Aspiration catheters for thrombus removal

• US 10,058,339 B2
• Filed: 05/27/2011
• Issued: 08/28/2018
• Est. Priority Date: 07/14/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Galdonik, Jason A., Anderson, Edward, Ganesan, Kavitha, Boldenow, Greg, Kirchgessner, John, Wlodarski, Grazyna
• Primary Examiner(s): WEISBERG, AMY REGINA
• Application Number:
  US13/117,452
• Publication Number:
  US 20110230859A1
• Time in Patent Office: 2,650 Days
• Field of Search: 604 9301-130, 604 35, 604118, 604131, 604173, 604532
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/2833 Locking means
• CPC Class Codes: A61B 17/2909 Handles
• CPC Class Codes: A61B 2017/0046 with a releasable handle; with handle and operating part separable
• CPC Class Codes: A61B 2017/22079 with suction of debris
• CPC Class Codes: A61B 2017/292 connection of actuating rod to handle, e.g. ball end in recess
• CPC Class Codes: A61B 2017/2923 Toothed members, e.g. rack and pinion
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61M 2025/0008 having visible markings on its surface, i.e. visible to the naked eye, for any purpose, e.g. insertion depth markers, rotational markers or identification of type
• CPC Class Codes: A61M 25/0108 using radio-opaque or ultrasound markers

Abstract

Systems for less invasive medical procedures comprise a filter device mounted on an integrated guiding structure and an aspiration catheter. These components can be used together or separately, and the system can be used with other medical devices that are designed for less invasive procedures, such as procedures in a patient'"'"'s vasculature. The filter device can involve improved torque coupling with a torque coupler associated with a resilient member that correspondingly also provides increased flexibility relative to an overtube that forms a tube for the remaining portions of the device. An actuation tool for the filter device used a systematic loading procedure for proper loading of the corewire and overtube into the actuation tool. A fiber cartridge comprises fibers loaded as a bundle into the cartridge for delivery with the ends of the fibers respectively bonded to radiopaque markers that can be visualized to come together when the filter is properly deployed. The aspiration catheter generally has a rapid exchange format. The catheter can have a radiopaque band that is held in place under metal wire embedded within the polymer forming the tube of the catheter. In some embodiments, the aspiration catheter has a small diameter distal portion that can access into small diameter vessels in which the distal portion has a smaller average diameter than the remaining tube of the catheter.

Claims

1. A method, of using an aspiration catheter in a thrombectomy procedure to treat an acute stroke condition, wherein the aspiration catheter comprises:

a proximal portion, a connection port connected to the proximal portion, a distal segment wherein the distal segment comprises a single lumen, and a tube section connected between the distal segment and the proximal portion,

wherein the distal segment consists of polymer forming a tubular element, metal wire reinforcement embedded in the polymer tubular element and extending around the tubular element and optionally one or more radiopaque marker bands, and has a constant outer diameter with a value that is from about 25 percent to about 95 percent of the average outer diameter of the tube section and comprises a distal opening at the distal end of the catheter, and wherein the catheter comprises a continuous lumen extending from the proximal portion through the tube section and the distal segment to the distal opening that provides fluid communication between the proximal portion and the distal opening, and the portion of the continuous lumen inside the distal segment has a smaller diameter relative to the diameter of the portion of the continuous lumen inside the tube section, the method comprising,

tracking the aspiration catheter along a guide structure to place the distal segment of the catheter into a small blood vessel with the distal opening of the catheter close to thrombus deposits within the vessel, and

applying suction through the proximal portion to effect aspiration at the distal opening of the catheter through the distal segment having an outer diameter with a value that is from about 25 percent to about 95 percent of the average outer diameter of the tube section to aspirate the thrombus deposits from the vessel,

wherein the small blood vessel is an artery of the brain, such that aspiration of the thrombus deposit treat the acute stroke condition.

2. The method of claim 1 wherein the suction rate is no more than about 125 percent of the vessel flow.

3. The method of claim 1 wherein the length of the distal segment is at least 1.0 centimeters.

4. The method of claim 1 wherein the distal segment comprises a rapid exchange segment.

5. The method of claim 1 wherein the distal portion of the distal segment is a curved distal tip.

6. The method of claim 5 wherein the angle of the curved tip relative to a straight tip is from about 10 degrees to about 60 degrees.

7. The method of claim 5 wherein the aspiration catheter further comprises a guide structure deflecting the curved distal tip.

8. The method of claim 1 wherein the constant diameter of the distal segment is no more than 0.040 inches.

9. The method of claim 1 wherein the distal segment has an average outer diameter of the tube ranges from 0.05 inches to 0.10 inches.

10. The method of claim 1 wherein the constant diameter of the distal segment is from about 45 percent to about 85 percent of the average outer diameter of the tube section.

11. The method of claim 1 wherein the constant diameter of the distal segment is from about 0.015 inches to about 0.120 inches.

12. The method of claim 1 wherein the distal segment comprises, thermoplastic polymer with embedded metal wire.

13. The method of claim 12 wherein the metal wire comprises Nitinol or stainless steel.

14. The method of claim 1 wherein the polymer comprise polyamides or nylons, polyurethanes, polydimethyl siloxane, or polytetrafluoroethylene.

15. The method of claim 1 wherein the aspiration catheter further comprises a radiopaque marker on the distal segment of the catheter.

16. The method of claim 1 wherein the aspiration catheter further comprises an exterior visual marker on the proximal portion of the catheter.

17. The method of claim 1 wherein the connection port is connected to an aspiration device.

18. The method of claim 1 wherein the connection port is connected to a syringe.

19. The method of claim 1 wherein the tip of the distal end of the catheter is beveled.

20. The method of claim 1 wherein the polymer comprises a radiopaque additive.