Light therapy treatment

• US 10,071,261 B2
• Filed: 05/12/2015
• Issued: 09/11/2018
• Est. Priority Date: 05/01/2009
• Status: Active Grant

• Current Assignee: Wayne State University
• Original Assignee: Wayne State University
• Inventors: Huttemann, Maik, Sanderson, Thomas, Kamholz, John, Nantwi, Kwaku, Przyklenk, Karin, Lee, Icksoo, Grossman, Lawrence
• Primary Examiner(s): Van Roy, Tod T
• Application Number:
  US14/709,869
• Publication Number:
  US 20150246240A1
• Time in Patent Office: 1,218 Days
• Field of Search: 606 2, 606 3, 607 88, 607 89
• CPC Class Codes: A61N 2005/0626 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0643 Applicators, probes irradiating specific body areas in close proximity
• CPC Class Codes: A61N 2005/0647 the applicator adapted to be worn on the head
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/06 using light
• CPC Class Codes: A61N 5/0613 Apparatus adapted for a specific treatment

Abstract

A light therapy method, comprising identifying a pathological condition in a patient, selecting at least one light wavelength based on the identified pathological condition, and applying one or a combination of the selected light wavelengths to the patient using a light source.

Claims

1. A light therapy method, comprising:

identifying a condition in a tissue of a patient that causes an ischemic event to occur in the tissue;

selecting at least one light wavelength based on the identified condition; and

applying one or a combination of the selected light wavelengths to the patient as an amount of light using a light source;

wherein the step of applying one or a combination of the selected light wavelengths occurs during an onset of reoxygenation of the tissue; and

wherein applying the one or the combination of the selected light wavelengths begins prior to the onset of reoxygenation of the tissue.

2. The method of claim 1, wherein:

identifying the condition comprises identifying neonatal hypoxia; and

applying the one or the combination of the selected light wavelengths comprises applying to a scalp of the patient using the light source.

3. The method of claim 2, wherein applying the one or the combination of the selected light wavelengths further comprises applying the one or the combination of the selected light wavelengths that includes one of approximately 750 nm and approximately 950 nm.

4. The method of claim 3, further comprising applying up to approximately 5 W/cm² of infrared light power.

5. The method of claim 1, wherein:

identifying the condition comprises identifying a pathological condition that includes multiple sclerosis; and

applying the one or the combination of the selected light wavelengths comprises applying to one of the head and spinal cord.

6. The method of claim 5, wherein applying the one or the combination of the selected light wavelengths further comprises applying the one or the combination of the selected light wavelengths that includes one of approximately 870 nm and approximately 950 nm.

7. The method of claim 6, further comprising applying up to approximately 5 W/cm² of infrared light power output.

8. The method of claim 1, wherein:

identifying the condition comprises identifying a pathological condition that includes a spinal cord injury; and

applying the one or the combination of the selected light wavelengths comprises applying to the spinal cord.

9. The method of claim 8, wherein applying the one or the combination of the selected light wavelengths further comprises applying the one or the combination of the selected light wavelengths that includes approximately 870 nm.

10. The method of claim 9, further comprising applying up to approximately 5 W/cm² of infrared power.

11. The method of claim 1, wherein the light source comprises lights having wavelengths that fall within ranges of wavelengths of at least one of 730-770 nm, 850-890 nm, 880-920 nm, and 930-970 nm.

12. The method of claim 1, wherein applying the one or the combination of the selected light wavelengths begins prior to an initiation of a clinical intervention.

13. The method of claim 12, wherein the clinical intervention includes one of administering a clot-busting drug, inflating or deflating an angioplasty balloon, resuscitation, transfusion, and administering vaso-active drugs.

14. The method of claim 1, further comprising applying the one or the combination of the selected light wavelengths during the reoxygenation of the tissue.

15. The method of claim 1, further comprising applying the one or the combination of the selected light wavelengths after an initiation of a clinical intervention.

