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Lipid formulations for delivery of messenger RNA

  • US 10,052,284 B2
  • Filed: 03/06/2017
  • Issued: 08/21/2018
  • Est. Priority Date: 10/22/2013
  • Status: Active Grant
First Claim
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1. A method of treating cystic fibrosis comprisingadministering to subject in need of treatment a composition comprising an mRNA encoding a cystic fibrosis transmembrane conductance regulator (CFTR) protein encapsulated within a liposome such that the administering of the composition results in the expression of the CFTR protein encoded by the mRNA in one or more tissues affected by cystic fibrosis;

  • wherein the liposome comprises a cationic lipid of formula I-c;

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