Computational systems for biomedical data

• US 10,068,303 B2
• Filed: 06/04/2007
• Issued: 09/04/2018
• Est. Priority Date: 09/29/2006
• Status: Active Grant

• Current Assignee: Travera, LLC
• Original Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Inventors: Jung, Edward K. Y., Levien, Royce A., Lord, Robert W., Malamud, Mark A., Wood, Jr., Lowell L.
• Primary Examiner(s): Lin, Jerry
• Application Number:
  US11/810,358
• Publication Number:
  US 20080081959A1
• Time in Patent Office: 4,110 Days
• Field of Search: 702 19
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/00 ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

Methods, apparatuses, computer program products, devices and systems are described that accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter; determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and presenting the agent, based on the at least one subset and the at least one query parameter.

Claims

1. A method for a study data analysis system, comprising:

accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target;

determining, at least partially based on the accepting at least one input identifying the at least one treatment target in search of the at least one combination therapy including the at least one agent and the at least one supplemental agent, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy;

correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy;

controlling at least one output device to output at least one indication of (a) the at least one combination therapy, the at least one combination therapy including the at least one agent and the at least one supplemental agent exhibiting at least one decreased level of the at least one adverse event relative to the at least one other therapy, (b) the at least one subpopulation, and (c) at least one indication of the increased tolerance level in the at least one subpopulation of the at least one agent at least partially based on the at least one subset of study data and the at least one query parameter; and

initiating at least one intervention, the at least one intervention including administration of at least a portion of the at least one combination therapy including the at least one agent and the at least one supplemental agent,

wherein at least one of accepting, determining, correlating, controlling, or initiating is at least partially implemented using one or more processing devices.

2. A study data analysis system, comprising:

circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target;

circuitry configured for determining, at least partially based on the circuitry configured for accepting at least one input identifying the at least one treatment target in search of the at least one combination therapy including the at least one agent and the at least one supplemental agent, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy;

circuitry configured for correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy;

circuitry configured for controlling at least one output device to output at least one indication of (a) the at least one combination therapy, the at least one combination therapy including the at least one agent and the at least one supplemental agent exhibiting at least one decreased level of the at least one adverse event relative to the at least one other therapy, (b) the at least one subpopulation, and (c) at least one indication of the increased tolerance level in the at least one subpopulation of the at least one agent at least partially based on the at least one subset of study data and the at least one query parameter, and

circuitry configured for initiating at least one intervention, the at least one intervention including administration of at least a portion of the at least one combination therapy including the at least one agent and the at least one supplemental agent.

3. The system of claim 2, wherein circuitry configured for determining, at least partially based on the circuitry configured for accepting at least one input identifying the at least one treatment target in search of the at least one combination therapy including the at least one agent and the at least one supplemental agent, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises:

circuitry configured for determining at least one of a genomic subset, a proteomic subset, an hepatic enzyme profile subset, an RNA expression subset, a biochemical subset, a nutritional supplementation subset, a lifestyle subset, a medical history subset, an ethnic subset, an age-based subset, or a gender-based subset as the at least one subset of study data in association with at least one recommended combination therapy including at least one immunotherapy for cancer.

4. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry configured for accepting at least one user input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one user input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target.

5. The system of claim 2, wherein circuitry configured for controlling at least one output device to output at least one indication of (a) the at least one combination therapy, the at least one combination therapy including the at least one agent and the at least one supplemental agent exhibiting at least one decreased level of the at least one adverse event relative to the at least one other therapy, (b) the at least one subpopulation, and (c) at least one indication of the increased tolerance level in the at least one subpopulation of the at least one agent at least partially based on the at least one subset of study data and the at least one query parameter comprises:

circuitry configured for displaying the at least one indication of (a) the at least one combination therapy, the at least one combination therapy including the at least one agent and the at least one supplemental agent exhibiting at least one decreased level of the at least one adverse event relative to the at least one other therapy, (b) the at least one subpopulation, and (c) at least one indication of the increased tolerance level in the at least one subpopulation of the at least one agent at least partially based on the at least one subset of study data and the at least one query parameter via at least one user interface of the at least one output device.

6. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least one of a medical condition, a medical indication, a disease stage, a patient characteristic, a nutritional deficiency, an obesity condition, a chronic condition, or an acute condition as the at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent.

7. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least one of an adverse event, an adverse event incidence value, an adverse event rate, a measure of adverse event severity, an effectiveness value, or an effectiveness rate associated with at least one chemotherapeutic therapy as the at least one query parameter.

8. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least one of a genomic dataset, a proteomic dataset, a biochemical dataset, or a population dataset as the at least one query parameter.

9. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least one measure of at least one checkpoint inhibitor associated with at least one immunotherapy as the at least one query parameter.

10. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least one qualitative limit on one or more adverse events as the at least one query parameter.

11. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least one maximum mean incidence of one or more adverse events as the at least one query parameter.

12. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least a maximum adverse event limit and a minimum efficacy limit as the at least one query parameter.

13. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least one input associated with one or more statistical filters as the at least one query parameter.

14. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry for accepting at least one input associated with a standard deviation statistical filter, a mean value statistical filter, a confidence interval statistical filter, an AN OVA statistical filter, or a p-value statistical filter as the at least one query parameter.

15. The system of claim 2, wherein circuitry configured for determining, at least partially based on the circuitry configured for accepting at least one input identifying the at least one treatment target in search of the at least one combination therapy including the at least one agent and the at least one supplemental agent, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises:

circuitry configured for determining at least one of a genomic subset, a proteomic subset, an hepatic enzyme profile subset, an RNA expression subset, a biochemical subset, a nutritional supplementation subset, a lifestyle subset, a medical history subset, an ethnic subset, an age-based subset, or a gender-based subset as the at least one subset of study data in association with at least one recommended combination therapy including at least one microbiome therapy.

16. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter including at least one specified adverse event and at least one specified level of incidence of the at least one specified adverse event, and

wherein circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises;

circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data for which at least one adverse event profile associated with administration of the at least one combination therapy including at least one agent and at least one supplemental agent is acceptable relative to the at least one specified level of incidence of the at least one specified adverse event.

17. The system of claim 2, wherein circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises:

circuitry configured for determining at least one prescription medication associated with at least one of maintaining or increasing efficacy with respect to the at least one treatment target as the at least one agent;

circuitry configured for determining at least one supplemental agent known to improve tolerance of the at least one prescription medication in at least one subpopulation; and

circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data for which at least one adverse event profile associated with administration of the at least one prescription medication is acceptable within at least one defined limit for the at least one subpopulation when the at least one prescription medication is supplemented with the at least one supplemental agent relative to at least one population for which the at least one adverse event profile is unacceptable with respect to the at least one defined limit.

18. The system of claim 2, wherein circuitry configured for correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy comprises:

circuitry configured for correlating the at least one subset of study data with one or more of at least some age data, at least some gender data, at least some ethnicity data, at least some race data, at least some genotype data, or at least some medical history data as the at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation associated by the one or more of at least some age data, at least some gender data, at least some ethnicity data, at least some race data, at least some genotype data, or at least some medical history data as possible beneficiaries of treatment with the at least one agent.

19. The system of claim 2, wherein circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises:

circuitry configured for searching at least one dataset and extracting from the at least one dataset at least one subset of study data in response to the at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent and the at least one query parameter, the at least one subset including at least one subpopulation for which at least one adverse event profile associated with administration of at least one combination therapy including at least one agent and at least one supplemental agent is acceptable within at least one defined limit relative to at least one population for which the at least one adverse event profile is unacceptable with respect to the at least one defined limit.

20. The system of claim 2, wherein circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises:

circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one adverse event profile associated with administration of the at least one combination therapy including at least one agent and at least one supplemental agent is acceptable within at least one defined limit relative to at least one clinical trial population for which the at least one adverse event profile is unacceptable with respect to the at least one defined limit.

21. The system of claim 2, wherein circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises:

circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one adverse event profile associated with administration of the at least one combination therapy including at least one agent and at least one supplemental agent is less than or equal to the at least one defined limit.

22. The system of claim 2, wherein circuitry configured for correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy comprises:

circuitry configured for correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy including at least one agent and at least one supplemental agent at least partially based on the at least one query parameter, the at least one query parameter indicative of at least one database to search to determine the at least one subpopulation identifier.

23. The system of claim 2, wherein circuitry configured for correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy comprises:

circuitry configured for correlating the at least one subset of study data with at least some subpopulation identifier data at least partially based on at least one indication of a level of efficacy representing an adequately beneficial result of treatment as the at least one query parameter, including at least identifying at least one subpopulation indicated by the at least some subpopulation identifier data associated with experiencing the level of efficacy representing an adequately beneficial result of the administration of the at least one combination therapy including at least one agent and at least one supplemental agent to obtain the at least one indication of the at least one subpopulation indicated by the at least some subpopulation identifier data as possible beneficiaries of treatment with the at least one combination therapy including at least one agent and at least one supplemental agent.

24. The system of claim 2, wherein circuitry configured for correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy comprises:

circuitry configured for correlating the at least one subset of study data with one or more of at least some genetic data, at least some epigenetic data, at least some biochemical data, at least some gene expression data, at least some protein expression data, at least some behavioral data, at least some physiologic data, or at least some demographic data as the at least some subpopulation identifier data to obtain at least one identification of at least one subpopulation associated by the one or more of at least some genetic data, at least some epigenetic data, at least some biochemical data, at least some gene expression data, at least some protein expression data, at least some behavioral data, at least some physiologic data, or at least some demographic data as possible beneficiaries of treatment with the at least one combination therapy including at least one agent and at least one supplemental agent.