16. The method of claim 15, wherein the clinical intervention includes one of administering a clot-busting drug, inflating or deflating an angioplasty balloon, resuscitation, transfusion, and administering vaso-active drugs.

17. The method of claim 1, further comprising selectively reducing the amount of light being applied to the patient by the light source following the onset of reoxygenation of the tissue.

18. The method of claim 17, wherein the amount of light being applied to the patient is selectively reduced by selectively disabling the light source at different times.

19. The method of claim 17, wherein the amount of light being applied to the patient is selectively reduced by selectively disabling discrete groups of lights within the light source at different times.

20. The method of claim 17, wherein the amount of light being applied to the patient is selectively reduced by moving the light source further away from the patient.

21. The method of claim 1, wherein applying the one or the combination of the selected light wavelengths further comprises applying a light wavelength of approximately 930-970 nm.

22. A treatment method, comprising:

diagnosing a condition in a tissue of a patient that results in an ischemic event to occur in the tissue;

providing an amount of light from a light source having an array of output lights that include different light wavelengths between 700 nm and 1000 nm;

applying, based on the diagnosed condition, one or a combination of light wavelengths to the patient using the light source, during an onset of reperfusion; and

selectively reducing the amount of light being applied to the patient by the light source following an onset of reoxygenation of the tissue;

wherein applying the one or the combination of light wavelengths begins prior to the onset of reoxygenation of the tissue.

23. The method of claim 22, wherein:

diagnosing the condition comprises diagnosing a pathological condition that includes neonatal hypoxia; and

applying the one or the combination of light wavelengths comprises applying to a scalp of the patient using the light source.

24. The method of claim 23, wherein applying the one or the combination of light wavelengths further comprises applying the one or the combination of light wavelengths that includes one of approximately 750 nm and approximately 950 nm.

25. The method of claim 24, further comprising applying up to approximately 5 W/cm² of infrared light power.

26. The method of claim 22, wherein:

diagnosing the condition comprises diagnosing a pathological condition that includes multiple sclerosis; and

applying the one or the combination of light wavelengths comprises applying to one of the head and spinal cord.

27. The method of claim 26, wherein applying the one or the combination of light wavelengths further comprises applying the one or the combination of light wavelengths that includes one of approximately 870 nm and approximately 950 nm.

28. The method of claim 27, further comprising applying up to approximately 5 W/cm² of infrared power.

29. The method of claim 22, wherein:

diagnosing the condition comprises diagnosing a pathological condition that includes a spinal cord injury; and

applying the one or the combination of light wavelengths comprises applying to the spinal cord.

30. The method of claim 29, wherein applying the one or the combination of light wavelengths further comprises applying the one or the combination of light wavelengths that includes approximately 870 nm.

31. The method of claim 30, further comprising applying up to approximately 5 W/cm² of infrared power.

32. The method of claim 22, wherein the one or the combination of light wavelengths applied includes a wavelength falling in at least one of a range of approximately 730-770 nm, approximately 850-890 nm, approximately 880-920 nm, and approximately 930-970 nm.

33. The method of claim 22, wherein the amount of light being applied to the patient is selectively reduced by selectively disabling the light source at different times.

34. The method of claim 22, wherein the amount of light being applied to the patient is selectively reduced by selectively disabling discrete groups of lights within the light source at different times.

35. The method of claim 22, wherein the amount of light being applied to the patient is selectively reduced by moving the light source further away from the patient.

36. The method of claim 22, wherein applying the one or the combination of light wavelengths occurs during the onset of reoxygenation of the tissue.

37. The method of claim 22, wherein applying the one or the combination of light wavelengths further comprises applying a light wavelength of approximately 930-970 nm.

38. A light therapy method, comprising:

identifying a pathological condition in a patient that causes ischemia in a tissue of the patient;

selecting at least one light wavelength based on the identified pathological condition; and

applying one or a combination of the selected light wavelengths to the tissue of the patient using an amount of light from a light source;

wherein at least one of the selected light wavelengths falls in a range of 930-970 nm;

wherein applying the one or the combination of the selected light wavelengths begins prior to the onset of reoxygenation of the tissue; and

wherein applying the one or the combination of the selected light wavelengths occurs after an onset of reoxygenation of the tissue.

