Time synchronization of multi-modality measurements

• US 10,063,369 B1
• Filed: 12/16/2016
• Issued: 08/28/2018
• Est. Priority Date: 12/16/2015
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Murphy, Mark, Mirov, Russell Norman, Jastrzebski, Michael
• Primary Examiner(s): Perez, James M
• Application Number:
  US15/381,646
• Time in Patent Office: 620 Days
• Field of Search: 375130, 375138, 375239, 375354-376
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0024 for multiple sensor units attached to the patient, e.g. using a body or personal area network
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: G01D 21/02 Measuring two or more variables by means not covered by a single other subclass

Abstract

The present disclosure is directed to waveform synchronization in multi-modal sensor networks. An example method includes providing a reference signal to a translation circuit. The method also includes generating, by the translation circuit, (i) a first synchronization signal capable of exciting a first emitter to produce a first wave in a first modality and (ii) a second synchronization signal capable of exciting a second emitter to produce a second wave in a second modality, wherein a modality is a domain within a form of energy. The method further includes producing, by the first emitter, first wave in the first modality and, by the second emitter, the second wave in the second modality, wherein the first wave is substantially directed toward a first sensor capable of interacting with the first wave, and wherein the second wave substantially directed toward a second sensor capable of interacting with the second wave.

Claims

1. A method comprising:

providing a reference signal to a translation circuit;

generating, by the translation circuit based on the reference signal, (i) a first synchronization signal capable of exciting a first emitter to produce a first wave in a first modality and (ii) a second synchronization signal capable of exciting a second emitter to produce a second wave in a second modality, wherein a modality is a domain within a form of energy, and wherein the first modality is different from the second modality; and

producing, by the first emitter, the first wave in the first modality and, by the second emitter, the second wave in the second modality, wherein the first wave is substantially directed toward a first physiological sensor configured to receive the first wave and to associate a first sensed physiological parameter with a received portion of the first wave, and wherein the second wave is substantially directed toward a second physiological sensor configured to receive the second wave and to associate a second sensed physiological parameter with a received portion of the second wave.

2. The method of claim 1, wherein providing the reference signal comprises:

generating, by a signal generator, the reference signal, wherein the reference signal is capable of being transmitted within a third modality; and

transmitting the reference signal to the translation circuit over the third modality.

3. The method of claim 2, wherein generating the reference signal comprises:

generating the reference signal based on a time encoding of a pseudorandom sequence.

4. The method of claim 2, wherein generating the reference signal comprises:

generating the reference signal based on a time encoding of a known sequence of values.

5. The method of claim 1, wherein the reference signal has a reference frequency, and wherein generating the first synchronization signal comprises:

converting the reference signal from the reference frequency to a first frequency to generate the first synchronization signal, wherein the first frequency is within the domain defined by the first modality.

6. The method of claim 1, wherein the reference signal has a reference amplitude, and wherein generating the first synchronization signal comprises:

amplifying the reference signal from the reference amplitude to a first amplitude to generate the first synchronization signal, wherein the first amplitude is within a threshold range of amplitudes within the domain defined by the first modality.

7. The method of claim 1, wherein the reference signal is an analog signal, and wherein generating the first synchronization signal comprises:

sampling the reference signal to generate reference data representative of the reference signal; and

generating, as the first synchronization signal, a digital signal as a pulsed modulation of the reference data.

8. The method of claim 1, wherein the reference signal is a digital signal including digital data, and wherein generating the first synchronization signal comprises:

generating, as the first synchronization signal, an analog signal based on the digital data within the digital signal.

9. The method of claim 1, wherein producing the first wave and the second wave comprises:

causing the first emitter to produce the first wave at a first time; and

causing the second emitter to produce the second wave at a second time, wherein the second time occurs after the first time.

10. The method of claim 9, further comprising:

determining the second time based at least in part on known propagation velocities of the first wave and the second wave.

