Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
First Claim
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1. A thermoformed, tamper-resistant pharmaceutical dosage form comprising:
- a) a pharmacologically active ingredient selected from the group consisting of opioids, stimulants, tranquilizers, and narcotics;
b) a polyalkylene oxide having a weight average molecular weight of more than 200,000 g/mol;
c) a zinc component, wherein said zinc component has a zinc content of at most 1,000 ppm, relative to a total weight of the dosage form; and
d) an antioxidant.
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Abstract
A thermoformed, tamper-resistant pharmaceutical dosage form comprises:
- a) a pharmacologically active ingredient;
- b) a polyalkylene oxide having a weight average molecular weight of more than 200,000 g/mol; and
- c) a zinc component, wherein the content of said zinc component is at least 1 ppm, relative to the total weight of the pharmaceutical dosage form.
When the pharmacologically active ingredient is effective against pain, the pharmaceutical dosage form may be used in a method of treating pain. When the pharmacologically active ingredient has abuse potential, the pharmaceutical dosage form may be used in a method of reducing the incidence of the abuse of said pharmacologically active ingredient.
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Citations
28 Claims
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1. A thermoformed, tamper-resistant pharmaceutical dosage form comprising:
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a) a pharmacologically active ingredient selected from the group consisting of opioids, stimulants, tranquilizers, and narcotics; b) a polyalkylene oxide having a weight average molecular weight of more than 200,000 g/mol; c) a zinc component, wherein said zinc component has a zinc content of at most 1,000 ppm, relative to a total weight of the dosage form; and d) an antioxidant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification