PDLLA stent coating

• US 10,064,982 B2
• Filed: 08/21/2015
• Issued: 09/04/2018
• Est. Priority Date: 06/27/2001
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Roorda, Wouter E., Ding, Ni
• Primary Examiner(s): Mathew, Seema
• Application Number:
  US14/832,889
• Publication Number:
  US 20150359943A1
• Time in Patent Office: 1,110 Days
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30064 Coating or prosthesis-covering structure made of biodegradable material
• CPC Class Codes: A61K 31/436 the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• CPC Class Codes: A61K 31/439 the ring forming part of a bridged ring system, e.g. quinuclidine 8-azabicyclo [3.2.1] octanes A61K31/46
• CPC Class Codes: A61L 2300/216 with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices
• CPC Class Codes: A61L 2420/06 Coatings containing a mixture of two or more compounds
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B05D 1/02 performed by spraying

Abstract

An amorphous PDLLA stent coating for drug delivery is disclosed.

Claims

1. A stent comprising a coating, the coating consisting of a poly(D,L-lactic acid) (PDLLA) and a macrocyclic drug, wherein the PDLLA has a degree of crystallinity of less than 20 percent, the measurement being by weight of the amount of polymer that is in the form of crystallites as measured by differential scanning calorimetry, wherein the coating has a thickness of 0.05 microns to 10 microns, and wherein the stent on which the coating is disposed is made from a bioabsorbable polymer.

2. The stent of claim 1, wherein the drug is rapamycin.