Hemodynamically unstable ventricular arrhythmia detection

• US 10,052,494 B2
• Filed: 03/13/2015
• Issued: 08/21/2018
• Est. Priority Date: 12/23/2014
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sheldon, Todd J, Demmer, Wade M, Whitman, Teresa A
• Primary Examiner(s): MAHMOOD, NADIA AHMAD
• Application Number:
  US14/657,001
• Publication Number:
  US 20160175603A1
• Time in Patent Office: 1,257 Days
• Field of Search: 607 4- 6
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/6869 Heart
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

An implantable medical device system includes a pacemaker and an implantable cardioverter defibrillator (ICD). The pacemaker is configured to confirm a hemodynamically unstable rhythm based on an activity metric determined from an activity sensor signal after detecting a ventricular tachyarrhythmia and withhold anti-tachycardia pacing (ATP) pulses in response to confirming the hemodynamically unstable rhythm. The pacemaker may deliver ATP when a hemodynamically unstable rhythm is not confirmed based on the activity metric. The ICD is configured to detect the ATP and withhold a shock therapy in response to detecting the ATP in some examples.

Claims

1. An implantable medical device system, comprising:

an activity sensor configured to produce an activity sensor signal correlated to patient activity and comprising heart motion signals; and

a cardiac pacemaker comprising;

a first sensing module configured to receive a first cardiac electrical signal;

a pulse generator configured to generate and deliver pacing pulses to a patient'"'"'s heart via a pair of electrodes; and

a control module coupled to the first sensing module, the pulse generator and the activity sensor and configured to;

detect a ventricular tachyarrhythmia from the first cardiac electrical signal;

determine an activity metric from the activity sensor signal;

confirm the detected ventricular tachyarrhythmia as being a hemodynamically unstable rhythm based on the activity metric; and

control the pulse generator to withhold anti-tachycardia pacing (ATP) in response to confirming the hemodynamically unstable rhythm.

2. The system of claim 1, wherein the pacemaker control module is further configured to deliver the ATP by the pacemaker in response to not confirming the hemodynamically unstable rhythm based on the activity metric;

the system further comprising an implantable cardioverter defibrillator (ICD), the ICD comprising;

a sensing module configured to receive a second cardiac electrical signal;

a therapy delivery module configured to deliver a shock therapy via electrodes coupled to the ICD; and

a processor and control module configured to;

detect the ventricular tachyarrhythmia from the second cardiac electrical signal;

detect from the second cardiac electrical signal at least one ATP pulse delivered by the pacemaker; and

withhold a shock therapy response to detecting the at least one ATP pulse.

3. The system of claim 1, wherein the pacemaker control module is further configured to confirm the hemodynamically unstable rhythm by:

comparing the activity metric to a normal resting range of the activity metric corresponding to a resting state of the patient; and

confirming the hemodynamically unstable rhythm in response to the activity metric being less than the normal resting range.

4. The system of claim 1, wherein the pacemaker control module is further configured to:

establish a lower rate set point as a maximum value of the activity metric during a patient resting state;

establish an unstable rhythm threshold based on the lower rate set point;

wherein confirming the hemodynamically unstable rhythm comprises comparing the activity metric to the unstable rhythm threshold.

5. The system of claim 2, wherein:

the pacemaker control module is further configured to;

compare the activity metric to an unstable rhythm threshold that is less than an expected resting range of the activity metric;

confirm the detected ventricular tachyarrhythmia as a hemodynamically unstable rhythm in response to the activity metric being less than the unstable rhythm threshold;

withhold the ATP in response to confirming the hemodynamically unstable rhythm;

the ICD processor and control module is further configured to;

responsive to detecting the ventricular tachyarrhythmia, determine from the second cardiac electrical signal an absence of ATP pulses delivered by the pacemaker; and

control the therapy delivery module to deliver a shock therapy in response to determining the absence of ATP pulses.

6. The system of claim 5, wherein the ICD processor and control module is further configured to:

determine the absence of the ATP pulses by monitoring for at least one ATP pulse during a shock delay interval; and

control the therapy delivery module to deliver the shock therapy after expiration of the shock delay interval in response to determining the absence of the ATP pulses during the shock delay interval.

7. The system of claim 6, wherein the ICD processor and control module is configured to control the therapy delivery module to charge a high voltage capacitor during at least a portion of the shock delay interval.

8. The system of claim 2, wherein the ICD processor and control module is configured to control the therapy delivery module to charge a high voltage capacitor in response to detecting the at least one ATP pulse.

9. The system of claim 2, wherein the ICD processor and control module is further configured to:

delay the withheld shock therapy in response to sensing the at least one ATP pulse; and

control the therapy delivery module to deliver the delayed shock therapy in response to redetecting the ventricular tachyarrhythmia after detecting the at least one ATP pulse and no longer detecting ATP pulses.

10. The system of claim 1, wherein the pacemaker control module is configured to determine the activity metric by determining an activity count from an accelerometer signal.

11. The system of claim 1, wherein the pacemaker control module is configured to determine the activity metric by:

determining a plurality of activity metrics at an activity metric sampling interval;

identifying from the plurality of activity metrics at least one of a most recent activity metric prior to detecting the ventricular tachyarrhythmia and an earliest occurring activity metric after detecting the ventricular tachyarrhythmia.

12. The system of claim 1, wherein the pacemaker control module is further configured to:

determine a signal reliability metric from the activity sensor signal;

compare the signal reliability metric to signal reliability criteria; and

withhold the ATP if the signal reliability metric does not meet the signal reliability criteria.

13. The system of claim 12, wherein the pacemaker control module is further configured to:

determine the signal reliability metric by determining a plurality of activity metrics from the activity sensor signal during a time interval preceding the ventricular tachyarrhythmia detection; and

determine whether the signal reliability metric meets the signal reliability criteria by comparing a distribution of the plurality of activity metrics to an expected activity metric distribution.

14. The system of claim 12, wherein the pacemaker control module is further configured to:

determine the signal reliability metric by determining a rate of heart motion signals from the activity sensor signal during a time interval preceding the ventricular tachyarrhythmia detection;

determine a heart rate from the first cardiac electrical signal; and

determine that the signal reliability metric meets the signal reliability criteria by comparing the determined rate of heart motion signals to the heart rate.

15. The system of claim 1, wherein the activity sensor comprises an intracardiac accelerometer.

16. The system of claim 2, further comprising:

an extravascular electrical lead coupled to the ICD and carrying a plurality of electrodes; and

wherein the pacemaker is configured to be wholly implanted within a chamber of a patient'"'"'s heart and comprises a housing enclosing the activity sensor, the pacemaker sensing module, the pulse generator and the pacemaker control module.

17. A non-transitory, computer readable storage medium storing a set of instructions that, when executed by control circuitry of an implantable medical device system, cause the system to:

sense a first cardiac electrical signal by an electrical sensing module of a cardiac pacemaker;

detect, by the pacemaker, a ventricular tachyarrhythmia from the first cardiac electrical signal;

determine an activity metric from an activity sensor signal received by a control module of the pacemaker;

confirm a hemodynamically unstable rhythm based on the activity metric; and

withhold anti-tachycardia pacing (ATP) by the pacemaker in response to confirming the hemodynamically unstable rhythm.