Electrocardiography monitoring system and method

• US 10,064,566 B2
• Filed: 11/24/2014
• Issued: 09/04/2018
• Est. Priority Date: 11/25/2013
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Atallah, Louis Nicolas, Meftah, Mohammed, Schellekens, Martijn, Serteyn, Aline Anne Marie, Vullings, Rik, Bergmans, Jan
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Piateski, Erin M
• Application Number:
  US15/038,289
• Publication Number:
  US 20160287129A1
• Time in Patent Office: 1,380 Days
• Field of Search: 600372, 600547, 600384, 600511, 600481, 600393, 600509, 600512, 607 8
• CPC Class Codes: A61B 2503/04 Babies, e.g. for SIDS detection
• CPC Class Codes: A61B 2503/045 Newborns, e.g. premature baby monitoring
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 2562/0214 Capacitive electrodes
• CPC Class Codes: A61B 5/276 Protection against electrode failure
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/302 for capacitive or ionised electrodes, e.g. metal-oxide-semiconductor field-effect transistors [MOSFET]
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/327 Generation of artificial ECG signals based on measured signals, e.g. to compensate for missing leads
• CPC Class Codes: A61B 5/335 using integrated circuit memory devices
• CPC Class Codes: A61B 5/341 Vectorcardiography [VCG]
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/6892 Mats
• CPC Class Codes: A61B 5/7214 using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: A61G 11/00 Baby-incubators; Couveuses

Abstract

Systems and methods for electrocardiography monitoring use multiple capacitive sensors in order to determine reliable measurements of electrophysiological information of a patient. Relative coupling strength and/or reliability is used to select dynamically which sensors to use in order to determine, in particular, an electrocardiogram of the patient.

Claims

1. A system for electrocardiography (ECG) monitoring of a subject, the system comprising:

multiple non-invasive capacitive sensors configured to generate output signals conveying electrophysiological information of the subject, wherein the multiple capacitive sensors include at least three non-invasive capacitive sensors that are free from attachment to the subject, wherein the non-invasive capacitive sensors are further configured to emit carrier signals, and wherein the generated output signals of an individual one of the non-invasive capacitive sensors are electrophysiological signals of the subject, the physiological signals including a representation of the carrier signals;

computer program modules; and

one or more processors configured to execute the computer program modules, the computer program modules comprising;

a coupling module configured to determine coupling levels for individual ones of the non-invasive capacitive sensors based on the generated output signals

a selection module configured to select one or more capacitive sensors based on the determined coupling levels; and

a reconstruction module configured to determine an electrocardiogram (ECG) signal based on the generated output signals from the selected one or more capacitive sensors;

wherein the coupling module is further configured to determine which capacitive sensor has the highest coupling level, and wherein selection of the one or more capacitive sensors is based on one or more correlation coefficients between the output signals generated by the capacitive sensor having the highest coupling level and the output signals generated by one or more other capacitive sensors, the correlation coefficient including at least one of a Pearson'"'"'s correlation coefficient and a rank correlation coefficient.

2. The system of claim 1, wherein the coupling module is further configured to determine which capacitive sensor has the highest coupling level.

3. The system of claim 1, wherein selection of the one or more capacitive sensors is further based on spatial distribution of the one or more capacitive sensors.

4. The system of claim 1, wherein the reconstruction module is configured to determine the electrocardiogram signal by determining a vectorcardiogram (VCG) signal based on the generated output signals from the selected one or more capacitive sensors, approximating the vectorcardiogram signal by an ellipse having a long axis, and projecting the vectorcardiogram signal onto the long axis of the ellipse.

5. The system of claim 1, wherein the multiple non-invasive capacitive sensors are configured to generate the output signals non-invasively and motion-tolerant to limited motion of a subject.

