Reperfusion protection in resuscitation
First Claim
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1. A medical system comprising:
- at least one sensor configured to perform near infrared spectroscopy (NIRS), and to generate a signal representing a pH of tissues of a patient; and
a processor communicably coupled to the at least one sensor, the processor configured to;
receive the signal; and
generate an instruction configured to result in a ventilator adjusting a partial pressure of CO2 in a gas mixture delivered to the patient to one or more partial pressures high enough to slow expiration of CO2 from the patient'"'"'s lungs and thereby maintain an increased PCO2 in tissues of the patient for a period of time following return of spontaneous circulation (ROSC),wherein the instruction is configured to result in the ventilator adjusting the partial pressure of the CO2 in the gas mixture so as to maintain the pH at a constant level for a first portion of the period of time following ROSC.
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Abstract
An apparatus and method for resuscitating a patient suffering from cardiac arrest or another condition in which normal circulation has been interrupted. A ventilator is used for delivering a gas mixture to the patient. The ventilator is configured to adjust the partial pressure of CO2 to one or more partial pressures high enough to slow expiration of CO2 from the patient'"'"'s lungs and thereby maintain a reduced pH in the patient'"'"'s tissues for a period of time following return of spontaneous circulation.
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Citations
22 Claims
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1. A medical system comprising:
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at least one sensor configured to perform near infrared spectroscopy (NIRS), and to generate a signal representing a pH of tissues of a patient; and a processor communicably coupled to the at least one sensor, the processor configured to; receive the signal; and generate an instruction configured to result in a ventilator adjusting a partial pressure of CO2 in a gas mixture delivered to the patient to one or more partial pressures high enough to slow expiration of CO2 from the patient'"'"'s lungs and thereby maintain an increased PCO2 in tissues of the patient for a period of time following return of spontaneous circulation (ROSC), wherein the instruction is configured to result in the ventilator adjusting the partial pressure of the CO2 in the gas mixture so as to maintain the pH at a constant level for a first portion of the period of time following ROSC. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of resuscitating a patient suffering from cardiac arrest or another condition in which normal circulation has been interrupted, the method comprising:
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determining, using near infrared spectroscopy (NIRS), a pH of tissues of the patient; and delivering, using a ventilator, a gas mixture to the patient, adjusting, by the ventilator, a partial pressure of CO2 in the gas mixture to one or more partial pressures high enough to slow expiration of CO2 from the patient'"'"'s lungs and thereby maintain an increased tissue PCO2 for a period of time following return of spontaneous circulation (ROSC), wherein the adjusting the partial pressure by the ventilator comprises adjusting the partial pressure of the CO2 in the gas mixture so as to maintain the pH at a constant level for a first portion of the period of time following ROSC. - View Dependent Claims (17, 18, 19, 20, 21, 22)
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Specification