Method for preparing neutralized matrix of non-antigenic collagenous material
First Claim
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1. A method for preparing a neutralized matrix of non-antigenic collagenous material comprising:
- a) preparing an acidic solution of non-antigenic collagenous material, wherein a pH of said acidic solution is adjusted to a value ranging from about 2.0 to about 4.0,b) pouring said acidic solution of a) into a mold in order to form a layer,c) lyophilizing said layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material,d) sterilizing said acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material.
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Abstract
The present invention relates to a method for preparing a neutralized matrix of non-antigenic collagenous material comprising the steps of: —a) preparing an acidic solution of non-antigenic collagenous material, —b) pouring the solution of a) into a mold in order to form a layer, —c) lyophilizing the layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material, d) sterilizing the acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material. The invention also relates to the matrices obtained and to surgical implants comprising such matrices.
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18 Claims
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1. A method for preparing a neutralized matrix of non-antigenic collagenous material comprising:
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a) preparing an acidic solution of non-antigenic collagenous material, wherein a pH of said acidic solution is adjusted to a value ranging from about 2.0 to about 4.0, b) pouring said acidic solution of a) into a mold in order to form a layer, c) lyophilizing said layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material, d) sterilizing said acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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