data readout sequences of the imaging pulse sequence sample lines in k-space having different radial directions in an interleaved radial order.

19. The system of claim 11, wherein the plurality of radial lines sampled within each data readout sequence are sampled in an order of increasing distance from Kz=0 in k-space.

20. The system of claim 11, wherein the data readout sequences are spoiled gradient-echo readout sequences.