6. A method of providing electrocardiography (ECG) monitoring of a subject, the method comprising:

emitting, by multiple non-invasive capacitive sensors that are not in physical contact with the patient, carrier signals, wherein the multiple capacitive sensors include at least three non-invasive capacitive sensors;

generating, by the multiple capacitive sensors, output signals conveying electrophysiological information of the subject, wherein the output signals of an individual one of the non-invasive capacitive sensors are electrophysiological signals of the subject, the physiological signals including a representation of the carrier signals;

determining coupling levels for individual ones of the capacitive sensors based on the generated output signals including determining which capacitive sensor has the highest coupling level;

selecting one or more capacitive sensors based on the determined coupling levels based on one or more correlation coefficients between the output signals generated by the capacitive sensor having the highest coupling level and the output signals generated by one or more other capacitive sensors; and

determining an electrocardiogram (ECG) signal based on the generated output signals from the selected one or more capacitive sensors;

wherein the step of selecting one or more capacitive sensors is based on one or more correlation coefficients between the output signals generated by the capacitive sensor having the highest coupling level and the output signals generated by one or more other capacitive sensors, the correlation coefficient including at least one of a Pearson'"'"'s correlation coefficient and a rank correlation coefficient.

7. The method of claim 6, wherein selection of the one or more capacitive sensors is further based on spatial distribution of the one or more capacitive sensors.

8. The method of claim 6, wherein determining the electrocardiogram (ECG) signal includes:

determining a vectorcardiogram (VCG) signal based on the generated output signals from the selected one or more capacitive sensors;

approximating the vectorcardiogram signal by an ellipse having a long axis; and

projecting the vectorcardiogram signal onto the long axis of the ellipse.

9. The method of claim 6, wherein the multiple non-invasive capacitive sensors are configured to generate the output signals non-invasively and motion-tolerant to limited motion of a subject.

10. The method of claim 6, wherein the multiple non-invasive capacitive sensors are free from attachment to the subject.

11. A system configured to provide electrocardiography (ECG) monitoring of a subject, the system comprising:

means for emitting carrier signals including multiple elements configured to emit carrier signals, wherein the multiple elements include at least three non-invasive elements;

means for generating output signals conveying electrophysiological information of the subject, wherein the output signals of an individual element include a representation of the carrier signals emitted by the individual element, wherein the means for generating output signals is non-invasive to the subject;

means for determining coupling levels for the means for emitting carrier signals based on the generated output signals;

means for selecting one or more elements of the means for emitting carrier signals based on the determined coupling levels; and

means for determining an electrocardiogram (ECG) signal based on the generated output signals from the selected elements selected by the means for selecting;

wherein the means for determining coupling levels is configured to determine which non-invasive element has the highest coupling level, and wherein the selection means for selecting is based on one or more correlation coefficients between the output signals generated by the non-invasive element having the highest coupling level and the output signals generated by one or more other non-invasive element, the correlation coefficient including at least one of a Pearson'"'"'s correlation coefficient and a rank correlation coefficient.

12. The system of claim 11, wherein operation of the means for selecting is further based on spatial distribution of the one or more elements of the means for emitting carrier signals.

13. The system of claim 11, wherein the means for determining the electrocardiogram (ECG) signal includes:

means for determining a vectorcardiogram signal based on the generated output signals from the selected one or more capacitive sensors;

means for approximating the vectorcardiogram signal by an ellipse having a long axis; and

means for projecting the vectorcardiogram signal onto the long axis of the ellipse.

14. The system of claim 11, wherein the means for generating the output signal are configured to generate the output signals non-invasively and motion-tolerant to limited motion of a subject.

15. The system of claim 11, wherein the means for emitting the carrier signals and the means for generating the output signals comprise at least three multiple non-invasive capacitive sensors.

16. The system of claim 15, wherein the at least three multiple non-invasive capacitive sensors are free from attachment to the subject.

17. The system of claim 11, wherein the means for determining coupling levels, the means for selecting one or more elements of the means for emitting carrier signals, and the means for determining the ECG signal each comprise at least one electronic processor.