25. The system of claim 2, further comprising:

circuitry configured for confirming that the at least one subset of study data associated with at least one recommended combination therapy corresponds to efficacy upon administration of the at least one combination therapy including at least one agent and at least one supplemental agent by referring to at least some subpopulation efficacy data.

26. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry configured for receiving at least one transmission identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter.

27. The system of claim 2, wherein circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises:

circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one adverse event profile associated with administration of the at least one combination therapy including at least one agent and at least one supplemental agent is acceptable within at least one defined limit relative to at least one population for which the at least one adverse event profile is unacceptable with respect a different defined limit.

28. The system of claim 2, wherein circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy comprises:

circuitry configured for determining, at least partially based on the at least one input, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one level of efficacy of at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy.

29. The system of claim 2, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target comprises:

circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent which, when administered individually, does not exhibit a desired efficacy in treatment of the at least one treatment target and which, when supplemented with the at least one supplemental agent, exhibits a desired efficacy in treatment of the at least one treatment target.

30. The system of claim 29, wherein circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent which, when administered individually, does not exhibit a desired efficacy in treatment of the at least one treatment target and which, when supplemented with the at least one supplemental agent, exhibits a desired efficacy in treatment of the at least one treatment target comprises:

circuitry configured for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent for replacement of at least another agent which exhibits a desired efficacy in treatment of the at least one treatment target but also exhibits an unacceptable level of adverse events when used in treatment of the at least one treatment target.

31. A computer program product for a study data analysis system, comprising:

at least one non-transitory computer-readable medium including at least;

one or more instructions for accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target;

one or more instructions for determining, at least partially based on the one or more instructions for accepting at least one input identifying the at least one treatment target in search of the at least one combination therapy including the at least one agent and the at least one supplemental agent, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy;

one or more instructions for correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy;

one or more instructions for controlling at least one output device to output at least one indication of (a) the at least one combination therapy, the at least one combination therapy including the at least one agent and the at least one supplemental agent exhibiting at least one decreased level of the at least one adverse event relative to the at least one other therapy, (b) the at least one subpopulation, and (c) at least one indication of the increased tolerance level in the at least one subpopulation of the at least one agent at least partially based on the at least one subset of study data and the at least one query parameter; and

one or more instructions for initiating at least one intervention, the at least one intervention including administration of at least a portion of the at least one combination therapy including the at least one agent and the at least one supplemental agent.

32. A study data analysis system, comprising:

a computing device; and

one or more instructions which, when executed by the computing device, cause the computing device to perform one or more operations including at least;

accepting at least one input identifying at least one treatment target in search of at least one combination therapy including at least one agent and at least one supplemental agent, the at least one input associated with at least one query parameter, the at least one query parameter indicative of at least one acceptable level of adverse events associated with administration of the at least one combination therapy in treatment of the at least one treatment target;

determining, at least partially based on the accepting at least one input identifying the at least one treatment target in search of the at least one combination therapy including the at least one agent and the at least one supplemental agent, at least one subset of study data associated with at least one recommended combination therapy for which at least one level of adverse events associated with administration of the at least one combination therapy is acceptable within at least one subpopulation at least partially based on the at least one query parameter, the at least one recommended combination therapy associated with at least one level of efficacy equal or superior to at least one other therapy which, when administered within the at least one subpopulation, exhibits at least one adverse event profile that is unacceptable with respect to the at least one query parameter, the at least one agent of the at least one combination therapy associated with at least one increased tolerance level among the at least one subpopulation relative to the at least one other therapy and dependent upon the at least one supplemental agent for increasing the at least one level of efficacy of;

the at least one combination therapy beyond the at least one level of efficacy of the at least one other therapy;

correlating the at least one subset of study data with at least some subpopulation identifier data to obtain at least one identification of the at least one subpopulation as possible beneficiaries of treatment with the at least one combination therapy;

controlling at least one output device to output at least one indication of (a) the at least one combination therapy, the at least one combination therapy including the at least one agent and the at least one supplemental agent exhibiting at least one decreased level of the at least one adverse event relative to the at least one other therapy, (b) the at least one subpopulation, and (c) at least one indication of the increased tolerance level in the at least one subpopulation of the at least one agent at least partially based on the at least one subset of study data and the at least one query parameter; and

initiating at least one intervention, the at least one intervention including administration of at least a portion of the at least one combination therapy including the at least one agent and the at least one supplemental agent.