Simultaneous imaging, monitoring, and therapy

• US 10,058,284 B2
• Filed: 12/19/2013
• Issued: 08/28/2018
• Est. Priority Date: 12/21/2012
• Status: Active Grant

• Current Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Original Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Inventors: Hoseit, Paul, Huennekens, Scott
• Primary Examiner(s): Porter, Jr., Allen
• Application Number:
  US14/134,184
• Publication Number:
  US 20140180034A1
• Time in Patent Office: 1,713 Days
• Field of Search: 600437, 600439, 600443, 600459
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00422 Angioplasty
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/00863 Fluid flow
• CPC Class Codes: A61B 2218/007 Aspiration
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6847 mounted on an invasive device
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: A61N 2007/0043 intra-cavitary
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Using the disclosed intravascular devices it is possible to image tissues, deliver therapy, and evaluate the tissue after the therapy is delivered. One embodiment is a catheter configured to provide ultrasound imaging, drug delivery, and Doppler flow analysis. The devices can use ultrasound imaging as well as optical coherence tomography (OCT).

Claims

1. An intravascular device comprising:

a ring-shaped transducer array located at a distal end of the intravascular device, wherein the ring-shaped transducer array is configured to image a tissue;

a therapy lumen located at the distal end of the intravascular device, wherein the therapy lumen passes through the ring-shaped transducer array and terminates in a therapy port that is configured to deliver a therapy to a tissue; and

a sensor located distal to the therapy port at a distal-most tip of the distal end of the intravascular device, wherein the sensor is separate from the ring-shaped transducer array and is configured to measure blood flow in an environment associated with the tissue.

2. The device of claim 1, wherein the therapy lumen passing through the ring-shaped transducer array is a drug delivery lumen configured to deliver a drug through the therapy lumen.

3. The device of claim 1, wherein the therapy lumen passing through the ring-shaped transducer array is an aspiration lumen configured to aspirate tissue through the therapy lumen.

4. The device of claim 1, wherein the device is additionally configured to make at least one spectroscopic measurement selected from the group consisting of infrared absorption, visible absorption, Raman, and fluorescence.

5. The device of claim 1, wherein the device is a catheter.

6. The device of claim 1 wherein the ring-shaped transducer array is located proximal to the therapy port and is aligned coaxially with a central axis of the therapy lumen within the distal end of the intravascular device.

7. The device of claim 1 wherein the ring-shaped transducer array surrounds a long axis of the therapy lumen within the distal end of the intravascular device to thereby maximize an inside diameter of the therapy lumen with respect to a diameter of the distal end of the device.

8. The device of claim 1 wherein the ring-shaped transducer array comprises a plurality of ultrasonic transmitters and a plurality of ultrasonic receivers that cooperate to image the tissue.

9. The device of claim 8 wherein the ring-shaped transducer array surrounds a long axis of the therapy lumen to thereby maximize an inside diameter of the therapy lumen.

10. The device of claim 8 wherein the ring-shaped transducer array is coaxially aligned with a long axis of the therapy lumen within the distal end of the intravascular device to thereby maximize an inside diameter of the therapy lumen with respect to a diameter of the distal end of the device.

11. The device of claim 1 wherein the sensor located distal to the therapy port comprises a Doppler sensor.

12. The device of claim 1 further comprising an acoustic therapy transducer at the distal end of the device, wherein the acoustic therapy transducer is configured to deliver acoustic waves to the tissue.

13. The device of claim 1, further comprising a distal tip portion distal to the distal end, wherein the distal tip portion comprises the distal-most tip and a side surface, wherein the side surface comprises the therapy port.

14. An intravascular device for simultaneous imaging, monitoring and therapy of tissue located within a patient, the intravascular device comprising:

a ring-shaped ultrasonic transducer array located at a distal end of the intravascular device, wherein the ring-shaped ultrasonic transducer array is configured to image the tissue;

a therapy lumen in fluid communication with a proximal end and the distal end of the intravascular device, wherein the therapy lumen passes through the ring-shaped ultrasonic transducer array and terminates in a therapy port at the distal end of the intravascular device to apply a therapy to the tissue; and

a blood flow sensor located distal to the therapy port at a distal-most tip of the distal end of the intravascular device, wherein the sensor is separate from the ring-shaped ultrasonic transducer array and is configured to measure blood flow in an environment associated with the tissue.

15. The intravascular device of claim 14 wherein the blood flow sensor is a Doppler sensor.

16. The intravascular device of claim 14 further comprising an acoustic therapy transducer at the distal end of the device, wherein the acoustic therapy transducer is configured to deliver acoustic waves to the tissue, and wherein the acoustic therapy transducer is separate from the ring-shaped ultrasonic transducer array and from the blood flow sensor.

17. The intravascular device of claim 14 wherein the ring-shaped ultrasonic transducer array is located proximal to the therapy port and coaxially with a long axis of the therapy lumen within the distal end of the intravascular device.

18. The intravascular device of claim 14 wherein the ring-shaped transducer array is located proximal to the therapy port and coaxially with a long axis of the therapy lumen within the distal end of the intravascular device to thereby maximize an inside diameter of the therapy lumen with respect to a diameter of the distal end of the intravascular device.

19. The intravascular device of claim 14 wherein the ring-shaped ultrasonic transducer array comprises a plurality of ultrasonic receivers that cooperate with a plurality of ultrasonic transmitters in the ring-shaped ultrasonic transducer array to image the tissue, wherein the ring-shaped ultrasonic transducer array is located proximal to the therapy port and coaxially with a long axis of the therapy lumen within the distal end of the intravascular device to thereby maximize an inside diameter of the therapy lumen with respect to a diameter of the distal end of the device.

20. The intravascular device of claim 14 wherein the therapy lumen passing through the ring-shaped transducer array is a drug delivery lumen configured to deliver a drug to the tissue through the therapy lumen.

21. The intravascular device of claim 14 wherein the therapy lumen passing through the ring-shaped transducer array is an aspiration lumen configured to aspirate the tissue through the therapy lumen.