Glutamate agents in the treatment of mental disorders

• US 10,052,318 B2
• Filed: 05/15/2014
• Issued: 08/21/2018
• Est. Priority Date: 04/05/2005
• Status: Active Grant

• Current Assignee: Yale University
• Original Assignee: Yale University
• Inventors: Coric, Vladimir, Krystal, John H., Sanacora, Gerard
• Primary Examiner(s): Pihonak, Sarah
• Application Number:
  US14/278,573
• Publication Number:
  US 20140249173A1
• Time in Patent Office: 1,559 Days
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/13 Amines A61K31/04 takes precedence
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/425 Thiazoles
• CPC Class Codes: A61K 31/428 condensed with carbocyclic rings
• CPC Class Codes: A61K 31/43 Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 31/545 Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins, cefaclor, or cephalexine
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: G02B 1/10 Optical coatings produced by application to, or surface treatment of, optical elements G02B1/08 takes precedence
• CPC Class Codes: G02B 5/281 designed for the infrared light
• CPC Class Codes: G02B 5/283 designed for the ultraviolet
• CPC Class Codes: G02B 5/285 comprising deposited thin solid films G02B5/281 - G02B5/289 take precedence; multilayered film filters for fibre optic multiplexing G02B6/29361
• CPC Class Codes: H01L 27/14621 Colour filter arrangements
• CPC Class Codes: H01L 27/14685 Process for coatings or optical elements

Abstract

Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.

Claims

1. A method of treating a mental disorder in an individual in need thereof comprising administering to said individual a pharmaceutical composition comprising an effective amount of riluzole alone for treating said mental disorder, wherein said mental disorder is social anxiety disorder or panic disorder.

2. The method according to claim 1 wherein said mental disorder is social anxiety disorder.

3. The method according to claim 1 wherein said mental disorder is panic disorder.

4. The method according to claim 1 wherein said composition is administered once daily.

5. The method according to claim 2 wherein said composition is administered once daily.

6. The method according to claim 3 wherein said composition is administered once daily.