Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
First Claim
1. A prosthetic heart valve device for treating a valve of a human heart having a native annulus and native leaflets, comprising:
- a valve support having an upstream region and a downstream region;
a prosthetic valve within the valve support; and
an anchoring member having a connection structure and a fixation portion, the connection structure being attached to the downstream region of the valve support and at least a portion of the connection structure extends laterally outward from the valve support in a deployed state, the fixation portion extending in an upstream direction from the connection structure and having an annular engagement surface configured to engage an inner surface of the native annulus;
wherein an upstream end of the valve support is longitudinally aligned with and spaced radially apart from the fixation portion; and
wherein the fixation portion is configured to deflect with respect to the connection structure inwardly toward the valve support in the deployed state when the annular engagement surface engages the inner surface of the native annulus.
2 Assignments
0 Petitions
Accused Products
Abstract
Devices and methods for implantation at a native mitral valve having a non-circular annulus and leaflets. One embodiment of the device includes a valve support having a first region configured to be attached to a prosthetic valve with a plurality of prosthetic leaflets and a second region. The device can further include an anchoring member having a longitudinal dimension and including a first portion configured to contact tissue at the non-circular annulus, a second portion configured to be attached to the valve support, and a lateral portion between the first portion and the second portion. The second portion of the anchoring member is attached to the second region of the valve support while in a low-profile configuration in which the anchoring member and the valve support are configured to pass through vasculature of a human. The lateral portion is transverse to the longitudinal dimension. The anchoring member and the valve support are configured to move from the low-profile configuration to an expanded configuration in which the first portion of the anchoring member at least partially adapts to the non-circular annulus of the native mitral valve and the first region of the valve support is spaced inwardly from the first portion of the anchoring member relative to the longitudinal dimension of the anchoring member such that a shape of the first region of the valve support is at least partially independent of a shape of the first portion of the anchoring member.
729 Citations
19 Claims
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1. A prosthetic heart valve device for treating a valve of a human heart having a native annulus and native leaflets, comprising:
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a valve support having an upstream region and a downstream region; a prosthetic valve within the valve support; and an anchoring member having a connection structure and a fixation portion, the connection structure being attached to the downstream region of the valve support and at least a portion of the connection structure extends laterally outward from the valve support in a deployed state, the fixation portion extending in an upstream direction from the connection structure and having an annular engagement surface configured to engage an inner surface of the native annulus; wherein an upstream end of the valve support is longitudinally aligned with and spaced radially apart from the fixation portion; and wherein the fixation portion is configured to deflect with respect to the connection structure inwardly toward the valve support in the deployed state when the annular engagement surface engages the inner surface of the native annulus. - View Dependent Claims (2, 3)
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4. A prosthetic heart valve device for treating a valve of a human heart having a native annulus and native leaflets, comprising:
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a valve support having an upstream region and a downstream region; a prosthetic valve within the valve support; and an anchoring member having a connection structure and a fixation portion, the connection structure being attached to the valve support and at least a portion of the connection structure extends laterally outward from the valve support in a deployed state, the fixation portion having an annular engagement surface configured to engage an inner surface of the native annulus; and wherein the fixation portion is configured to deflect with respect to the connection structure inwardly toward the valve support in the deployed state when the annular engagement surface engages the inner surface of the native annulus; wherein the upstream region of the valve support has an upstream end and the engagement surface has an upstream end, and the upstream end of the valve support and the upstream end of the engagement surface are at approximately the same elevation in the deployed state; wherein the outer annular frame is configured to exert a radially outward force against an inner surface of the native annulus that secures the device to the native annulus during ventricular systole without tethers. - View Dependent Claims (5, 6, 7, 8, 9, 10)
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11. A prosthetic heart valve device for treating a valve of a human heart having a native annulus and native leaflets, comprising:
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an inner frame with an upstream region and a downstream region relative to a direction of blood flow through the inner annular frame; a prosthetic valve within the inner frame; and an anchoring member having an outer frame including a downstream section, an upstream section, and an outwardly facing engagement surface configured to engage an inwardly facing surface of the native annulus in a deployed state; wherein the anchoring member is configured such that, when the engagement surface engages the inwardly facing surface of the native annulus in the deployed state, the downstream section of the outer frame is spaced radially outward from the downstream portion of the inner frame by a first distance and the upstream section of the outer frame is spaced radially apart from the upstream portion of inner frame by a second distance less than the first distance, and wherein, when the anchoring member is in the deployed state, the upstream section of the outer frame is at an elevation at least proximate to an elevation of an upstream end of inner frame. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. A prosthetic heart valve device for treating a valve of a human heart having a native annulus and native leaflets, comprising:
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a valve support having an upstream region and a downstream region, wherein the valve support is configured to retain a prosthetic valve; a connection structure attached to the downstream region of the valve support, wherein at least a portion of the connection structure extends laterally outward from the valve support in a deployed state; and a fixation portion having an annular engagement surface configured to engage an inner surface of the native annulus, wherein the fixation portion extends in an upstream direction from the connection structure and is configured to deflect with respect to the connection structure inwardly toward the valve support in the deployed state when the annular engagement surface engages the inner surface of the native annulus, and wherein the upstream end of the valve support is longitudinally aligned with and spaced radially apart from the fixation portion.
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Specification