Apparatus and method for rapid chemical analysis using differential desorption
First Claim
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1. A system comprising:
- one or more fibers, where at least one fiber includes a sorbent coating to permit exposure of the sorbent coating to two or more independent target areas of ionizing species, where the sorbent coating extends a width on the at least one fiber or a diameter around the at least one fiber between;
a lower limit of approximately 0.05 mm; and
an upper limit of approximately 2 mm;
an ionization source adapted to direct one or more ionizing species at one of the two or more independent target areas of the at least one fiber thereby generating a plurality of sample ions from one of the two or more independent target areas; and
an analyzer, adapted to analyze the plurality of sample ions.
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Abstract
The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.
250 Citations
22 Claims
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1. A system comprising:
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one or more fibers, where at least one fiber includes a sorbent coating to permit exposure of the sorbent coating to two or more independent target areas of ionizing species, where the sorbent coating extends a width on the at least one fiber or a diameter around the at least one fiber between; a lower limit of approximately 0.05 mm; and an upper limit of approximately 2 mm; an ionization source adapted to direct one or more ionizing species at one of the two or more independent target areas of the at least one fiber thereby generating a plurality of sample ions from one of the two or more independent target areas; and an analyzer, adapted to analyze the plurality of sample ions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system comprising:
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one or more fibers, where at least one fiber includes a sorbent coating with length and one or both a width and a diameter to permit exposure of the sorbent coating to a first target area and a second target area, where ionizing species directed to the first target area do not overlap with ionizing species directed to the second target area, where the one or both the width and the diameter of the sorbent coating is between; a lower limit of approximately 0.05 mm, and an upper limit of approximately 2 mm; an ionization source adapted to direct one or more ionizing species at one or both the first target area and the second target area of the at least one fiber thereby generating a plurality of sample ions from one or both the first target area and the second target area; and an analyzer, adapted to analyze the plurality of sample ions. - View Dependent Claims (14, 15, 16)
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17. A system comprising:
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one or more fibers, where at least one fiber includes a sorbent coating with length and a width or diameter to permit exposure of the sorbent coating to two or more independent target areas of ionizing species; a first ionization source adapted to direct one or more ionizing species at one or more independent target areas of the at least one fiber thereby generating a first plurality of sample ions from the one or more independent target areas; a second ionization source adapted to direct one or more ionizing species at one or more independent target areas of the at least one fiber thereby generating a second plurality of sample ions from the one or more independent target areas, where one or both the first ionization source and the second ionization source are selected from the group consisting of DART, DESI, MALDI, UV laser, IR laser, atmospheric pressure chemical ionization, directed electrospray, electrospray, dielectric barrier discharge, and flowing after-glow plasma source; and an analyzer to analyze one or both the first plurality of sample ions and the second plurality of sample ions. - View Dependent Claims (18)
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19. A system comprising:
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one or more fibers, where at least one fiber includes a sorbent coating to permit exposure of the sorbent coating to a first target area and a second target area; a first ionization source adapted to direct a first ionizing species at the first target area thereby generating a first plurality of sample ions; a second ionization source, where the second ionization source directs a second ionizing species at the second target area thereby generating a second plurality of sample ions; and an analyzer, adapted to analyze one or both the first plurality of sample ions and the second plurality of sample ions. - View Dependent Claims (20)
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21. A system comprising:
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one or more fibers, where at least one fiber includes a sorbent coating with length and one or both a width and a diameter to permit exposure of the sorbent coating to a first target area and a second target area, where ionizing species directed to the first target area do not overlap with ionizing species directed to the second target area, where the length of the sorbent coating is between; a lower limit of approximately 4 mm, and an upper limit of approximately 150 mm; an ionization source adapted to direct one or more ionizing species at one or both the first target area and the second target area of the at least one fiber thereby generating a plurality of sample ions from one or both the first target area and the second target area; and an analyzer, adapted to analyze the plurality of sample ions. - View Dependent Claims (22)
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Specification