Sensory stimuli to increase accuracy of sleep staging

• US 10,064,578 B2
• Filed: 01/28/2014
• Issued: 09/04/2018
• Est. Priority Date: 01/29/2013
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V., Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Koninklijke Philips N.V., Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Garcia Molina, Gary Nelson, Pastoor, Sander Theodoor, Pfundtner, Stefan, Riedner, Brady Alexander, Bellesi, Michele, Tononi, Giulio
• Primary Examiner(s): Thomson, William
• Assistant Examiner(s): HUH, VYNN V
• Application Number:
  US14/764,063
• Publication Number:
  US 20150359482A1
• Time in Patent Office: 1,680 Days
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/398 Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
• CPC Class Codes: A61B 5/4812 Detecting sleep stages or cycles
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Systems and methods to detect sleep stages of a subject analyze physiological parameters of the subject in combination with a subject'"'"'s reactions to stimuli of increasing intensity and/or stimuli having different modalities. Stimuli are provided until a predetermined level of probability is reached for the accuracy of an estimation of the sleep stage of the subject.

Claims

1. A system configured to facilitate sleep stage detection, the system comprising:

a stimulus source configured to provide stimuli to a subject;

one or more sensors that generate output signals conveying information related to one or more physiological parameters of the subject;

an electronic storage configured to store machine readable instructions; and

one or more hardware processors configured by the machine readable instructions to;

analyze, based on the one or more physiological parameters, reactions to the stimuli provided by the stimulus source;

estimate a sleep stage of the subject based on one or both of the analyzed reactions and/or the one or more physiological parameters;

determine an accuracy of the estimation of the sleep stage;

determine whether the accuracy of the estimation of the sleep stage breaches a predetermined threshold; and

responsive to the accuracy of the estimation of the sleep stage failing to breach the predetermined threshold, perform one or more iterations of the following operations until the accuracy of the estimation of the sleep stage breaches the predetermined threshold;

control the stimulus source to provide a reassessment stimulus to the subject, wherein the reassessment stimulus comprises one or more stimuli of increasing intensity and/or varying modality;

analyze a reaction to the reassessment stimulus; and

reassess one or both of the estimation of the sleep stage and/or the accuracy of the estimation of the sleep stage based on the analyzed reaction to the reassessment stimulus.

2. The system of claim 1, wherein the one or more hardware processors are further configured to determine the one or more physiological parameters based on the generated output signals.

3. The system of claim 1, wherein the one or more physiological parameters pertain to brain function of the subject, the one or more physiological parameters that pertain to brain function comprising electroencephalography (EEG), electromyography (EMG), and/or electrooculography (EOG) parameters.

4. The system of claim 1, wherein the one or more physiological parameters pertain to movement of the subject.

5. The system of claim 1, wherein the one or more hardware processors are further configured to determine effectiveness of different stimuli to evoke reactions corresponding to a higher accuracy of the estimation of the sleep stage, wherein effectiveness is quantified by a difference between a level of intensity of a particular stimulus and a predetermined maximum level of intensity for the particular stimulus.

16. The system of claim 1, wherein the one or more hardware processors are further configured to adjust intensity of the stimuli and/or the reassessment stimulus provided to the subject based on a level of environmental ambient noise.

6. A method for facilitating sleep stage detection with a detection system, the detection system comprising a stimulus source, one or more sensors, and one or more hardware processors, the method comprising:

providing, with the stimulus source, stimuli to a subject;

generating, with the one or more sensors, electronic output signals conveying information related to one or more physiological parameters of the subject;

analyzing, with the one or more hardware processors, based on the one or more physiological parameters, reactions to the stimuli;

generating, with the one or more hardware processors, an estimation of a sleep stage of the subject based on the one or more physiological parameters;

determining, with the one or more hardware processors, an accuracy of the estimation of the sleep stage;

determining, with the one or more hardware processors, whether the accuracy of the estimation of the sleep stage breaches a predetermined threshold; and

responsive to the accuracy of the estimation of the sleep stage failing to breach the predetermined threshold, performing one or more iterations of the following operations until the accuracy of the estimation of the sleep stage breaches the predetermined threshold;

controlling, with the one or more hardware processors, the stimulus source to provide a reassessment stimulus to the subject, wherein the reassessment stimulus comprises one or more stimuli of increasing intensity and/or varying modality;

analyzing, with the one or more hardware processors, a reaction to the reassessment stimulus based on one or more physiological parameters; and

reassessing, with the one or more hardware processors, one or both of the estimation of the sleep stage and/or the accuracy of the estimation of the sleep stage based on the analyzed reaction to the reassessment stimulus.

7. The method of claim 6, further comprising:

determining the one or more physiological parameters based on the generated output signals.

8. The method of claim 6, wherein the one or more physiological parameters pertain to brain function of the subject, the one or more physiological parameters that pertain to brain function comprising electroencephalography (EEG), electromyography (EMG), and/or electrooculography (EOG) parameters.

9. The method of claim 6, wherein the one or more physiological parameters pertain to movement of the subject.

10. The method of claim 6, further comprising:

determining effectiveness of different stimuli to evoke reactions corresponding to a higher accuracy of the estimation of the sleep stage, wherein effectiveness is quantified by a difference between a level of intensity of a particular stimulus and a predetermined maximum level of intensity for the particular stimulus.

17. The method of claim 6, wherein the intensity of the stimuli and/or the reassessment stimulus provided to the subject is adjusted, by the one or more hardware processors, based on a level of environmental ambient noise.

11. A system configured to facilitate sleep stage detection, the system comprising:

means for providing stimuli to a subject;

means for generating output signals conveying information related to one or more physiological parameters of the subject;

means for analyzing reactions to the stimuli, wherein operations of the means for analyzing is based on the one or more physiological parameters;

means for generating an estimation of a sleep stage of the subject based on the one or more physiological parameters;

means for determining an accuracy of the estimation of the sleep stage;

means for determining whether the accuracy of the estimation of the sleep stage breaches a predetermined threshold;

responsive to the accuracy of the estimation of the sleep stage failing to breach the predetermined threshold, means for performing one or more iterations of the following operations until the accuracy of the estimation of the sleep stage breaches the predetermined threshold;

means for controlling the means for providing stimuli to provide a reassessment stimulus to the subject, wherein the reassessment stimulus comprises one or more stimuli of increasing intensity and/or varying modality;

means for analyzing a reaction to the reassessment stimulus based on one or more physiological parameters; and

means for reassessing one or both of the estimation of the sleep stage and/or the accuracy of the estimation of the sleep stage based on the analyzed reaction to the reassessment stimulus.

12. The system of claim 11, further comprising:

means for determining the one or more physiological parameters based on the generated output signals.

13. The system of claim 11, wherein the one or more physiological parameters pertain to brain function of the subject, the one or more physiological parameters that pertain to brain function comprising electroencephalograph);

(EEG), electromyography (EMG), and/or electrooculography (EOG) parameters.

14. The system of claim 11, wherein the one or more physiological parameters pertain to movement of the subject.

15. The system of claim 11, further comprising:

means for determining effectiveness of different stimuli to evoke reactions corresponding to a higher accuracy of the estimation of the sleep stage, wherein effectiveness is quantified by a difference between a level of intensity of a particular stimulus and a predetermined maximum level of intensity for the particular stimulus.

18. The system of claim 11, wherein the intensity of the stimuli and/or the reassessment stimulus provided to the subject is adjusted based on a level of environmental ambient noise.