Compact hydraulic manifold structure for shear sensitive fluids
First Claim
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1. A microfluidic device for processing blood comprising:
- a first network of channels having a plurality of First Channels, each First Channel having a height in the range of about 50 microns to about 500 microns;
a second network of channels having at least one Second Channel complementary to one or more of the First Channels;
wherein the plurality of First Channels further comprises;
an input channel forming a primary channel, a plurality of secondary channels, and an outlet channel whereina width of the primary channel varies along the length of the primary channel such that an angle formed by a centerline of the primary channel and a wall of the primary channel is greater than zero degrees and less than or equal to about 45 degrees;
a first secondary channel connects to the primary channel at a first junction located at a first distance from a first end of the primary channel;
a second secondary channel connects to the primary channel at a second junction located at a second distance, greater than the first distance, from the first end of the primary channel;
at least one of the first and second secondary channels includes a curved portion directing flow away from the primary channel, the curved portion having a radius of curvature that is not less than its hydraulic diameter; and
at least one of the first and second secondary channels bifurcates into first and second tertiary channels at a third junction.
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Abstract
A compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
26 Citations
8 Claims
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1. A microfluidic device for processing blood comprising:
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a first network of channels having a plurality of First Channels, each First Channel having a height in the range of about 50 microns to about 500 microns; a second network of channels having at least one Second Channel complementary to one or more of the First Channels; wherein the plurality of First Channels further comprises; an input channel forming a primary channel, a plurality of secondary channels, and an outlet channel wherein a width of the primary channel varies along the length of the primary channel such that an angle formed by a centerline of the primary channel and a wall of the primary channel is greater than zero degrees and less than or equal to about 45 degrees; a first secondary channel connects to the primary channel at a first junction located at a first distance from a first end of the primary channel; a second secondary channel connects to the primary channel at a second junction located at a second distance, greater than the first distance, from the first end of the primary channel; at least one of the first and second secondary channels includes a curved portion directing flow away from the primary channel, the curved portion having a radius of curvature that is not less than its hydraulic diameter; and at least one of the first and second secondary channels bifurcates into first and second tertiary channels at a third junction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification