Reducing optical interference in a fluidic device
First Claim
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1. A system for detecting an analyte in a sample of bodily fluid, comprising:
- a fluidic device comprising;
a housing comprising;
an assay assembly comprising at least one reagent for generating an optical signal that is indicative of the presence of the analyte, anda quencher assembly in fluidic communication with but separated by a channel from the assay assembly, wherein the quencher assembly comprises an absorbent material and a quenching agent, wherein the quenching agent comprises a singlet oxygen quencher or an organic compound with an absorbance spectrum overlapping a fluorescence emission spectrum of a fluorescent species used to enhance the optical signal; and
a detection assembly comprising an optical detector configured to detect the optical signal.
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Abstract
This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces interference with an optical signal which is indicative of the presence of an analyte in a bodily sample.
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13 Claims
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1. A system for detecting an analyte in a sample of bodily fluid, comprising:
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a fluidic device comprising; a housing comprising; an assay assembly comprising at least one reagent for generating an optical signal that is indicative of the presence of the analyte, and a quencher assembly in fluidic communication with but separated by a channel from the assay assembly, wherein the quencher assembly comprises an absorbent material and a quenching agent, wherein the quenching agent comprises a singlet oxygen quencher or an organic compound with an absorbance spectrum overlapping a fluorescence emission spectrum of a fluorescent species used to enhance the optical signal; and a detection assembly comprising an optical detector configured to detect the optical signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification