Integrated cancer therapy—imaging apparatus and method of use thereof

• US 10,070,831 B2
• Filed: 06/14/2016
• Issued: 09/11/2018
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: ProTom International Holding Corporation
• Original Assignee: ProTom International Holding Corporation
• Inventors: Bennett, James P., Spotts, Stephen L., Lee, W. Davis, Michaud, Susan L.
• Primary Examiner(s): NGUYEN, KIET TUAN
• Application Number:
  US15/182,507
• Publication Number:
  US 20160287908A1
• Time in Patent Office: 819 Days
• Field of Search: 2504923
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4014 arranged in multiple source-detector units
• CPC Class Codes: A61B 6/4085 Cone-beams
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/487 involving fluoroscopy
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: A61N 2005/105 using a laser alignment system
• CPC Class Codes: A61N 2005/1054 using a portal imaging system
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1044 with multiple repetitions of the scanning pattern
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1069 Target adjustment, e.g. moving the patient support
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/08 Deviation, concentration or focusing of the beam by electric or magnetic means electron-optical arrangements in electric discharge tubes H01J29/46; details, e.g. electric or magnetic deviating means for direct voltage accelerators or in accelerators using single pulses H05H5/02; arrangements for injecting particles into orbits H05H7/08; arrangements for ejecting particles from orbits H05H7/10
• CPC Class Codes: G21K 5/04 with beam-forming means

Abstract

The invention comprises a positively charged particle based cancer therapy system integrated with at least one off-axis imaging system, where elements of the off-axis imaging system and the cancer therapy system are co-positioned/co-rotated with a gantry. The imaging apparatus optionally functions with a tomography system using the positively charged particles of the cancer therapy system for enhanced patient/tumor imaging at and/or prior to a time of treatment.

Claims

1. An apparatus for imaging a tumor of a patient with positively charged particles, comprising:

a beam transport system configured to transport the positively charged particles from a synchrotron to at least the tumor of the patient along a treatment beam path;

a first imaging system comprising a first imaging beam path from a gantry to the tumor; and

a second imaging system comprising a second imaging beam path from said gantry to the tumor, said first imaging beam path, a rotation point about which the gantry rotates, and the second imaging beam path forming an angle of greater than fifty degrees,

said gantry configured to physically support a set of elements comprising;

(1) at least a portion of said beam transport system, (2) at least a portion of said first imaging system, and (3) at least a portion of said second imaging system.

2. The apparatus of claim 1, said first imaging system comprising a first X-ray imaging system, said second imaging system comprising a second X-ray system.

3. The apparatus of claim 2, said gantry further comprising:

an arc, said gantry configured to co-move said set of elements along said arc.

4. The apparatus of claim 3, said first X-ray imaging system comprising a first cone beam X-ray element, said second X-ray imaging system comprising a second cone beam X-ray element.

5. The apparatus of claim 4, said first X-ray imaging system and said second X-ray imaging system combining to form at least one cone beam computed tomography X-ray system.

6. The apparatus of claim 4, said first imaging system further comprising:

a first two-dimensional detection surface mounted opposite the rotation point from a center of a connection point of said at least a portion of said first imaging system to said gantry.

7. The apparatus of claim 1, said first imaging system comprising an element of a two-dimensional cone beam computed tomography X-ray system.

8. The apparatus of claim 7, said second imaging system comprising a fluoroscopy system.

9. A method for imaging a tumor of a patient with positively charged particles, comprising the steps of:

transporting the positively charged particles, using a beam transport system, from a synchrotron to at least the tumor of the patient along a treatment beam path;

functioning a first imaging system along a first imaging beam path from a gantry to the tumor; and

operating a second imaging system along a second imaging beam path from said gantry to the tumor, said first imaging beam path, the tumor, and said second imaging beam path forming an angle of greater than sixty degrees,

wherein said gantry physically supports a set of elements comprising;

(1) at least a portion of said beam transport system, (2) at least a portion of said first imaging system, and (3) at least a portion of said second imaging system.

10. The method of claim 9, further comprising the step of:

rotating said gantry about a rotation point, said step of rotating further comprising the step of;

moving said set of elements along a first arc.

11. The method of claim 10, further comprising the steps of:

imaging the tumor using both said first imaging system and said second imaging system to form an image; and

treating the tumor with the positively charged particles using the image.

12. The method of claim 11, further comprising the step of:

controlling both said step of imaging and said step of treating with a portable control pendant positioned in view of said gantry and outside of a treatment room housing said gantry.

13. The method of claim 11, further comprising the step of:

generating a tomographic image from a detected signal resultant from the positively charged particles after the positively charged particles transit through said tumor; and

said step of treating the tumor further comprising the step of using the tomographic image in targeting the tumor.

14. The method of claim 13, further comprising the steps of:

positioning a first light emitting material in a plane across the treatment beam path between an exit nozzle of said beam transport system and the tumor;

detecting photons emitted from said light emitting material upon transmission of the positively charged particles through said first light emitting material; and

determining a path of the positively charged particles using both the photons and said tomographic image.

15. The method of claim 9, said first imaging system further comprising a cone beam computed tomography X-ray based imaging system.

16. The method of claim 15, further comprising the step of:

co-rotating;

(1) a first source element and a first detector of said first imaging system and (2) a second source element and a second detector of said second imaging system.

17. The method of claim 16, further comprising the step of:

tomographically imaging the tumor to form a tomographic image using the positively charged particles.

18. The method of claim 17, further comprising the step of:

implementing a cancer treatment therapy plan using both a first image generated using said cone beam computed tomography X-ray based imaging system and said tomographic image.

19. The method of claim 18, further comprising the steps of:

said gantry physically supporting a third imaging system, said third imaging system not using X-rays or the positively charged particles; and

generating a tumor image using said third imaging system.

20. The method of claim 9 further comprising the steps of:

rotating the patient with a patient positioning system;

generating a cone beam computed tomography image of the tumor without rotation of the gantry; and

treating the tumor of the patient, using the cone beam computed tomography image, with the positively charged particles.