Preventing over-delivery of drug

• US 10,064,987 B2
• Filed: 01/26/2012
• Issued: 09/04/2018
• Est. Priority Date: 01/31/2011
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Inventors: Wright, Nigel, Monahan, Tom
• Primary Examiner(s): Bosques, Edelmira
• Assistant Examiner(s): Legette-Thompson, Tiffany
• Application Number:
  US13/982,395
• Publication Number:
  US 20140039447A1
• Time in Patent Office: 2,413 Days
• Field of Search: 604500, 604411, 604 67
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 5/14232 Roller pumps
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/1684 by detecting the amount of infusate remaining, e.g. signalling end of infusion
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/365 Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 20/40 relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• CPC Class Codes: G16H 40/63 for local operation

Abstract

This disclosure relates to preventing over-delivery of a drug and related systems and methods. The method includes receiving, from a drug delivery device, information pertaining to a desired amount of fluid to be delivered by the drug delivery device and receiving information pertaining to a delivered amount of a fluid that has been delivered by the drug delivery device. The method also includes determining that the delivered amount satisfies a predetermined threshold amount and in response to the determination, detecting whether an initial amount of fluid provided to the drug delivery device corresponds to the desired amount of fluid to be delivered.

Claims

1. A method performed by a data processing apparatus, the method comprising:

receiving at the data processing apparatus, from a drug delivery device that is part of a dialysis machine, information pertaining to a desired amount of fluid to be delivered by the drug delivery device;

receiving at the data processing apparatus, from a pump, information pertaining to an amount of a fluid that has been delivered by the drug delivery device from a drug vial having an initial amount of fluid provided to the drug delivery device;

determining that the amount delivered by the pump has reached a predetermined threshold amount, the threshold amount being less than the desired amount;

in response to the determination that the threshold amount has been delivered, detecting, by a signal from a bubble detector, a presence or absence of air in a drug delivery line of the drug delivery device indicating whether delivery of the threshold amount has emptied the drug vial, and thereby determining whether the initial amount of fluid in the drug vial approximately equals the desired amount of fluid; and

upon determination of the presence of air in the drug delivery line, automatically sending a signal to the pump via a control unit of the drug delivery device to increase a pumping speed of the pump, and upon determination of the absence of air in the drug delivery line, automatically sending a signal to the pump via the control unit to stop pumping fluid, wherein the signal to stop pumping fluid indicates a determination that the delivered amount of fluid satisfies the desired amount of fluid to be delivered.

2. The method of claim 1, further comprising:

sending an alert to a user interface that the desired amount of fluid does not approximately equal the initial amount of fluid provided.

3. The method of claim 1, wherein detecting the initial amount of fluid further comprises detecting the presence of air for a threshold amount of time.

4. The method of claim 1, wherein the threshold amount is a portion of the initial amount of fluid.

5. A dialysis system comprising:

a dialysis machine;

a control unit comprising one or more processors;

a drug delivery line connected to the dialysis machine;

a bubble detector; and

a computer-readable medium coupled to the control unit having instructions stored thereon which, when executed by the one or more processors, cause the one or more processors to perform operations comprising;

receiving, from a drug delivery device that is part of the dialysis machine, information pertaining to a desired amount of fluid to be delivered by the drug delivery device;

receiving, from a pump, information pertaining to an amount of a fluid that has been delivered by the drug delivery device from a drug vial having an initial amount of fluid provided to the drug delivery device;

determining that the amount delivered by the pump has reached a predetermined threshold amount, the threshold amount being less than the desired amount;

in response to the determination that the threshold amount has been delivered, detecting, by a signal from the bubble detector, a presence or absence of air in the drug delivery line of the drug delivery device indicating whether delivery of the threshold amount has emptied the drug vial, and thereby determining whether the initial amount of fluid in the drug vial approximately equals the desired amount of fluid; and

upon determination of the presence of air in the drug delivery line, automatically sending a signal to the pump via a control unit of the drug delivery device to increase a pumping speed of the pump, and upon determination of the absence of air in the drug delivery line, automatically sending a signal to the pump via the control unit to stop pumping fluid, wherein the signal to stop pumping fluid indicates a determination that the delivered amount of fluid satisfies the desired amount of fluid to be delivered.

6. The system of claim 5, further comprising:

sending an alert to a user interface that the desired amount of fluid does not approximately equal the initial amount of fluid provided.

7. The system of claim 5, wherein detecting the initial amount of fluid further comprises detecting the presence of air for a threshold amount of time.

8. The system of claim 5, wherein the threshold amount is a portion of the initial amount of fluid.