Method and apparatus for sensory field assessment

• US 10,064,548 B2
• Filed: 11/07/2008
• Issued: 09/04/2018
• Est. Priority Date: 11/09/2007
• Status: Active Grant

• Current Assignee: KONAN MEDICAL USA, INC.
• Original Assignee: Australian National University
• Inventors: Maddess, Teddy Lee, James, Andrew Charles
• Primary Examiner(s): Dougherty, Sean
• Assistant Examiner(s): FERNANDES, PATRICK M
• Application Number:
  US12/741,762
• Publication Number:
  US 20100249532A1
• Time in Patent Office: 3,588 Days
• Field of Search: 351224, 351246, 600300, 600558
• CPC Class Codes: A61B 3/024 for determining the visual field, e.g. perimeter types
• CPC Class Codes: A61B 5/378 Visual stimuli

Abstract

A method for assessing the function of at least one sensory field of a subject, and apparatus and systems for carrying out the method, the method comprising: using a display, presenting stimuli to selected locations of the sensory field, the selected locations being centered at points on a sampling grid spanning a portion of the sensory field, wherein the individual stimuli if presented simultaneously at the sampling grid points would overlap in the space defined by the sensory dimensions of the field; using a sensor, detecting responses in the subject'"'"'s sensory field evoked by the stimuli; and processing the detected responses to relate them to the function of the subject'"'"'s sensory field at the selected locations.

Claims

1. A method for assessing a function of a visual sensory field of a subject, the method comprising:

obtaining a system comprising a processor and a sensor for use with the processor,

the processor configured to present on a display or optical system visual stimuli over selected areas of the visual sensory field defined by sensory spatial dimensions defined in units of angle or length of the visual sensory field, the selected areas being centered at points on a sampling grid of the display or optical system wherein individual visual stimuli

each spans a portion of the visual sensory field, and

each is selectively presented in a distinct associated area,

wherein

the distinct associated area of at least one of said individual visual stimuli overlaps a portion less than all the distinct associated area of at least one other of said visual stimuli such that spatial aliasing of the visual stimuli of the sampling grid is minimized, and

profiles of the visual stimuli are smoothly varying such that the individual visual stimuli comprise mainly spatial frequencies that are less than or equal to a highest spatial frequency that can be represented by the sampling grid, wherein the highest spatial frequency is a Nyquist sampling frequency defined by a density of the visual stimuli in the sampling grid,

the sensor configured to detect responses in the subject'"'"'s visual sensory field evoked by the stimuli and generate inputs representative of the responses;

using the processor to present visual stimuli including the one and one other visual stimuli;

using the sensor to detect responses in the subject'"'"'s visual sensory field evoked by the visual stimuli including responses evoked by the one and the one other visual stimuli and generate the inputs representative of the responses evoked by at least the one and the one other visual stimuli,

the processor configured so that the overlap of the distinct associated areas of the at least one and at least one other visual stimuli presented by the processor and smooth varying of the profiles of the visual stimuli presented by the processor avoid undersampling and reduce distorting effects of aliasing of high spatial frequency variations in visual function of the subject; and

through the processor, processing the inputs to thereby estimate a functional response of the subject'"'"'s visual sensory field at the selected areas using the detected responses.

2. The method as claimed in claim 1 wherein the sensory field has a horizontal meridional axis and a vertical meridional axis, and the visual stimuli presented by the processor do not overlap with either the vertical or horizontal meridional axes of the sensory field.

3. The method as claimed in claim 2 wherein the visual stimuli are presented by the processor to each span an area of the sensory field such that, in use, each visual stimulus stimulates equal numbers of sensory neurons in the sensory field.

4. The method as claimed in claim 1 wherein the sampling grid is presented in a polar representation coordinates of the polar representation being linear or nonlinear functions of radius and polar angle.

5. The method as claimed in claim 1 wherein the visual stimuli are presented by the processor so as to produce a perception of a spatially frequency doubled arrangement such that perceived spatial frequencies are between 30% lower than frequency doubled frequencies and 200% of the frequency doubled frequencies.

6. The method as claimed in claim 1 wherein the step of using the sensor to detect responses comprises using the sensor to detect responses in the subject'"'"'s sensory field evoked by the visual stimuli by a method selected from the group consisting of:

detecting electrical potentials;

detecting changes in magnetic or electromagnetic radiation;

detecting changes in acoustic signals;

detecting changes in the responses of the subject'"'"'s pupil; and

detecting changes in movements of the subject'"'"'s eye, or a behavioral response of the subject.

7. The method as claimed in claim 1 wherein the step of using the processor to present visual stimuli comprises using the processor to present visual stimuli in a multifocal arrangement and the processing comprises the step of computing through the processor linear and/or nonlinear weighting functions that characterize the response of each stimulated portion of the sensory field stimulated by the visual stimuli.

8. The method as claimed in claim 7 wherein the step of using the processor to present visual stimuli comprises using the processor to concurrently present visual stimuli that are temporally sparsely presented, wherein temporally sparsely presented is the presentation of visual stimuli transiently between longer intervals of null stimulation.

9. The method as claimed in claim 7 wherein the step of using the processor to present visual stimuli comprises using the processor to concurrently present visual stimuli that are spatially sparsely presented, wherein spatially sparsely presented visual stimuli are presented such that if a given point on the sampling grid is active, the points on the sampling grid adjacent to the given point is not simultaneously active.

