Impedance measurement process

• US 10,070,800 B2
• Filed: 12/08/2015
• Issued: 09/11/2018
• Est. Priority Date: 08/09/2007
• Status: Active Grant

• Current Assignee: ImpediMed Limited
• Original Assignee: ImpediMed Limited
• Inventors: Cornish, Bruce Herbert, Thomas, Brian John, Smith, Jye Geoffrey
• Primary Examiner(s): CERIONI, DANIEL LEE
• Application Number:
  US14/963,018
• Publication Number:
  US 20160089051A1
• Time in Patent Office: 1,008 Days
• Field of Search: 600547
• CPC Class Codes: A61B 2562/0214 Capacitive electrodes
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/4331 of the cervix A61B5/435 takes precedence
• CPC Class Codes: A61B 5/444 Evaluating skin marks, e.g. mole, nevi, tumour, scar
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence

Abstract

A method for use in performing impedance measurements on a subject. The method includes, in a processing system, determining at least one first impedance value, measured at a site using a first electrode configuration, determining at least one second impedance value, measured at the site using a second electrode configuration, and determining the presence, absence or degree of an anomaly using the first and second impedance values.

Claims

1. Apparatus for use in performing impedance measurements on a subject, the apparatus comprising:

a) an electrode array having a number of electrodes configured to form a rectangular array;

b) a signal generator for generating signals to be applied to the subject using drive electrodes of the array;

c) a sensor for determining measured signals induced across the subject using measurement electrodes of the array;

d) a switching device coupled to the electrode array; and

,

e) a processing system that controls the switching device to selectively interconnect the signal generator and the sensor to the selected ones of the electrodes, which therefore function as drive and measurement electrodes, the processing system configured to control the switching device to;

cause a first measurement to be performed at a first site using first and second electrodes as drive electrodes and using third and fourth electrodes as measurement electrodes;

cause a second measurement to be performed at the first site using first and third electrodes as drive electrodes and using second and fourth electrodes as measurement electrodes;

determine a presence, absence or degree of an anomaly at the first site using the first and second measurements;

cause a third measurement to be performed at a second site using third and fifth electrodes as drive electrodes and using fourth and sixth electrodes as measurement electrodes;

cause a fourth measurement to be performed at the second site using third and fourth electrodes as drive electrodes and using fifth and sixth electrodes as measurement electrodes; and

determine a presence, absence or degree of an anomaly at the second site using the third and fourth measurements.

2. The apparatus according to claim 1, wherein the switching device is a multiplexer.

3. The apparatus according to claim 1, wherein the electrodes in the electrode array are configured to form a square grid.

4. The apparatus according to claim 1, wherein the electrodes have a diameter of approximately 1 mm.

5. The apparatus according to claim 1, wherein the electrode array is configured to form at least one of:

a) a 2×

2 array;

b) a 2×

4 array; and

,

c) a 5×

5 array.

6. The apparatus according to claim 1, wherein a spacing between adjacent electrodes is at least one of:

a) less than the diameter of the electrodes;

b) fixed; and

,

c) approximately 0.77 mm.

7. The apparatus according to claim 1, wherein the processing system includes a processor, a memory, an input/output device and an external interface coupled together via a bus.

8. The apparatus according to claim 1, wherein the processing system is an FPGA.

9. The apparatus according to claim 1, wherein the processing system:

a) determines a first impedance value, measured at a site using a first tetrapolar electrode configuration of drive and measurement electrodes selected from the array;

b) causes at least one of the drive electrodes to become a measurement electrode and at least one of the measurement electrodes to become a drive electrode to thereby define a second tetrapolar electrode configuration by controlling the switching device;

c) determines a second impedance value, measured at the site using the second electrode configuration

d) determines a difference between the first and second impedance values; and

,

e) determines a presence, absence or degree of an anomaly using the determined difference.

10. The apparatus according to claim 1, wherein the processing system:

a) controls the signal generator to apply one or more drive signals to the subject; and

,

b) receives an indication of the measured signals measured using the sensor.

11. The apparatus according to claim 1, wherein the processing system:

a) receives an indication of drive signals applied to the subject;

b) receives an indication of measured signals determined using the sensor; and

,

c) uses the indications to determine an impedance.

12. The apparatus according to claim 1, wherein the processing system controls the switching device to:

a) cause a first measurement to be performed at the site using first and second electrodes as drive electrodes and using third and fourth electrodes as measurement electrodes; and

,

b) cause a second measurement to be performed at the site using first and third electrodes as drive electrodes and using second and fourth electrodes as measurement electrodes.

13. The apparatus according to claim 1, wherein the processing system controls the switching device to:

a) cause a measurement to be performed at a site using first and second electrodes as drive electrodes and using third and fourth electrodes as measurement electrodes; and

,

b) cause a measurement to be performed at a second site using at least two of the first, second, third and fourth electrodes.

14. The apparatus according to claim 1, wherein the processing system forms part of a measuring device for performing impedance measurements.

15. The apparatus according to claim 9, wherein the processing system:

a) determines impedance values at a number of different sites; and

,

b) determines an impedance map using the impedance values at each site.

16. The apparatus according to claim 15, wherein the processing system selects a different site by controlling the switching device to interconnect the signal generator and sensor to a different combination of four electrodes than used to perform impedance measurements at a previous site.

17. The apparatus according to claim 15, wherein the processing system:

a) determines the presence of an anomaly at any one of the sites; and

,

b) determines the impedance map taking the anomaly into account.

18. The apparatus according to claim 17, wherein the processing system, for any site having an anomaly, at least one of:

a) excludes the site from the impedance map;

b) modifies the impedance value determined for the site.

19. The apparatus according to claim 18, wherein fluid levels in a region of the body are able to be determined from the impedance map taking into account any erroneous measurements caused by the anomaly.

20. The apparatus according to claim 9, wherein the processing system:

a) determines a difference between the first and second impedance values;

b) compares the difference to a reference; and

,

c) determines an anomaly depending on the result of the comparison.

21. The apparatus according to claim 20, wherein the reference is a previously measured difference value for the subject.