System and method for estimating and manipulating estimated radiation dose
First Claim
1. A method, performed on a computer system, for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
- (a) receiving, at the computer system, the achievable dose distribution estimate;
(b) determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification;
(c) for each beam from among a plurality of beams;
(i) characterizing, by the computer system, the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and
(ii) identifying, by the computer system, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel;
(d) modifying, by the computer system, the intensity values of at least one of the dose-change beamlets; and
(e) updating, by the computer system, the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.
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Abstract
Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.
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Citations
20 Claims
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1. A method, performed on a computer system, for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
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(a) receiving, at the computer system, the achievable dose distribution estimate; (b) determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; (c) for each beam from among a plurality of beams; (i) characterizing, by the computer system, the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and (ii) identifying, by the computer system, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; (d) modifying, by the computer system, the intensity values of at least one of the dose-change beamlets; and (e) updating, by the computer system, the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method, performed on a computer system, for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
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(a) receiving, at the computer system, the achievable dose distribution estimate; (b) determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; (c) for each beam from among a plurality of beams; (i) characterizing, by the computer system, the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and (ii) identifying, by the computer system, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; (d) modifying, by the computer system, the intensity values of at least one of the dose-change beamlets; and (e) updating, by the computer system, the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets; wherein determining the dose modification voxel comprises;
receiving, as input, a requested modification to a dose quality metric; and
using the requested modification to the dose quality metric to determine the dose modification voxel; andwherein determining the magnitude of desired dose modification comprises using the requested modification to the dose quality metric to determine the magnitude of desired dose modification.
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15. A method, performed on a computer system, for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
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(a) receiving, at the computer system, the achievable dose distribution estimate; (b) determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; (c) for each beam from among a plurality of beams; (i) characterizing, by the computer system, the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and (ii) identifying, by the computer system, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; (d) modifying, by the computer system, the intensity values of at least one of the dose-change beamlets; and (e) updating, by the computer system, the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets; wherein determining the dose modification voxel comprises;
receiving, as input, a requested modification to a dose quality metric; and
using the requested modification to the dose quality metric to determine the dose modification voxel; andwherein the dose quality metric comprises a DVH curve and wherein using the requested modification to the dose quality metric to determine the dose modification voxel comprises; identifying a location of the requested modification on the DVH curve to have a dose value D selected; and identifying a voxel in the achievable dose distribution estimate having a dose value in a range D selected±
Δ
to be the dose modification voxel, where Δ
is a range parameter;wherein identifying the voxel in the achievable dose distribution estimate having the dose value in the range D selected±
Δ
to be the dose modification voxel comprises identifying a plurality of candidate dose modification voxels having dose values in the range D selected±
Δ
; andwherein the method further comprises selecting a plurality of the candidate dose modification voxels to be dose modification voxels and performing steps (c), (d), and (e) for each of the dose modification voxels.
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16. A method, performed on a computer system, for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
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(a) receiving, at the computer system, the achievable dose distribution estimate; (b) determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; (c) for each beam from among a plurality of beams; (i) characterizing, by the computer system, the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and (ii) identifying, by the computer system, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; (d) modifying, by the computer system, the intensity values of at least one of the dose-change beamlets; and (e) updating, by the computer system, the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets; wherein determining the dose modification voxel and the corresponding magnitude of desired dose modification comprises receiving, as input, direct indications of the dose modification voxel and the magnitude of the desired dose modification. - View Dependent Claims (17, 18, 19)
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20. A method performed on a computer system for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
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(a) receiving, at the computer system, the achievable dose distribution estimate; (b) determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; (c) for each beam from among a plurality of beams; (i) characterizing, by the computer system, the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and (ii) identifying, by the computer system, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; (d) modifying, by the computer system, the intensity values of at least one of the dose-change beamlets; (e) updating, by the computer system, the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets; and determining one or more secondary dose modification voxels and corresponding magnitudes of desired dose modification for the one or more secondary dose modification voxels and treating the secondary dose modification values as dose modification voxels when performing steps (c), (d), and (e).
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Specification