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Lesion generation through bone using histotripsy therapy without aberration correction

  • US 10,071,266 B2
  • Filed: 09/03/2015
  • Issued: 09/11/2018
  • Est. Priority Date: 08/10/2011
  • Status: Active Grant
First Claim
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1. A method of treating tissue with ultrasound energy, comprising:

  • positioning a focus of an ultrasound transducer on a target tissue;

    delivering at least one ultrasound pulse from the ultrasound transducer though a bone aberrator, the at least one ultrasound pulse having a focal pressure above a cavitation initiation threshold of the target tissue;

    forming a cavitation bubble cloud on the focus with the at least one ultrasound pulse; and

    in the event that a secondary cavitation bubble cloud develops away from the focus due to the bone aberrator, decreasing a power level of the ultrasound transducer until the secondary bubble cloud disappears.

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