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Apparatus and method for promoting angiogenesis in ischemic tissue

  • US 10,065,018 B2
  • Filed: 09/16/2016
  • Issued: 09/04/2018
  • Est. Priority Date: 03/16/2016
  • Status: Expired due to Fees
First Claim
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1. A method of promoting angiogenesis in an ischemic area of a patient body, comprising:

  • accessing a subintimal space between an adventitial layer and an intimal layer of a vascular wall of an occluded blood vessel, the subintimal space having a surface;

    providing a biologics delivery device comprising a catheter having a proximal end, a distal region having a distal end, a side wall defining a catheter lumen, an expandable member configured to transition between a collapsed state and an expanded state, and a retractably deployable hollow needle within the catheter lumen, the hollow needle having a penetration tip and a biologics delivery lumen extending therethrough;

    introducing the distal end of the biologics delivery device into the subintimal space;

    transitioning the expandable member positioned in the subintimal space to an expanded state to contact and support the surface of the subintimal space;

    deploying the penetration tip of the needle from inside the catheter lumen to outside the catheter lumen, through the expandable member, and into tissue surrounding the occluded blood vessel; and

    delivering a biologic through the biologics delivery lumen to the tissue.

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