39. The method of claim 38, wherein applying the one or the combination of the selected light wavelengths begins prior to an initiation of a clinical intervention.

40. The method of claim 39, wherein the clinical intervention includes one of administering a clot-busting drug, inflating or deflating an angioplasty balloon, resuscitation, transfusion, and administering vaso-active drugs.

41. The method of claim 38, further comprising applying the one or the combination of the selected light wavelengths during reoxygenation of the tissue.

42. The method of claim 38, further comprising applying the one or the combination of the selected light wavelengths after an initiation of a clinical intervention.

43. The method of claim 42, wherein the clinical intervention includes one of administering a clot-busting drug, inflating or deflating an angioplasty balloon, resuscitation, transfusion, and administering vaso-active drugs.

44. The method of claim 38, further comprising selectively reducing the amount of light being applied to the patient by the light source following an onset of reoxygenation of the tissue.

45. The method of claim 44, wherein the amount of light being applied to the patient is selectively reduced by selectively disabling the light source at different times.

46. The method of claim 44, wherein the amount of light being applied to the patient is selectively reduced by selectively disabling discrete groups of lights within the light source at different times.

47. The method of claim 44, wherein the amount of light being applied to the patient is selectively reduced by moving the light source further away from the patient.

48. A method of treating an ischemic event in tissue of a subject in need thereof, the method comprising:

applying light to a tissue, prior to an onset of reperfusion, the light having wavelengths selected from two or more of the ranges selected from 730-770 nm, 850-890 nm, 880-920 nm, and 930-970 nm, thereby to reduce ischemic reperfusion injury in the tissue of the subject.

49. The method of claim 48, wherein the light applied comprises light having wavelengths in the range of 730-770 nm and 850-890 nm.

50. The method of claim 49, where in the light applied has wavelengths of about 750 nm and about 870 nm.

51. The method of claim 48, wherein the light applied comprises light having wavelengths in the range of 730-770 nm and 930-970 nm.

52. The method of claim 51, where in the light applied has wavelengths of about 750 nm and about 950 nm.

53. The method of claim 48, wherein the light applied does not comprise a wavelength of about 810 nm.

54. The method of claim 48, wherein the light applied has a power density in the range of 200 mW/cm² to 800 mW/cm².

55. The method of claim 48, wherein the light applied has a power density of approximately 200 mW/cm².

56. The method of claim 48, wherein the light applied is generated by one or more light emitting diodes.

57. The method of claim 56, wherein the light emitting diodes produce light having wavelengths of about 750 nm and about 870 nm.

58. The method of claim 56, wherein the light emitting diodes produce light having wavelengths of about 750 nm and about 950 nm.

59. The method of claim 48, wherein the tissue is brain tissue.

60. The method of claim 48, wherein the light is applied to the tissue for at least 2 hours after the onset of reperfusion.

61. A method of treating an ischemic event in tissue of a subject in need thereof, the method comprising:

applying light to a tissue, prior to an onset of reperfusion, thereby to reduce ischemic reperfusion injury in the tissue of the subject;

wherein the light applied is generated by one or more light emitting diodes; and

wherein the light emitting diodes produce light having wavelengths of;

about 750 nm and about 870 nm;

or

about 750 nm and about 950 nm.

62. The method of claim 61, wherein the light applied has a power density in the range of 200 mW/cm² to 800 mW/cm².

63. The method of claim 61, wherein the light applied has a power density of approximately 200 mW/cm².

64. The method of claim 61, wherein the tissue is brain tissue.

65. The method of claim 61, wherein the light is applied to the tissue for at least 2 hours after the onset of reperfusion.

66. The method of claim 61, wherein the light emitting diodes produce light having wavelengths of about 750 nm and about 870 nm.

67. The method of claim 61, wherein the light emitting diodes produce light having wavelengths of about 750 nm and about 950 nm.