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Apparatus for extracorporeal treatment of blood and process of calculating set flow rates in a medical apparatus for delivery or collection of fluids

  • US 10,052,423 B2
  • Filed: 08/23/2012
  • Issued: 08/21/2018
  • Est. Priority Date: 08/30/2011
  • Status: Active Grant
First Claim
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1. An apparatus for extracorporeal treatment of blood comprising:

  • a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;

    a blood withdrawal line connected to an inlet of the primary chamber, and a blood return line connected to an outlet of the primary chamber said blood lines being configured for connection to a patient cardiovascular system;

    a blood pump configured to control the flow of blood through the blood lines;

    an effluent fluid line connected to an outlet of the secondary chamber;

    at least two further fluid lines selected in the group comprising;

    a pre-dilution infusion fluid line connected at one end thereof to the blood withdrawal line,a post-dilution infusion fluid line connected at one end thereof to the blood return line,a dialysis fluid line connected at one end thereof to the inlet of the secondary chamber,a pre-blood pump infusion fluid line connected at one end thereof to the blood withdrawal line in a region positioned in use upstream the blood pump,at least one solution pump configured to regulate the flow of fluid through said fluid lines; and

    a control unit comprising a memory and connected operably to the at least one solution pump, the control unit being configured to;

    enter a set value by an operator for at least a first fluid flow rate selected in the group including;

    a fluid flow rate (Qrep1) through the pre-dilution infusion fluid line,a fluid flow rate (Qrep2) through the post-dilution infusion fluid line,a fluid flow rate (Qpbp) through the pre-blood pump infusion fluid line,a fluid flow rate (Qdial) through the dialysis fluid line, anda fluid removal rate (Qpfr) from the patient,enter a set value by the operator for a prescribed dose (Dset) to be delivered,calculate set values of at least a second and a third of the fluid flow rates of said group of flow rates by applying said prescribed dose value (Dset) and the set value of the first fluid flow rate to a plurality of mathematical relations, wherein said plurality of mathematical relations stored in said memory comprise one or more of the following;

    a convection-diffusion relation, relating the total fluid flow rate through said infusion fluid lines (Qrep1+Qrep2+Qpbp) with the fluid flow rate through said dialysis fluid line (Qdial), ora pre-post relation, relating the fluid flow rates (Qrep1+Qpbp) through pre-dilution infusion fluid line and pre-blood pump infusion fluid line with the fluid flow rate through the post-dilution infusion fluid line (Qrep2), andwherein calculating the set values of the at least second and third of the fluid flow rates reduces a number of flow rate set values entered into the control unit by the operator.

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