Systems and methods for reducing or preventing backflow in a delivery system
First Claim
1. A method of delivering a therapeutic agent to a patient, comprising:
- advancing a convection-enhanced delivery device comprising a distal portion with a first diameter, an intermediate portion with a second diameter that is greater than the first diameter, a proximal portion with a third diameter that is greater than the second diameter, and a fluid lumen extending through the distal, intermediate, and proximal portions into tissue to compress tissue against a distal-facing surface of the intermediate portion and a distal-facing surface of the proximal portion, wherein the distal-facing surfaces of the intermediate and proximal portions are perpendicular to a central axis of the delivery device;
delivering fluid containing the therapeutic agent under positive pressure through the fluid lumen and into a portion of tissue adjacent to a distal end of the fluid lumen;
wherein the delivery device includes a first tissue receiving space located adjacent to the distal-facing surface of the intermediate portion into which tissue is compressed during advancement of the delivery device; and
wherein the delivery device includes a second tissue receiving space into which tissue is compressed during advancement of the delivery device, the second tissue receiving space being located adjacent to the distal-facing surface of the proximal portion.
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Accused Products
Abstract
Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.
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Citations
6 Claims
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1. A method of delivering a therapeutic agent to a patient, comprising:
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advancing a convection-enhanced delivery device comprising a distal portion with a first diameter, an intermediate portion with a second diameter that is greater than the first diameter, a proximal portion with a third diameter that is greater than the second diameter, and a fluid lumen extending through the distal, intermediate, and proximal portions into tissue to compress tissue against a distal-facing surface of the intermediate portion and a distal-facing surface of the proximal portion, wherein the distal-facing surfaces of the intermediate and proximal portions are perpendicular to a central axis of the delivery device; delivering fluid containing the therapeutic agent under positive pressure through the fluid lumen and into a portion of tissue adjacent to a distal end of the fluid lumen; wherein the delivery device includes a first tissue receiving space located adjacent to the distal-facing surface of the intermediate portion into which tissue is compressed during advancement of the delivery device; and wherein the delivery device includes a second tissue receiving space into which tissue is compressed during advancement of the delivery device, the second tissue receiving space being located adjacent to the distal-facing surface of the proximal portion. - View Dependent Claims (2, 3, 4, 5)
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6. A method of delivering a therapeutic agent to a patient, comprising:
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advancing a convection-enhanced delivery device comprising a distal cylindrical portion with a first diameter, an intermediate cylindrical portion with a second diameter that is greater than the first diameter, a proximal cylindrical portion with a third diameter that is greater than the second diameter, and a fluid lumen extending through the distal, intermediate, and proximal portions into tissue to compress tissue against a distal-facing surface of the intermediate portion and a distal-facing surface of the proximal portion; delivering fluid containing the therapeutic agent under positive pressure through the fluid lumen and into a portion of tissue adjacent to a distal end of the fluid lumen; wherein the delivery device includes a first tissue receiving space located adjacent to the distal-facing surface of the intermediate portion into which tissue is compressed during advancement of the delivery device; and wherein the delivery device includes a second tissue receiving space into which tissue is compressed during advancement of the delivery device, the second tissue receiving space being located adjacent to the distal-facing surface of the proximal portion.
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Specification