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Systems and methods for reducing or preventing backflow in a delivery system

  • US 10,065,016 B2
  • Filed: 01/21/2015
  • Issued: 09/04/2018
  • Est. Priority Date: 12/18/2012
  • Status: Active Grant
First Claim
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1. A method of delivering a therapeutic agent to a patient, comprising:

  • advancing a convection-enhanced delivery device comprising a distal portion with a first diameter, an intermediate portion with a second diameter that is greater than the first diameter, a proximal portion with a third diameter that is greater than the second diameter, and a fluid lumen extending through the distal, intermediate, and proximal portions into tissue to compress tissue against a distal-facing surface of the intermediate portion and a distal-facing surface of the proximal portion, wherein the distal-facing surfaces of the intermediate and proximal portions are perpendicular to a central axis of the delivery device;

    delivering fluid containing the therapeutic agent under positive pressure through the fluid lumen and into a portion of tissue adjacent to a distal end of the fluid lumen;

    wherein the delivery device includes a first tissue receiving space located adjacent to the distal-facing surface of the intermediate portion into which tissue is compressed during advancement of the delivery device; and

    wherein the delivery device includes a second tissue receiving space into which tissue is compressed during advancement of the delivery device, the second tissue receiving space being located adjacent to the distal-facing surface of the proximal portion.

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