11. A system comprising:

a signal generator operable to generate a reference signal;

a translation circuit operable to convert the reference signal into a first synchronization signal and a second synchronization signal, wherein the first synchronization signal includes characteristics that excite emitters in a first modality, wherein the second synchronization signal includes characteristics that excite emitters in a second modality, wherein a modality is a domain within a form of energy, and wherein the first modality is different from the second modality;

a first emitter operable to receive the first synchronization signal and responsively produce a first synchronization wave in a first modality, wherein the first synchronization wave is to be directed toward a first physiological sensor configured to receive the first synchronization wave and to associate a first sensed physiological parameter with a received portion of the first synchronization wave; and

a second emitter operable to receive the second synchronization signal and responsively produce a second synchronization wave in a second modality, wherein the second synchronization wave is to be directed toward a second physiological sensor configured to receive the second synchronization wave and to associate a second sensed physiological parameter with a received portion of the second synchronization wave.

12. The system of claim 11, wherein the signal generator and the translation circuit are electrically coupled by a transmission medium, and wherein the reference signal is provided to the translation circuit via the transmission medium.

13. The system of claim 11, wherein the translation circuit and the first emitter are electrically coupled by a transmission medium, and wherein the first synchronization signal is provided to the first emitter via the transmission medium.

14. The system of claim 11, wherein the first physiological sensor includes a first clock, wherein the second physiological sensor includes a second clock, and wherein the first clock is different from the second clock.

15. The system of claim 11, further comprising:

a storage medium operable to store information output from a first sensor and a second sensor.

16. The system of claim 11, further comprising the first or second physiological sensor.

17. A method comprising:

producing, by a first emitter, a first wave in a first modality;

producing, by a second emitter, a second wave in a second modality, wherein a modality is a domain within a form of energy, and wherein the first modality is different from the second modality;

capturing, by a first physiological sensor, a first segment of a first waveform including at least a portion of the first wave and first sensed physiological information, wherein the first segment begins at a first time offset relative to the start of the first waveform;

capturing, by a second physiological sensor, a second segment of a second waveform including at least a portion of the second wave and second sensed physiological information, wherein the second segment begins at a second time offset relative to the start of the second waveform; and

based on at least the first time offset and the second time offset, providing a time-synchronized output indicative of at least one of (i) a portion of the first waveform and the first sensed physiological information and (ii) a portion of the second waveform and the first sensed physiological information.

18. The method of claim 17, further comprising:

generating, by a translation circuit based on a reference signal, (i) a first synchronization signal that interacts with the first emitter to produce the first wave in the first modality and (ii) a second synchronization signal that interacts with the second emitter to produce the second wave in the second modality.

19. The method of claim 18, further comprising:

generating, by a signal generator, the reference signal; and

providing the reference signal to the translation circuit.

20. The method of claim 17, wherein providing the time-synchronized output comprises:

producing, by an image forming apparatus, a graphical depiction of the portion of the first waveform and the portion of the second waveform on a printing medium.

21. The method of claim 17, wherein providing the time-synchronized output comprises:

producing, by an image forming apparatus, a graphical representation of the portion of the first waveform and the portion of the second waveform on a display device.

22. A system comprising:

a signal generator operable to generate a reference signal; and

a synchronization device coupled to the signal generator and configured to receive the reference signal from the signal generator, the synchronization device including a plurality of receptacles, each receptacle of the plurality of receptacles configured to physically engage with a physiological sensing device and transmit the reference signal simultaneously with the other receptacles, one or more of the physiological sensing devices, when engaged, being configured to detect and store the reference signal with a respective timestamp, wherein each respective timestamp indicates a time offset for data collected by the respective physiological sensing device.

23. The system of claim 22, wherein the synchronization device transmits the reference signal to the plurality of receptacles as an electrical waveform.

24. The system of claim 23, wherein the synchronization device includes a base and a top plate, the base including the plurality of receptacles, the top plate configured to be assembled over the base when one or more physiological sensing devices are disposed in respective receptacles between the base and the top plate.

25. The system of claim 23, wherein at least one of the physiological sensing devices includes electrocardiogram (ECG) electrodes.

26. The system of claim 22, wherein the physiological sensing devices includes at least one first physiological sensing device operable to detect signals according to a first modality and at least one second physiological sensing device operable to detect signals according to a second modality.

27. The system of claim 26, wherein the synchronization device transmits the reference signal to the at least one first physiological sensing device according to the first modality and the at least one second physiological sensing device according to the second modality.

28. The system of claim 26, wherein the at least one second physiological sensing device is further operable to detect signals according to the first modality, and the synchronization device transmits the reference signal to the at least one first physiological sensing device and the at least one second physiological sensing device according to the first modality.