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Bupropion as a modulator of drug activity

  • US 10,064,857 B2
  • Filed: 08/30/2017
  • Issued: 09/04/2018
  • Est. Priority Date: 11/05/2013
  • Status: Active Grant
First Claim
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1. A method, comprising administering for at least eight consecutive days a combination of dextromethorphan and bupropion to a human being, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the combination is administered in a dosage form having properties effective for providing a Cmax of dextromethorphan on the eighth day of about 40 ng/mL to about 75 ng/mL, and wherein on the eighth day the combination is administered the Cmax of dextromethorphan is at least about 15 times the Cmax of dextromethorphan that would be achieved by administering the same amount of dextromethorphan without bupropion for eight consecutive days.

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