Nitric oxide topical application apparatus and methods

• US 10,052,348 B2
• Filed: 01/25/2017
• Issued: 08/21/2018
• Est. Priority Date: 01/27/2016
• Status: Active Grant

• Current Assignee: SYK Technologies, LLC
• Original Assignee: SYK Technologies, LLC
• Inventors: Miller, C. Michael, Hill, Gordon K., Pate, A. John, Bell, David A.
• Primary Examiner(s): Sasan, Aradhana
• Application Number:
  US15/415,550
• Publication Number:
  US 20170209485A1
• Time in Patent Office: 573 Days
• Field of Search: None
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/122 Foams; Dry foams edible foams A61K9/0056
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders

Abstract

A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam. The resultant foams are combined to initiate the production of nitric oxide and the mixture of foams is applied topically to treat various skin disorders or wounds.

Claims

1. A method for treating skin disorders comprising:

providing a first solution comprising water, at least one nitrite reactant, and a cationic surfactant;

providing a second solution comprising water, at least one acidic reactant, and the cationic surfactant;

dispensing a portion of the first solution in a manner that produces a first foam;

dispensing a portion of the second solution in a manner that produces a second foam;

mixing the first foam and the second foam to produce a resultant foam;

applying the resultant foam to a portion of skin to be treated; and

allowing the resultant foam to collapse.

2. The method of claim 1, further comprising:

allowing the resultant foam to remain on the portion of skin for at least three minutes; and

removing any remaining resultant foam from the portion of skin.

3. The method of claim 1, wherein:

the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 1 g of the cationic surfactant; and

the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 6 g of citric acid, and 3 g of the cationic surfactant.

4. The method of claim 1, wherein:

the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 1 g of the cationic surfactant; and

the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 8 g of citric acid, and 3 g of the cationic surfactant.

5. The method of claim 1, wherein:

the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 2 g of the cationic surfactant; and

the second solution comprises approximately 100 mL of water, 10 g of citric acid, and 6 g of the cationic surfactant.

6. The method of claim 1, wherein:

the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 2 g of the cationic surfactant; and

the second solution comprises approximately 100 mL of water, 5 g of ascorbic acid, 8 g of citric acid, and 6 g of the cationic surfactant.

7. The method of claim 3, further comprising:

allowing the resultant foam to remain on the portion of skin for at least three minutes; and

removing any remaining resultant foam from the portion of skin.

8. The method of claim 7, wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 90% and 120% during the time the resultant foam remains on the portion of skin.

9. The method of claim 6, further comprising:

allowing the resultant foam to remain on the portion of skin for at least three minutes; and

removing any remaining resultant foam from the portion of skin.

10. The method of claim 7, wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.

11. A method for treating skin disorders comprising:

providing a first solution comprising approximately 100 mL of water, 10 g of a nitrite reactant, and 2 g of a cationic surfactant;

providing a second solution comprising approximately 100 mL of water, 10 g of an acidic reactant, and 6 g of the cationic surfactant;

dispensing a portion of the first solution in a manner that produces a first foam;

dispensing a portion of the second solution in a manner that produces a second foam;

mixing the first foam and the second foam to produce a resultant foam;

applying the resultant foam to a portion of skin to be treated; and

allowing the resultant foam to remain on the portion of skin for at least three minutes wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.

12. The method of claim 11, wherein the nitrite reactant is selected from the group consisting of sodium nitrite and potassium nitrite, and the acidic reactant is selected from the group consisting of citric acid, lactic acid, salicylic acid, phosphoric acid, and ascorbic acid.

13. The method of claim 11, wherein the first solution further comprises approximately 2 g of sodium bicarbonate.

14. The method of claim 11, wherein the first solution further comprises a salt buffer for regulating the reaction rate of nitric oxide production.

15. A method for topical application comprising:

providing a first solution comprising approximately 100 mL of water, 10 g of a nitrite reactant, and 2 g of a cationic surfactant;

providing a second solution comprising approximately 100 mL of water, 10 g of an acidic reactant, and 6 g of the cationic surfactant;

dispensing a portion of the first solution in a manner that produces a first foam;

dispensing a portion of the second solution in a manner that produces a second foam;

mixing the first foam and the second foam to produce a resultant foam, wherein the resultant foam produces nitric oxide;

applying the resultant foam to a portion of skin to be treated; and

allowing the resultant foam to collapse in response to contact with the portion of skin.

16. The method of claim 15, further comprising, allowing the resultant foam to remain on the portion of skin for at least three minutes.

17. The method of claim 16, wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.

18. The method of claim 15, wherein the first solution further comprises approximately 2 g of sodium bicarbonate.

19. The method of claim 15, wherein the first solution further comprises a salt buffer for regulating the reaction rate of nitric oxide production.