Silicone based membranes for use in implantable glucose sensors

• US 10,052,051 B2
• Filed: 10/27/2017
• Issued: 08/21/2018
• Est. Priority Date: 05/22/2002
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Boock, Robert J., Swinney, Monica Rixman
• Primary Examiner(s): Jang, Christian
• Application Number:
  US15/796,163
• Publication Number:
  US 20180042533A1
• Time in Patent Office: 298 Days
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: C08G 77/12 containing silicon bound to hydrogen C08G77/045 takes precedence
• CPC Class Codes: C08G 77/20 containing silicon bound to unsaturated aliphatic groups C08G77/045 takes precedence
• CPC Class Codes: C08G 77/46 containing polyether sequences
• CPC Class Codes: C08L 2666/14 Macromolecular compounds according to C08L59/00 - C08L87/00; Derivatives thereof
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

Claims

1. An implantable continuous analyte sensor for measuring an analyte concentration, comprising:

a working electrode configured to generate a signal indicative of an analyte concentration;

a membrane disposed over the working electrode, the membrane comprising;

a first domain configured to control a flux of an analyte therethrough, wherein the first domain comprises a blend comprising a first polymer and second polymer, wherein the first polymer is a polymer selected from the group consisting of polyurethane, polyurea, polyurethaneurea, and a silicone-containing polymer, wherein the second polymer is a hydrophilic comb-copolymer; and

a second domain comprising an enzyme configured to react with an analyte, wherein at least a portion of the second domain is disposed between the first domain and the working electrode; and

sensor electronics operatively connected to the working electrode, wherein the sensor electronics are configured to process the generated signal to produce a glucose value.

2. The implantable continuous analyte sensor of claim 1, wherein the first polymer is a silicone-containing polyurethane.

3. The implantable continuous analyte sensor of claim 1, wherein the analyte is glucose.

4. The implantable continuous analyte sensor of claim 1, wherein the sensor is configured to be transcutaneously implanted.

5. The implantable continuous analyte sensor of claim 1, wherein the second polymer comprises a poly(ethylene oxide) (PEO) segment.

6. The implantable continuous analyte sensor of claim 1, wherein the second polymer comprises a poly(propylene oxide) (PPO) segment.

7. The implantable continuous analyte sensor of claim 1, wherein the second polymer has a molecular weight from 1,000 g/mol to 15,000 g/mol.

8. The implantable continuous analyte sensor of claim 1, wherein the second polymer comprises a hydrophilic domain and a hydrophobic domain, wherein the hydrophobic domain has a molecular weight from 500 g/mol to 8,000 g/mol.