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Method for preparing neutralized matrix of non-antigenic collagenous material

  • US 10,052,400 B2
  • Filed: 06/01/2015
  • Issued: 08/21/2018
  • Est. Priority Date: 05/30/2014
  • Status: Active Grant
First Claim
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1. A method for preparing a neutralized matrix of non-antigenic collagenous material comprising:

  • a) preparing an acidic solution of non-antigenic collagenous material, wherein a pH of said acidic solution is adjusted to a value ranging from about 2.0 to about 4.0,b) pouring said acidic solution of a) into a mold in order to form a layer,c) lyophilizing said layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material,d) sterilizing said acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material.

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