Medical devices containing rapamycin analogs

• US 10,058,641 B2
• Filed: 04/05/2016
• Issued: 08/28/2018
• Est. Priority Date: 09/10/2001
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Mollison, Karl W., LeCaptain, Angela M., Burke, Sandra E., Cromack, Keith R., Tarcha, Peter J., Chen, Yen-Chih J., Toner, John L.
• Primary Examiner(s): Berrios, Jennifer A
• Application Number:
  US15/091,473
• Publication Number:
  US 20160220739A1
• Time in Patent Office: 875 Days
• Field of Search: None
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/426 Immunomodulating agents, i.e. cytokines, interleukins, interferons
• CPC Class Codes: A61L 2300/604 Biodegradation
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 498/18 Bridged systems

Abstract

A medical device comprises a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to drugs of Formula (I). The drugs of Formula (I) can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

Claims

1. A medical device comprising a supporting structure having a coating on the surface thereof, wherein the coating comprises the therapeutic substance

2. The medical device of claim 1, wherein the coating comprises the biocompatible polymer containing phosphoryl choline side groups (PC polymer).

3. The medical device of claim 1, wherein the coating comprises the polyvinylpyrrolidone mixed with a polyester, a polyvinyl alcohol, or a polycarboxylic acid.

4. The medical device of claim 1, wherein the coating comprises the acrylic copolymer mixed with a polyolefin, a polyester, or a polyvinyl alcohol.

5. The medical device of claim 4, wherein the acrylic copolymer is hydrophobic.

6. The medical device of claim 4, wherein the acrylic copolymer is hydrophilic.

7. The medical device of claim 1, wherein the coating comprises the polyvinylpyrrolidone copolymer.

8. The medical device of claim 7, wherein the polyvinylpyrrolidone copolymer is hydrophilic.

9. The medical device of claim 1, wherein the coating comprises the polyester copolymer.

10. The medical device of claim 9, wherein the polyester copolymer is hydrophobic.

11. The medical device of claim 9, wherein the polyester copolymer is hydrophilic.

12. The medical device of claim 1, wherein the medical device is stent and said coating contains the therapeutic substance in an amount of 0.067 μ

g per mm stent to 8 μ

g per mm stent.

13. The medical device of claim 1, wherein said supporting structure is selected from the group consisting of coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature.