Lesion generation through bone using histotripsy therapy without aberration correction
First Claim
1. A method of treating tissue with ultrasound energy, comprising:
- positioning a focus of an ultrasound transducer on a target tissue;
delivering at least one ultrasound pulse from the ultrasound transducer though a bone aberrator, the at least one ultrasound pulse having a focal pressure above a cavitation initiation threshold of the target tissue;
forming a cavitation bubble cloud on the focus with the at least one ultrasound pulse; and
in the event that a secondary cavitation bubble cloud develops away from the focus due to the bone aberrator, decreasing a power level of the ultrasound transducer until the secondary bubble cloud disappears.
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Abstract
A medical imaging and therapy device is provided that may include any of a number of features. The device may include a Histotripsy transducer, a generator and controller configured to deliver Histotripsy energy from the transducer to target tissue, and an imaging system. In some embodiments, a method of treating tissue with Histotripsy energy comprises positioning a focus of a histotripsy transducer on a target tissue, delivering histotripsy energy from the histotripsy transducer through a bone aberrator, forming a histotripsy bubble cloud on the focus, and preventing the formation of secondary histotripsy bubble clouds without implementing an aberration correction algorithm.
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Citations
15 Claims
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1. A method of treating tissue with ultrasound energy, comprising:
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positioning a focus of an ultrasound transducer on a target tissue; delivering at least one ultrasound pulse from the ultrasound transducer though a bone aberrator, the at least one ultrasound pulse having a focal pressure above a cavitation initiation threshold of the target tissue; forming a cavitation bubble cloud on the focus with the at least one ultrasound pulse; and in the event that a secondary cavitation bubble cloud develops away from the focus due to the bone aberrator, decreasing a power level of the ultrasound transducer until the secondary bubble cloud disappears. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification