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System and method for fluorescence-based laser ablation

  • US 10,052,154 B2
  • Filed: 10/01/2014
  • Issued: 08/21/2018
  • Est. Priority Date: 10/01/2014
  • Status: Active Grant
First Claim
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1. An apparatus comprising:

  • an excitation light source configured to produce excitation light wherein the excitation light comprises light having a wavelength that corresponds to an excitation wavelength of a fluorophore, wherein the fluorophore is configured to emit emission light at an emission wavelength in response to receiving light at the excitation wavelength;

    an ablation light source configured to produce ablation light wherein the ablation light is configured to ablate tissue;

    a beam combiner optically coupled to the excitation light source and the ablation light source;

    a camera configured to detect the emission light emitted by the fluorophore; and

    a controller, wherein the controller comprises a computer programmed to carry out instructions, the instructions comprising;

    causing the excitation light source to produce excitation light;

    causing the camera to capture an image of at least a particular tissue location;

    determining a topographical map of at least the particular tissue location based on a location of the camera and an angle of the excitation light with respect to the particular tissue location from the plurality of tissue locations;

    determining a fluorescence condition based on the image indicating emission light at the emission wavelength at the particular tissue location; and

    responsive to the fluorescence condition, causing the ablation light source to produce ablation light.

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