Apparatus and methods for accessing the lymphatic system

• US 10,052,059 B2
• Filed: 03/15/2014
• Issued: 08/21/2018
• Est. Priority Date: 05/03/2011
• Status: Active Grant

• Current Assignee: LXS, LLC
• Original Assignee: LXS, LLC
• Inventors: Callaghan, Matthew J., Leeflang, Stephen A., Eversull, Christian S.
• Primary Examiner(s): Gilbert, Andrew
• Assistant Examiner(s): Darb, Hamza
• Application Number:
  US14/214,882
• Publication Number:
  US 20140303461A1
• Time in Patent Office: 1,620 Days
• CPC Class Codes: A61B 5/41 Detecting, measuring or recording for evaluating the immune or lymphatic systems
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621
• CPC Class Codes: A61M 2202/0405 Lymph
• CPC Class Codes: A61M 25/04 in the body, e.g. expansible A61M25/10, A61M16/0488 take precedence

Abstract

Systems and methods are provided for performing a medical procedure within a patient'"'"'s body that involves a thoracic duct including an ostium communicating with the patient'"'"'s venous system. A distal end of a catheter is introduced through the patient'"'"'s venous system into a body lumen adjacent the ostium of the thoracic duct. An expandable member on the distal end of the tubular member may be expanded adjacent the ostium, e.g., within the body lumen or the thoracic duct itself, and used to isolate the thoracic duct from the body lumen, whereupon a medical procedure may be performed via the thoracic duct. For example, lymphatic fluid may be removed from the thoracic duct through a lumen of the tubular member and/or one or more agents may be introduced into the thoracic duct through the tubular member.

Claims

1. A method for treating a body via a thoracic duct of the body, comprising:

providing a tubular member comprising a proximal end, a distal end sized for introduction into the body, and an expandable member on the distal end;

introducing the distal end of the tubular member into a body lumen of the body via a percutaneous access site with the expandable member in a contracted condition;

advancing the tubular member until the distal end is disposed within a junction of a left internal jugular vein and a left subclavian vein of the body;

manipulating the tubular member to direct the distal end into the thoracic duct;

expanding the expandable member on the distal end to isolate the thoracic duct from the left internal jugular vein and left subclavian vein;

removing a lymphatic fluid from the thoracic duct through the tubular member to a location exterior to the body;

treating the removed lymphatic fluid outside the body; and

returning at least a portion of the removed lymphatic fluid back into the body via the tubular member.

2. The method of claim 1, wherein the at least a portion of the removed lymphatic fluid is returned into the thoracic duct through the tubular member.

3. The method of claim 1, wherein the at least a portion of the removed lymphatic fluid is returned to treat sepsis within the body, and wherein treating the removed lymphatic fluid comprises one of:

a) performing leukofiltration of the removed lymphatic fluid before returning the at least a portion of the removed lymphatic fluid to the body to decrease immune response by the body;

b) filtering at least one of antibodies, interleukin, and non-cellular mediators before returning the at least a portion of the removed lymphatic fluid to the body to decrease t-cell activation by the body;

or

c) performing dialysis on the removed lymphatic fluid to remove at least one of toxins and non-cellular mediators before returning the at least a portion of the removed lymphatic fluid to the body.

4. The method of claim 1, wherein the at least a portion of the removed lymphatic fluid is returned to treat HIV or other viral infection within the body, and wherein treating the removed lymphatic fluid comprises at least one of:

a) separating t-cells from the removed lymphatic fluid and wherein the at least a portion of the removed lymphatic fluid returned to the body comprises the separated t-cells; and

a) separating protein from the removed lymphatic fluid and wherein the at least a portion of the removed lymphatic fluid returned to the body comprises the separated protein.

5. The method of claim 1, wherein the at least a portion of the removed lymphatic fluid is returned to treat HIV or other viral infection within the body, and wherein treating the removed lymphatic fluid comprises:

analyzing the removed lymphatic fluid to detect latently infected cell populations of the body.