10. The method as claimed in claim 7 wherein the step of using the processor to present visual stimuli comprises using the processor to concurrently present visual stimuli that are temporally sparsely presented and spatially sparsely presented wherein temporally sparsely presented is the presentation of visual stimuli transiently between longer intervals of null stimulation and, wherein spatially sparsely presented visual stimuli are presented such that a given point on the sampling grid adjacent to an active point is not simultaneously active.

11. The method as claimed in claim 9 wherein the step of using the processor to present visual stimuli comprises using the processor to present two or more spatially sparse visual stimuli simultaneously.

12. The method as claimed in claim 1 wherein the step of using the processor to present visual stimuli comprises using the processor to present visual stimuli at locations on a multi-dimensional sampling grid.

13. The method as claimed in claim 1 wherein the step of using the processor to present visual stimuli comprises using the processor to present visual stimuli at locations on a regular sampling grid.

14. The method as claimed in claim 1 wherein the step of using the processor to present visual stimuli comprises using the processor to present visual stimuli at locations on an irregular sampling grid.

15. The method as claimed in claim 1 further comprising the steps of obtaining one or more filters having an aspect ratio of 3 to 1, the one or more filters being edge preserving filters, and enhancing generally elongated features within a polar representation of a space defined by sensory dimensions of the sensory field by operation of the one or more filters.

16. The method as claimed in claim 15 wherein the step of processing the inputs comprises transforming the detected responses to a rectilinear representation of the stimulated portions of the sensory field.

17. The method as claimed in claim 1 wherein the step of processing the inputs comprises transforming the detected responses to a polar representation of the stimulated portions of the sensory field.

18. The method as claimed in claim 1 wherein the sensory field under assessment is a plurality of dimensions, each dimension being one or two visual sensory fields of the subject.

19. The method as claimed in claim 1 wherein the step of using the processor to present visual stimuli comprises using the processor to present visual at least two stimuli and the sensory field under assessment is at least one visual sensory field of the subject encompassing a visual field sensitivity of one or both retinas of the subject.

20. The method as claimed in claim 19 comprising using the system to assess the visual sensory field of one or both retinas of the subject using a method for diagnosing a condition causing visual impairment.

21. The method as claimed in claim 20 wherein the condition is at least one of glaucoma, age-related macular degeneration, diabetic retinopathy, stroke, and multiple sclerosis.

32. The method as claimed in claim 20 wherein the visual impairment is localized to a part of the sensory fields.

22. An apparatus for assessing a function of a visual sensory field of a subject, the apparatus comprising:

a display or optical system controlled by a processor configured to present visual stimuli over selected areas of the visual sensory field, the selected areas being centered at points on a sampling grid of the display or optical system with each presented visual stimuli spanning a portion of the visual sensory field and presented in a distinct associated area, the distinct associated area of at least one of said individual visual stimuli overlapping a portion less than all the distinct associated area of at least one other of said visual stimuli such that spatial aliasing of the visual stimuli on the sampling grid is thereby minimized, wherein profiles of the visual stimuli are smoothly varying such that the individual visual stimuli comprise mainly spatial frequencies that are less than or equal to a highest spatial frequency that can be represented by the sampling grid, wherein the highest spatial frequency is a Nyquist sampling frequency defined by a density of the visual stimuli in the sampling grid,

the processor configured so that the overlap of the distinct associated areas of the at least one and at least one other visual stimuli presented by the processor and smooth varying of the profiles of the visual stimuli presented by the processor avoid undersampling and reduce distorting effects of aliasing of high spatial frequency variations in visual function of the subject to thereby give an accurate identification of variation in the user'"'"'s visual function across a measured visual field; and

a sensor adapted to detect responses in the subject'"'"'s visual sensory field evoked by the visual stimuli,

said processor being operably connected to said sensor and to said display or optical system and configured to process the detected responses to estimate a functional response of the subject'"'"'s visual sensory field at the selected locations using the detected responses.

23. The apparatus as claimed in claim 22 wherein the processor is configured so that each presented visual stimulus spans an area of the sensory field such that, in use, each visual stimulus stimulates equal numbers of sensory cells in the sensory field.

24. The apparatus as claimed in claim 22 wherein the apparatus is configured to present the sampling grid in a polar representation of a pace defined by sensory dimensions of the sensory field, coordinates of the polar representation being linear or nonlinear functions of radius and polar angle.

25. The apparatus as claimed in claim 22 further comprising one or more filters for enhancement of generally elongated features with the polar sampling grid, the one or more filters being edge preserving filters.

26. The apparatus as claimed in claim 22, the apparatus configured to compute linear and/or nonlinear weighting functions that characterize the response of each stimulated portion of the sensory field stimulated by the visual stimuli.

27. The apparatus as claimed in claim 22 wherein the apparatus is configured to assess a visual field sensitivity of one or both retinas of the subject and further comprises a display device selected from the group consisting of a CRT, LCD, plasma, LED, and OLED image display screen.

28. The apparatus as claimed in claim 22 wherein the sensor for detecting responses evoked by the visual stimuli is configured to detect neural or behavioral responses from the subject.

29. The apparatus as claimed in claim 22 further comprising a memory for recording the responses.

30. The apparatus claimed in claim 22 wherein the processor is configured to present visual stimuli so as to produce a perception of a spatially frequency doubled arrangement such that perceived spatial frequencies are between 30% lower than frequency doubled frequencies and 200% of the frequency doubled frequencies.

31. The apparatus as claimed in claim 22 wherein the apparatus is configured to assess a condition causing impairment of the subject'"'"'s visual fields including any one or more of glaucoma, age-related macular degeneration, diabetic retinopathy, stroke, and multiple sclerosis affecting one or both eyes of the subject.