6. The method of claim 5, wherein the removed lymphatic fluid is returned to the body to push the body towards a virus-free equilibrium or restore natural immune function after suppression.

7. The method of claim 1, wherein the at least a portion of the removed lymphatic fluid is returned to treat HIV or other viral infection within the body, wherein treating the removed lymphatic fluid to the body comprises adding one or more compounds to the removed lymphatic fluid returning at least a portion of the removed lymphatic fluid back into the body, and wherein returning the at least a portion of the removed lymphatic fluid to the body comprises infusing the at least a portion of the removed lymphatic fluid with the one or more added compounds to push the body towards a virus-free equilibrium or restore natural immune function after suppression.

8. The method of claim 7, wherein the one or more compounds comprise at least one of osmotically active fluid, osmotically neutral fluid, and one or more drugs to activate a virus causing the viral infection.

9. The method of claim 1, wherein the lymphatic fluid is removed from the thoracic duct through a first lumen of the tubular and the at least a portion of the removed lymphatic fluid is returned back into the body via the first lumen.

10. A method for treating a body via a thoracic duct of the body, comprising:

providing a tubular member comprising a proximal end, a distal end sized for introduction into the body, and an expandable member on the distal end;

introducing the distal end of the tubular member into a body lumen of the body via a percutaneous access site with the expandable member in a contracted condition;

advancing the tubular member until the distal end is disposed within a junction of a left internal jugular vein and a left subclavian vein of the body;

manipulating the tubular member to direct the distal end into an outlet of the thoracic duct;

expanding the expandable member on the distal end within the thoracic duct beyond a terminal valve adjacent the outlet to isolate the thoracic duct from the left internal jugular vein and left subclavian vein;

removing a lymphatic fluid from the thoracic duct through the tubular member to a location exterior to the body; and

returning at least a portion of the removed lymphatic fluid back into the body retrograde into the thoracic duct via the tubular member.

11. The method of claim 10, wherein the lymphatic fluid is removed to reduce a volume of interstitial fluid within the body.

12. The method of claim 11, wherein the lymphatic fluid is removed to reduce a portal pressure within a portal vein of the body.

13. The method of claim 12, wherein the lymphatic fluid is removed to reduce portal pressure to treat esophageal varicies.

14. The method of claim 12, wherein the lymphatic fluid is removed to reduce portal pressure to treat ascites.

15. The method of claim 10, wherein the lymphatic fluid is removed to manage hepatorenal syndrome.

16. The method of claim 10, wherein removing lymphatic fluid from the thoracic duct comprises periodically or intermittently draining lymphatic fluid from the thoracic duct to titrate the lymphatic fluid to a desired level or amount.

17. The method of claim 16, wherein the lymphatic fluid is titrated to achieve a desired lymph parameter selected from one or more of flow rate within the thoracic duct, pressure within the thoracic duct, volume removed, and color of fluid within the thoracic duct.

18. The method of claim 16, wherein the lymphatic fluid is titrated to maintain a desired systemic parameter of the body selected from one or more of body weight, central venous pressure (CVP), oxygen saturation, and dyspnea of the body.

19. The method of claim 10, further comprising performing a surgical procedure on the body and wherein lymphatic fluid is removed from the thoracic duct for fluid management of the body during the procedure.

20. The method of claim 19, wherein the surgical procedure includes a bypass procedure.

21. The method of claim 19, wherein the lymphatic fluid is removed for fluid management of an anuria of the body during the procedure.

22. The method of claim 19, further comprising measuring pressure within the thoracic duct using the tubular member to monitor at least one of ventilation of the body and fluid status of the body, and wherein lymphatic fluid is removed from the thoracic duct based at least in part on the measured pressure.

23. The method of claim 10, wherein at least a portion of the removed lymphatic fluid is returned into the thoracic duct to diagnose chylothorax.

24. The method of claim 10, wherein the lymphatic fluid is removed from the thoracic duct through a first lumen of the tubular and the at least a portion of the removed lymphatic fluid is returned back into the body via the first lumen.